Opening the book…
Figure 8.1.1: Steps of Fertilization
This image illustrates fertilization in three labeled steps, showing how sperm cells reach and penetrate the oocyte and how one sperm ultimately fuses with the oocyte.
Step 1
Hundreds of sperm attracted to the corona radiata begin to break through the barrier of granulosa cells and approach the zona pellucida.
Multiple sperm surround the oocyte and move through the corona radiata, the outer layer of granulosa cells surrounding the egg. The sperm are shown approaching the zona pellucida, a protective glycoprotein layer surrounding the oocyte.
Step 2
Contact with the zona pellucida triggers the acrosome reaction, causing sperm to secrete digestive enzymes that break down the glycoprotein membrane of the zona pellucida and help expose the oocyte's plasma membrane.
As sperm contact the zona pellucida, enzymes are released from the acrosome at the tip of the sperm head. These enzymes digest portions of the zona pellucida, creating pathways that allow sperm to move closer to the oocyte's plasma membrane.
Step 3
A single sperm succeeds in burrowing through the corona radiata and zona pellucida and making contact with the oocyte's plasma membrane. The sperm's plasma membrane fuses with that of the oocyte, and the sperm releases its nucleus into the cytoplasm of the oocyte.
An enlarged view shows several sperm approaching the oocyte through the corona radiata and across the zona pellucida. Each sperm contains an acrosome at the tip of its head and a sperm nucleus within the head region. The plasma membrane surrounds the oocyte, and sperm receptors in the plasma membrane are shown at the site where sperm binding occurs. One sperm successfully penetrates the corona radiata and zona pellucida and reaches the plasma membrane. Fusion of the sperm and oocyte plasma membranes allows the sperm nucleus to enter the oocyte cytoplasm. Additional sperm remain outside the zona pellucida and do not enter the oocyte.
The figure demonstrates the sequence of events during fertilization. Sperm first move through the corona radiata, then undergo the acrosome reaction to penetrate the zona pellucida. After one sperm binds to and fuses with the oocyte plasma membrane, its nucleus enters the oocyte cytoplasm, initiating the process that leads to formation of a zygote. The corona radiata, zona pellucida, plasma membrane, and sperm receptors function together to regulate sperm access and help ensure that only one sperm fertilizes the oocyte.
Figure 8.1.2: In Vitro Fertilization (IVF)
This image illustrates in vitro fertilization (IVF) labeled steps 1a, 1b, 2, 3, and 4.
Step 1a: “Eggs are collected after ovulation or directly from the follicles. Sperm are collected and concentrated.” The image shows an Egg (oocyte) being removed using a Catheter.
Step 1b: “Sperm sample is collected and concentrated by removing seminal fluid.” Two test tubes are shown, with an arrow indicating concentration of the sperm sample.
Step 2: “Both the collected egg(s) and the sperm sample are mixed in a petri dish, allowing fertilization to occur.” A petri dish shows sperm surrounding an oocyte.
Step 3: “The fertilized zygote is then removed from the petri dish for implantation.” A catheter removes the Fertilized zygote from the dish.
Step 4: “The zygote is then surgically implanted into the endometrium of the uterus. After successful implantation, the zygote should develop normally, as if it had been fertilized in the female’s oviducts.” The image labels Implanted zygote and Endometrium inside the uterus.
Arrows indicate progression between steps from collection to implantation
Figure 8.2.1: Stages of Early Embryonic Development
This image shows stages of early embryonic development and where they occur.
The top row, labeled as occurring in the uterine tube (red background), shows three stages: Two-cell, Four-cell, and Eight-cell, each illustrating increasing numbers of cells within the same overall size.
The bottom row, labeled as occurring in the uterus (blue background), shows later stages: Morula (16 cells), appearing as a solid ball of cells, and Blastocyst (70–100 cells), which contains a fluid-filled cavity labeled Blastocoel. The blastocyst also includes an outer layer labeled Trophoblast and a cluster of cells labeled Inner cell mass.
