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Essentials Of Biomolecules : Nucleic Acids And Peptides

Prof. Lal Mohan Kundu · IIT Guwahati

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Lectures

Week 1: Introduction, Nucleic acids and proteins

  1. Lec 1 : Importance of Biomolecules Video
  2. Lec 2 : DNA double helix: Chemical parameters Video
  3. Lec 3 : DNA and Proteins Video

Week 2 : Nucleic acids and proteins

  1. Lec 4: Amino acids and Proteins Video
  2. Lec 5: Protein 3D structures, folding and denaturation Video
  3. Lec 6: Chemical synthesis pyrimidine nucleobases Video

Week 3 : Synthesis of Nucleobases and Nucleotides

  1. Lec 7: Chemical synthesis purine nucleobases, Prebiotic chemistry Video
  2. Lec 8: Synthesis of nucleosides Video
  3. Lec 9: Solid phase DNA synthesis Video

Week 4 : DNA Replication, Polymerases, DNA Sequencing and PCR

  1. Lec 10: Chemistry and Biology of DNA Replication Video
  2. Lec 11: Chemistry of Polymerase Chain Reaction Video
  3. Lec 12: Major components and steps involved in Polymerase chain reaction Video
  4. Lec 13: DNA sequencing: Sanger's di-deoxy method Video

Week 5: DNA Replication, Polymerases, DNA Sequencing and PCR

  1. Lec 14: DNA sequencing: Maxam- Gilbert method Video
  2. Lec 15: Numerical Problem - 1 Video
  3. Lec 16: Sugar Chemistry Video

Week 6: DNA damage, mutation and cancer

  1. Lec 17: Chemistry behind DNA damage and mutation Video
  2. Lec 18: Chemistry behind DNA damage and mutation Video
  3. Lec 19: DNA repair Video

DNA to proteins: transcription, translation and genetic code

  1. Transcription - The transfer of genetic information from DNA to mRNA Video
  2. Translation - The transfer of genetic information from mRNA to protein I Video
  3. Translation - The transfer of genetic information from mRNA to protein II Video

Week 8: Protein Sequencing and Solid Phase Peptide Synthesis (SPPS)

  1. Lec 23: Role of Ribosome in protein synthesis and the concept of codon Video
  2. Lec 24: Protein sequencing using Sanger's and Edman's degradation methods Video
  3. Lec 25: Mass spectroscopy and other sequencing methods for large proteins Video

Week 9: Chemical Synthesis of Peptides and its therapeutic applications; Spectroscopic techniques for biomolecules.

  1. Lecture 26: Solution phase peptide synthesis : mechanism and end protection Video
  2. Lecture 27: Peptide coupling agents, Solid phase synthesis, peptide based therapeutics Video
  3. Lecture 28: Spectroscopic techniques Video

Week 10: Modern techniques for biomolecules study, purification and characterization; Molecular probes

  1. Lecture 29: Spectrospic techniques -II and Purification technique-I of biomolecules Video
  2. Lecture 30: Purification techniques-II and Characteriation techniques of biomolecules Video
  3. Lecture 31: Molecular probes : PNA and LNA-I Video

Week 11: Molecular probes and Chemistry of carbohydrates

  1. Lecture 32: Molecular Probes: PNA and LNA - II Video
  2. Lecture 33: Carbohydrate chemistry-I: Introduction and Synthesis Video

Week 12: Chemistry of carbohydrates and Recap

  1. Lecture 34: Carbohydrate chemistry -II: Polysaccharides and its nanoparticles Video
  2. Lecture 35: Carbohydrate chemistry -III: Synthesis of nanoparticles; Recap of all modules. Video

Live Session

  1. Live Session 15-02-2021 Video
  2. Live Session 02-03-2021 Video
  3. Live Session 05-04-2021 Video
  4. Live Session 24-02-2020 Video
  5. Live Session 03-04-2022 Video

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IIT Guwahati
Department
Chemistry and Biochemistry
Teacher
Prof. Lal Mohan Kundu
Level
Undergraduate
Language
English
Subjects
Chemistry
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
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