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Principles of Organic Synthesis

Prof. T Punniyamurthy · IIT Guwahati

Start with lecture 1 At NPTEL

About

The course has nine modules starting from the formation of acid-catalyzed carbon-carbon bond formation to application of the modern transition metal catalysis. Students of graduate and post graduate preparing for NET and GATE examination will find this course extremely useful.

INTENDED AUDIENCE : M.Sc Students/faculty

PREREQUISITES : BSc (Chemistry)

INDUSTRY SUPPORT : Dr. Reddy’s Laboratory, Syngenta, etc

Lectures

Week 1: Formation of Aliphatic Carbon-Carbon Bonds: Base Catalyzed Reactions

  1. Lec 1: Aldol Reaction YouTube
  2. Lec 2: Perkin, Claisen and Thorpe Reactions YouTube

Week 2: Formation of Aliphatic Carbon-Carbon Bonds: Base/Acid Catalyzed Reactions

  1. Lec 1: Reaction of Enolates YouTube
  2. Lec 2: Reaction of alkenes and carbonyl compounds YouTube

Week 3: Formation of Aliphatic Carbon-Carbon Bonds: Acid Catalyzed Reactions

  1. Lec 1: Mannich reaction YouTube
  2. Lec 2: Friedel-Crafts and Prins Reactions YouTube

Week 4: Organometallic Reagents

  1. Lec 1: Grignard Reagents YouTube
  2. Lec 2: Organolithium Reagents YouTube

Week 5: Organometallic Reagents/ Formation of Aliphatic Carbon-Nitrogen Bonds

  1. Lec 1: Organocopper, Organozinc and Organomercury Reagents YouTube
  2. Lec 2: Ritter Reaction and Gabriel Synthesis YouTube

Week 6: Formation of Aliphatic Carbon-Nitrogen Bonds

  1. Lec 1: Reactions of imines and enamines, synthesis of alkaloids and amino acids YouTube
  2. Lec 2: Reactions of electrophilic and nucleophilic nitrogens, synthesis of amino acids and peptides YouTube

Week 7: Electrophilic Aromatic Substitution

  1. Lec 1: Priciples, effect of substituents and carbon-carbon bond formation YouTube
  2. Lec 2: Formylation/acylation and related reactions YouTube

Week 8: Electrophilic and Nucleophilic Aromatic Substitution

  1. Lec 1: Nitration, Sulfonation and other reactions YouTube
  2. Lec 2: Principle, Substitution mechanism and reactions of Benzyne YouTube

Week 9: Nucleophilic Aromatic Substitution

  1. Lec 1: Schiemann Reaction, Ullmann reaction and Stephens-Castro coupling YouTube
  2. Lec 2: Ziegler Alkylation, Chichibabin Reaction, Von Richter Rearrangement, Smiles Rearrangement, Bamberger Rearrangement and Bucherer Reaction YouTube

Week 10: Aromatic Diazonium Salts

  1. Lec 1: Preparation, properties and reactions YouTube
  2. Lec 2: Coupling reactions, Japp-Klingemann reaction and Tiffeneau-Demjanov rearrangement YouTube

Week 11: Aromatic Diazonium Salts, Molecular Rearrangements and Reagents Containing Phosphorus

  1. Lec 1: Applications of diazonium salts YouTube
  2. Lec 2: Wagner-Meerwein rearrangment, Pinacol rearrangment, Benzilic acid rearrangment and Arndt-Eistert synthesis YouTube
  3. Lec 3: Rearrangement of halogen, oxygen, sulfur and nitrogen containing centre YouTube
  4. Lec 4: Rearrangement to electron-Rich carbon YouTube
  5. Lec 5: Reactivity and several reactions YouTube

Week 12: Reagents Containing Sulfur, Silicon, Boron, Tin and Free-Radical Reactions

  1. Lec 1: Reactions of sulfur and silicon containing reagents YouTube
  2. Lec 2: Preparation and reactions of organoborane and organotin reagents YouTube
  3. Lec 3: Formation of carbon-carbon and carbon-halogen bonds YouTube
  4. Lec 4: Cu, Mn, Sm, and Sn Based Reactions, Acyloin Condensation YouTube
  5. Lec 5: C-N, C-O bond formation and decarboxylation YouTube

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IIT Guwahati
Department
Chemistry and Biochemistry
Teacher
Prof. T Punniyamurthy
Level
Graduate
Language
English
Subjects
Chemistry
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
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