Diagnosing Beryllium Sensitization and Chronic Beryllium Disease in Beryllium Exposed Workers

About

Workers occupationally exposed to beryllium are at risk of developing beryllium sensitization (BeS) and chronic beryllium disease (CBD). Risk of developing disease is related to both exposure and genetics. Some workforces use the beryllium lymphocyte proliferation test (BeLPT) as part of medical surveillance. BeLPT testing identifies workers with abnormal BeLPT's and recommends additional clinical testing to ascertain whether an individual has developed lung pathology consistent with CBD. These individuals are at risk of developing symptoms affecting quality of life and require regular follow-up and collaboration between their local primary care providers and pulmonary specialists.

This presentation will review the tests utilized in a diagnostic clinical evaluation and the findings consistent with beryllium sensitization (BeS) and chronic beryllium disease (CBD). These include: • Detailed history and physical, with focus on occupational exposures • Pulmonary function tests • Radiography (chest x-ray with B read, or chest CT) • Lung lavage and transbronchial lung biopsy • Cardiopulmonary exercise testing • BeLPT of lavage fluid

Dr. Maier will discuss recommendations for both PPE, and/or removal from further occupational exposure. Recommendations for follow-up of individuals with both BeS and CBD will be provided. Treatment options for workers who have progressed to symptomatic disease will be outlined.

00:00:00 Slide 1

00:00:32 Slide 2

00:00:46 Slide 3

00:02:17 Slide 4

00:05:57 Slide 5

00:06:59 Slide 6

00:07:58 Slide 7

00:08:59 Slide 8

00:09:51 Slide 9