A legend indicates red corresponds to “Occurs in uterine tube” and blue corresponds to “Occurs in uterus.”
As the blastocyst forms, the trophoblast excretes enzymes that begin to degrade the zona pellucida. In a process called “hatching,” the conceptus breaks free of the zona pellucida in preparation for implantation.
Figure 8.2.2: The Sequence of Early Human Development
This image shows the sequence of early human development from ovulation through implantation, with numbered stages 1 through 8 arranged along the uterine tube and into the uterus.
- Stage 1: “Unfertilized Oocyte” shows an oocyte before fertilization.
- Stage 2: “Fertilized Oocyte” shows sperm surrounding and penetrating the oocyte.
- Stage 3: “Two-cell stage” shows the zygote divided into two blastomeres.
- Stage 4: “Four-cell stage” shows four cells within the same outer boundary.
- Stage 5: Two panels show progression to the Eight-cell stage and then Morula (16 cells), a solid ball of cells.
- Stage 6: “Blastocyst (70–100 cells)” shows a structure with a fluid-filled cavity labeled Blastocoel, an outer layer labeled Trophoblast, and a cluster labeled Inner cell mass. Arrows trace movement along the uterine tube toward the uterus, indicating progression of development during transport.
- Stage 7: “Embryo hatches (sheds zona pellucida)” shows the blastocyst emerging from its outer covering.
- Stage 8: “Blastocyst rotates and implants into endometrium of the uterus” shows attachment to the uterine lining.
Figure 8.2.3: Steps of Blastocyst Implantation
This image illustrates the process of implantation of the blastocyst into the uterine lining in three labeled steps.
At the top, the uterine wall is labeled with Endometrium and Uterine cavity, and individual cells are labeled Uterine mucosa cells.
- Step 1: “The blastocyst digests the uterine mucosa when it initially implants into the endometrium.” The blastocyst is shown attaching to and beginning to embed into the uterine lining. An arrow indicates progression downward.
- Step 2: “Eventually, the endometrium grows over and surrounds the embryo, fully securing it to the uterine lining.” The blastocyst is shown more deeply embedded, with surrounding endometrial tissue enclosing it. Another arrow indicates further progression.
- Step 3: “Implanted embryo continues to grow within endometrium (depicted embryo is 7–8 weeks after conception).” A cross-section of the uterus shows the developing embryo within the uterine wall.
To the right, additional diagrams labeled Anterior view and Lateral view indicate the most common site of implantation (posterior uterine wall). The figure emphasizes the sequence of implantation and the typical location within the uterus.
Figure 8.2.4: Normal Placental Position and Placenta Previa
This image is a side‑by‑side diagram that compares the normal location of the placenta with a condition called placenta previa.
On the left, labeled “Normal location of placenta,” a cross‑section of the uterus shows the fetus positioned inside the uterine cavity. The placenta is attached to the upper uterine wall, away from the cervix. A label indicates that the cervix is not obstructed, allowing a clear passage for birth.
On the right, labeled “Placenta previa,” a similar cross‑section shows the placenta attached lower in the uterus. A label identifies the internal os, the opening of the cervix. The placenta is covering the cervix, which obstructs the passage and would prevent normal vaginal delivery.
The diagram emphasizes the difference between a normal placental position and one that blocks the cervical opening.
Figure 8.2.5: Implanted Blastocyst and Early Embryonic Layers
This image shows the structure of an implanted blastocyst within the uterine lining and the formation of early embryonic layers.
On the right side, the uterine wall is labeled Endometrium, shown as a layered tissue with blood vessels. The implanted structure is embedded within this lining. Within the implanted blastocyst, a central space is labeled Blastocyst cavity (develops into the yolk sac). Adjacent to this cavity is the embryonic disc, which consists of two labeled layers:
- Hypoblast (lower layer)
- Epiblast (upper layer)
Above the embryonic disc is a small space labeled Amniotic cavity, enclosed by a membrane labeled Amnion. Surrounding the blastocyst is the trophoblast, which is divided into two labeled layers:
- Cytotrophoblast, the inner cellular layer
- Syncytiotrophoblast, the outer invasive layer that extends into the endometrium
The diagram emphasizes the organization of embryonic tissues and supporting membranes after implantation and their relationship to the uterine lining.
