21.6: Synthesis of Amines by Reductive Amination

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    Reductive Amination

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    Aldehydes and ketones can be converted into 1o, 2o and 3o amines using reductive amination. The reaction takes place in two parts. The first step is the nucleophiic addition of the carbonyl group to form an imine. The second step is the reduction of the imine to an amine using an reducing agent. A reducing agent commonly used for this reaction is sodium cyanoborohydride (NaBH3CN).

    21.6: Synthesis of Amines by Reductive Amination is shared under a CC BY-NC-SA 4.0 license and was authored, remixed, and/or curated by LibreTexts.