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Normal Blood Cells

Clinical Hematology Atlas: A Pictorial Guide for the Hematology Laboratory · LibreTexts

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    From LibreTexts, under CC BY-NC-SA 4.0, as the source states it; its equations are written in TeX, which the PDF shows typeset. This page at LibreTexts.

    1. Polymorphonuclear Segmented Neutrophil (PMN)
    2. Band Neutrophil
    3. Eosinophil
    4. Basophil
    5. Monocyte
    6. Lymphocyte
    7. Reactive Lymphocyte
    8. Plasmacytoid Lymphocyte
    9. Red Blood Cell
    10. Platelet

    Normal Cells.png

    Polymorphonuclear Segmented Neutrophil (PMN)

    • Cell size:  10-16 microns
    • N/C ratio 1:1
    • 2-5 distinct nuclear lobes (filament connecting lobes)
    • Central or eccentric nucleus
    • Deep blue-purple coarsely granular nuclear chromatin (distinct parachromatin)
    • No nucleoli
    • Abundant pink cytoplasm
    • Fine violet-pink specific granules

    PMN \(\PageIndex{}\)

     

    Band Neutrophil

    • Cell size:  10-16 microns
    • N/C ratio 1:1
    • Elongated narrow band shape of uniform thickness, singular lobe
    • Central or eccentric nucleus
    • Deep blue-purple coarsely granular nuclear chromatin (distinct parachromatin)
    • No nucleoli
    • Abundant pink cytoplasm
    • Fine violet-pink specific granules

    Band \(\PageIndex{}\)

     

    Eosinophil

    • Cell size:  10-16 microns
    • N/C ratio 1:1
    • 2 distinct nuclear lobes - rarely 3 or 4 (filament connecting)
    • Central or eccentric nucleus
    • Deep blue-purple coarsely granular nuclear chromatin
    • No nucleoli
    • Abundant pink cytoplasm
    • Large red, uniform specific granules

    Eosinophil \(\PageIndex{}\)

     

    Basophil

    • Cell size:  10-16 microns
    • N/C ratio 1:1
    • 2 distinct nuclear lobes - rarely 3 or 4 (filament connecting)
    • Central or eccentric nucleus
    • Deep blue-purple coarsely granular nuclear chromatin
    • No nucleoli
    • Abundant pale blue cytoplasm
    • Coarse purple-black non-uniform specific granules (water soluble - may dissolve in staining)

    Basophil \(\PageIndex{}\)

    Basophils and immature granulocytes- compare to promyelocytes

     

    Monocyte

    • Cell size:  12-20 microns
    • N/C ratio 2:1 or 1:1
    • Cerebriform or horseshoe shaped nucleus
    • Central nucleus
    • Blue-purple, fine reticular nuclear chromatin (less distinct parachromatin)
    • 0-2 Nucleoli
    • Abundant pale gray-blue cytoplasm. May see pseudopodia and vacuoles
    • Numerous very fine (dust like) red granules evenly dispersed

    Monocyte \(\PageIndex{}\)

     

     

    Lymphocyte

    • Cell size:  7-18 microns (usually 9-12)
    • N/C ratio 4:1 (occasionally 3:1)
    • Round or indented nucleus
    • Eccentric nucleus often with scanty cytoplasm
    • Homogeneous, coarse blue-purple nuclear chromatin (smudged)
    • Nucleoli often absent but may see in mature forms
    • Light to dark blue cytoplasm, scanty to moderate
    • Occasionally a few azurophilic granules seen

    Small Lymph \(\PageIndex{}\)

    Average  to Large Lymph \(\PageIndex{}\)

     

    Reactive Lymphocyte

    • Activated T-Lymph
    • Wandering or Ballerina skirt cytoplasm often indented by adjacent red blood cells
    • Bluer cytoplasm periphery especially where indented by red blood cells
    • Nucleus also has wandering appearance
    • Coarser nuclear chromatin

    Reactive Lymph \(\PageIndex{}\)

     

    Plasmacytoid Lymphocyte

    • Activated B- Lymph
    • Generally considered a lymph transitioning to a plasma cell
    • Slightly larger with darker royal blue cytoplasm and more heavily clumped chromatin
    • May lack very eccentric nucleus and well developed golgi of plasma cell

    Plasmacytoid Lymph \(\PageIndex{}\)

     

    Red Blood Cell

    • Cell size: 6-8 microns
    • Clear pink to red cytoplasm, central pallor 1/3 of cell diameter
    • No cytoplasmic granules

    RBC\(\PageIndex{}\)

     

    Platelet

    • Cell size:  2-4 microns
    • Light blue, fragment of megakaryocyte cytoplasm
    • Evenly dispersed, fine red-purple granules

    Platelet \(\PageIndex{}\)

     

     

     

     

    This page titled Normal Blood Cells was last modified on Tue, 12 Sep 2023 19:31:04 GMT and is shared under a CC BY-NC-SA 4.0 license and was authored, remixed, and/or curated by Caroline Doty and Dawn Taylor.