Figure 8.2.6: Early Post-Implantation Development and Germ Layer Formation
This image illustrates early post-implantation development and the formation of the three primary embryonic germ layers.
Early Post-Implantation Embryo
The upper panel shows an implanted blastocyst embedded within the uterine lining. The uterine lining has reestablished itself over the implantation site, enclosing the developing embryo within the endometrium. The outer layer of the implanted conceptus is the trophoblast, which contributes to the formation of extraembryonic structures and supports implantation.
Inside the conceptus is a two-layered embryonic disc known as the bilaminar embryonic disc. The upper layer is the epiblast, and the lower layer is the hypoblast. A fluid-filled space above the epiblast forms the amniotic cavity, which will eventually surround and protect the developing embryo.
An arrow between the panels indicates progression to a later stage of development.
Formation of the Germ Layers
The lower panel shows a later stage in which the embryonic disc has been reorganized into three primary germ layers:
- Ectoderm, the outer layer
- Mesoderm, the middle layer
- Endoderm, the inner layer
The amniotic cavity remains above the embryo, while the trophoblast and surrounding endometrium continue to enclose the developing conceptus.
A magnified view focuses on the primitive streak, a temporary structure that appears along the surface of the epiblast. Cells migrate inward through the primitive streak during a process called gastrulation. Some migrating cells replace most of the hypoblast cells and form the endoderm. Other migrating cells spread between the developing ectoderm and endoderm to form the mesoderm. Cells that remain in the epiblast become the ectoderm.
A second inset identifies the level of the cross section used to illustrate these developmental changes.
The figure demonstrates the transition from a bilaminar embryonic disc to a trilaminar embryonic disc during gastrulation. Initially, the embryo consists of the epiblast and hypoblast. As cells migrate through the primitive streak, three germ layers are established: ectoderm, mesoderm, and endoderm. These germ layers provide the foundation for all tissues and organs of the developing body. The ectoderm gives rise primarily to the nervous system and skin, the mesoderm forms muscles, connective tissues, and the cardiovascular system, and the endoderm forms the lining of many internal organs and glands.
Figure 8.2.7: Early Embryo, Extraembryonic Membranes, and Germ Layer Derivatives
This image illustrates an early embryo within the uterus and shows how the three primary germ layers and extraembryonic membranes contribute to embryonic development.
The embryo is surrounded by several protective and supportive structures. The outermost membrane is the chorion, which lies within the endometrium, the lining of the uterus. Spaces within the surrounding tissue contain maternal blood pools, which bring nutrients and oxygen close to the developing embryo.
Within the chorion is the amniotic cavity, a fluid-filled space surrounding the embryo. The cavity is enclosed by the amnion, a membrane that protects the embryo and provides a stable environment for growth. Inferior to the embryo is the yolk sac, which is lined with endoderm and contributes to early nutrient transfer and blood cell formation. Extending from the embryo is the allantois, an embryonic structure involved in the development of the umbilical cord and early circulatory connections.
The embryo itself contains three primary germ layers formed during gastrulation:
- Ectoderm, the outer layer
- Mesoderm, the middle layer
- Endoderm, the inner layer
The figure emphasizes that these germ layers give rise to different tissues and organ systems.
- Endoderm develops into much of the digestive tract and associated organs, including the liver and pancreas, as well as the inner lining of the lungs.
- Mesoderm forms structures involved in support, movement, and transport, including the circulatory system, skeletal system, muscular system, and portions of the lungs.
- Ectoderm develops into external coverings and the nervous system, producing structures such as the skin, hair, nails, and the nervous system.
