Course10410312140 lectures
Essentials Of Biomolecules : Nucleic Acids And Peptides
Prof. Lal Mohan Kundu · IIT Guwahati
Lectures
Week 1: Introduction, Nucleic acids and proteins
- Lec 1 : Importance of Biomolecules
- Lec 2 : DNA double helix: Chemical parameters
- Lec 3 : DNA and Proteins
Week 2 : Nucleic acids and proteins
- Lec 4: Amino acids and Proteins
- Lec 5: Protein 3D structures, folding and denaturation
- Lec 6: Chemical synthesis pyrimidine nucleobases
Week 3 : Synthesis of Nucleobases and Nucleotides
- Lec 7: Chemical synthesis purine nucleobases, Prebiotic chemistry
- Lec 8: Synthesis of nucleosides
- Lec 9: Solid phase DNA synthesis
Week 4 : DNA Replication, Polymerases, DNA Sequencing and PCR
- Lec 10: Chemistry and Biology of DNA Replication
- Lec 11: Chemistry of Polymerase Chain Reaction
- Lec 12: Major components and steps involved in Polymerase chain reaction
- Lec 13: DNA sequencing: Sanger's di-deoxy method
Week 5: DNA Replication, Polymerases, DNA Sequencing and PCR
Week 6: DNA damage, mutation and cancer
- Lec 17: Chemistry behind DNA damage and mutation
- Lec 18: Chemistry behind DNA damage and mutation
- Lec 19: DNA repair
DNA to proteins: transcription, translation and genetic code
- Transcription - The transfer of genetic information from DNA to mRNA
- Translation - The transfer of genetic information from mRNA to protein I
- Translation - The transfer of genetic information from mRNA to protein II
Week 8: Protein Sequencing and Solid Phase Peptide Synthesis (SPPS)
- Lec 23: Role of Ribosome in protein synthesis and the concept of codon
- Lec 24: Protein sequencing using Sanger's and Edman's degradation methods
- Lec 25: Mass spectroscopy and other sequencing methods for large proteins
Week 9: Chemical Synthesis of Peptides and its therapeutic applications; Spectroscopic techniques for biomolecules.
- Lecture 26: Solution phase peptide synthesis : mechanism and end protection
- Lecture 27: Peptide coupling agents, Solid phase synthesis, peptide based therapeutics
- Lecture 28: Spectroscopic techniques
Week 10: Modern techniques for biomolecules study, purification and characterization; Molecular probes
- Lecture 29: Spectrospic techniques -II and Purification technique-I of biomolecules
- Lecture 30: Purification techniques-II and Characteriation techniques of biomolecules
- Lecture 31: Molecular probes : PNA and LNA-I
Week 11: Molecular probes and Chemistry of carbohydrates
- Lecture 32: Molecular Probes: PNA and LNA - II
- Lecture 33: Carbohydrate chemistry-I: Introduction and Synthesis
Week 12: Chemistry of carbohydrates and Recap
- Lecture 34: Carbohydrate chemistry -II: Polysaccharides and its nanoparticles
- Lecture 35: Carbohydrate chemistry -III: Synthesis of nanoparticles; Recap of all modules.
Live Session
Syllabus and materials
At NPTEL, as the course publishes them.
Credits and licence
- Institution
- IIT Guwahati
- Department
- Chemistry and Biochemistry
- Teacher
- Prof. Lal Mohan Kundu
- Level
- Undergraduate
- Language
- English
- Subjects
- Chemistry
- Source
- NPTEL
- Licence
- CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
- Attribution
- NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
- Who can watch
- NPTEL gives no rating. Invisible Network shows it to Teens profiles and older, judged from what the source says about it. How courses are placed
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