The figure demonstrates how the early embryo is supported by extraembryonic membranes while simultaneously undergoing differentiation into three germ layers. These germ layers serve as the foundation for all tissues and organs of the body. The chorion, amnion, yolk sac, and allantois support growth and survival of the embryo, while the ectoderm, mesoderm, and endoderm establish the developmental pathways that lead to the formation of the body's organ systems.
Figure 8.2.8: Placenta and Maternal-Fetal Exchange
This image illustrates the relationship between the developing fetus, the placenta, and the maternal blood supply. It shows how nutrients, gases, and wastes are exchanged between the fetus and the mother during pregnancy.
Fetus and Extraembryonic Membranes
The left panel shows a fetus developing within the uterus. The fetus is suspended in amniotic fluid contained within the amniotic cavity, which is enclosed by the amnion. The amniotic fluid cushions and protects the fetus while allowing movement during development.
Surrounding the amnion is the chorion, the outer fetal membrane. The chorion contributes to the formation of the placenta and serves as the fetal component of the maternal-fetal interface. A small yolk sac is present near the fetus and represents an early extraembryonic structure involved in nutrient transfer and blood cell formation during early development.
The fetus is connected to the placenta by the umbilical cord, which contains blood vessels that carry blood between the fetus and the placenta.
The placenta is attached to the wall of the uterus and serves as the primary site of exchange between the maternal and fetal circulatory systems.
Placental Exchange
The right panel enlarges the region where the placenta attaches to the uterine wall.
The fetal portion of the placenta contains branching structures called chorionic villi, which extend outward from the chorion into spaces filled with maternal blood. Within the chorionic villi are fetal blood vessels connected to the umbilical arteries and umbilical vein of the umbilical cord.
The maternal portion of the placenta is supplied by the uterine artery and uterine vein. Blood from the mother enters the intervillous space, where it surrounds the chorionic villi. Although maternal blood closely bathes the villi, it remains separated from fetal blood by placental tissues.
The umbilical arteries carry fetal blood from the fetus to the placental villi, where exchange occurs. Oxygen and nutrients move from the maternal blood in the intervillous spaces into the fetal circulation, while carbon dioxide and metabolic wastes move from fetal blood into the maternal circulation. The umbilical vein then carries oxygenated, nutrient-rich blood back to the fetus.
The figure demonstrates how the placenta functions as the interface between the maternal and fetal circulatory systems. The fetus develops within the protective environment of the amnion and amniotic fluid and remains connected to the placenta through the umbilical cord. The chorionic villi greatly increase the surface area available for exchange by extending into maternal blood-filled intervillous spaces. This arrangement allows efficient transfer of oxygen, nutrients, and waste products while keeping maternal and fetal blood supplies physically separate. The placenta therefore serves as the primary organ of exchange that supports fetal growth and development throughout pregnancy.
Figure 8.2.9: Human Placenta
This image shows a post‑expulsion human placenta placed in a shallow medical tray. The tray is light blue with visible fluid and blood staining around the placenta.
The placenta appears as a round, flattened organ with a smooth, slightly shiny surface. Numerous branching blood vessels are visible across its surface, radiating outward from a central point.
An umbilical cord is attached near the top of the placenta. The cord is thick, pale, and slightly twisted, extending outward from the placental surface.
A gloved hand is visible at the top left of the image, with one finger pointing toward the placental surface and the attachment site of the umbilical cord.
The image emphasizes the physical structure of the placenta, including its vascular network and umbilical cord connection.
Figure 8.2.10: Neurulation: Formation of the Neural Tube and Neural Crest
This figure illustrates neurulation, the process by which the neural tube forms from the embryonic ectoderm. The figure is presented as a sequence of four developmental stages shown in cross section.
Step 1: Neuroectodermal tissues differentiate from the ectoderm and thicken into the neural plate. The neural plate border separates the ectoderm from the neural plate.
The diagram labels:
- Neural plate border
- Neural plate
- Ectoderm
- Mesoderm
- Notochord
Step 2: The neural plate bends dorsally, with the two ends eventually joining at the neural plate borders, which are now referred to as the neural crest.
The diagram labels:
- Convergence
- Neural crest
Step 3: The closure of the neural tube disconnects the neural crest from the epidermis. Neural crest cells differentiate to form most of the peripheral nervous system.
The diagram labels:
- Ectoderm
- Neural crest cells (form components of the PNS)
- Neural tube
Step 4: The notochord degenerates and only persists as the nucleus pulposus of the intervertebral discs. Other mesoderm cells differentiate into the somites, the precursors of the axial skeleton and skeletal muscle.
The diagram labels:
- Epidermis
- Neural tube
- Spinal ganglion
- Somites (mesoderm-derived)
- Notochord (mesoderm-derived)
The figure shows the progression from neural plate formation through neural tube closure and subsequent differentiation of surrounding embryonic tissues. The neural tube becomes positioned beneath the epidermis, neural crest cells give rise to components of the peripheral nervous system, and mesoderm-derived tissues form the somites and notochord-derived structures.
This revision includes all numbered instructional steps and image labels while avoiding information that does not appear in the figure.
Figure 8.2.11: Embryonic Folding
This image is a multi‑panel diagram illustrates embryonic folding and the formation of the primitive gut from different germ layers. A color legend identifies Ectoderm (blue), Mesoderm (red), Endoderm (yellow), Amnion (green), and Hypoblast (purple).
Left column (transverse sections): The top image shows a flat embryonic disc with layers arranged from top to bottom: amnion, ectoderm, and hypoblast.
In the next transverse section, the embryo begins to fold inward. The outer layer labeled Ectoderm curves around the forming body, while Mesoderm lies beneath it, and Endoderm lines the inner surface. The Amnion surrounds the upper portion.
In the third transverse section, folding progresses further. The lateral edges move toward the midline, enclosing internal structures. The Endoderm begins forming a tube-like structure.
Arrows indicate the continuation of folding into the panels on the right.
Right column: sagittal and transverse views:
The top right image, labeled Sagittal section, shows longitudinal folding. The embryo curves, bringing the yolk sac closer to the body as folding occurs.
The next image, labeled Transverse section, shows the yolk sac narrowing and being incorporated into the embryo.
In the final transverse section, a structure labeled Gut is formed from the endoderm and enclosed within the body. The surrounding layers include Mesoderm, which forms the middle tissues, and Ectoderm, which forms the outer surface.
Figure 8.2.12: Embryo at 7 Weeks
This figure shows an early human embryo within surrounding embryonic membranes.
The embryo appears highly curved in a C‑shape, with a prominent head region and a tapering tail-like structure. Small limb buds are visible, indicating early development of arms and legs. A circular structure near the head represents the developing eye.
The embryo lies within a semi‑transparent environment of surrounding tissues and fluids. Thin, translucent membranes and vascular structures are visible around it, suggesting the embryonic support structures.
The overall coloration ranges from pale beige for the embryo to reddish and translucent tones in the surrounding tissues. The image emphasizes early organ formation and the curved body shape typical of early embryonic development.
Figure 8.3.1: Differentiation of the Embryonic Reproductive Ducts
This image illustrates the differentiation of the reproductive ducts from a common embryonic stage into male and female systems.
Top panel: An early embryo is shown with paired structures labeled Müllerian ducts (upper, red) and Wolffian ducts (lower, blue). On each side are Bipotential gonads, indicating that the gonads can develop into either testes or ovaries. At the bottom, a common outlet is labeled Cloaca.
Two labeled pathways extend downward: Masculinization on the left and Feminization on the right.
Left pathway (Masculinization): The label states Müllerian ducts degrade, shown as dashed outlines fading. The Wolffian ducts remain and develop further.
In the final male stage, the diagram shows Wolffian ducts become epididymis and ductus (vas) deferens, with structures labeled Testes, Urinary bladder, and Urethra.
Right pathway (Feminization): The label shows Wolffian ducts degrade, indicated by dashed outlines. The Müllerian ducts remain and develop into female reproductive structures.
In the final female stage, the diagram shows Müllerian ducts become uterine tubes and uterus, with structures labeled Ovaries, Urinary bladder, Urethra, Uterus, and Vagina.
Figure 8.3.2: Fetal Circulation and Major Fetal Shunts
This image is a multi-panel diagram illustrates fetal circulation, showing blood flow between the placenta, umbilical cord, and fetal heart.
Left panel: The Placenta is shown with branching blood vessels. A structure labeled Umbilical cord (contains umbilical artery and umbilical vein) connects the placenta to the fetus. Within the cord, the Umbilical vein carries oxygenated blood toward the fetus, while the Umbilical artery carries deoxygenated blood back to the placenta.
Bottom right panel (liver region): Blood labeled “1 Blood arrives via umbilical vein” enters the fetus. The label “2 The ductus venosus shunts oxygenated blood from the placenta away from the semi functional liver and toward the heart” shows blood bypassing much of the liver through the ductus venosus and entering the inferior vena cava.
Top right panel (heart): The fetal heart diagram includes numbered steps:
- “Oxygenated blood from placenta enters right atrium via inferior vena cava.”
- “The foramen ovale allows oxygenated blood in the right atrium to reach the left atrium.”
- “The ductus arteriosus connects the aorta with the pulmonary artery, further shunting blood away from the lungs and into the aorta.”
- “Mixed blood travels to the head and body, and back to the placenta via the aorta.”
Arrows (red, blue, and purple) show directions of blood flow and mixing. The diagram emphasizes three key fetal shunts:
- Ductus venosus (liver bypass)
- Foramen ovale (right atrium to left atrium)
- Ductus arteriosus (pulmonary artery to aorta)
Figure 8.4.1: Fetal Growth Across the Three Trimesters
This image shows the relative size and position of the fetus within the uterus across the three trimesters of pregnancy, overlaid on an outline of the human torso.
In the center, a simplified cross‑section of the lower abdomen shows the uterus with a fetus inside, connected to the fallopian tubes and ovaries on either side.
Three horizontal labels appear on the left side:
- “End of 1st trimester” points to the lower pelvis region. At this stage, the fetus is small and located within the pelvis, with minimal upward expansion of the uterus.
- “End of 2nd trimester” points to the middle abdomen. The uterus has expanded upward, occupying more space in the abdominal cavity as the fetus grows larger.
- “End of 3rd trimester” points to the upper abdomen near the ribcage. The uterus is greatly enlarged, extending high into the abdomen and approaching the chest area.
Behind the labels, shaded overlapping regions illustrate increasing uterine size, progressing from small (first trimester) to very large (third trimester). The diagram emphasizes how the uterus and fetus grow upward and expand significantly in size throughout pregnancy.
Figure 8.4.3: Hormones Initiating Labor
This image shows changes in relative hormone concentration over the course of pregnancy, measured from 0 to 40 weeks on the horizontal axis. Three hormones are represented:
- Human chorionic gonadotropin (hCG) is shown as a solid green line. It rises rapidly during early pregnancy, reaching a peak around weeks 8 to 10. After this peak, hCG levels decline sharply and then level off at a lower, steady concentration for the remainder of pregnancy.
- Progesterone is shown as a dashed blue line. Progesterone levels increase gradually throughout pregnancy, with a more pronounced rise after approximately week 20. The levels peak near the end of pregnancy and then slightly decrease.
- Estrogens are shown as a solid orange line. Estrogen levels begin low, increase slowly in early pregnancy, then rise steeply after about week 20. Estrogen concentrations continue increasing and reach their highest levels near week 40.
Overall, the graph demonstrates that:
- hCG dominates early pregnancy and then declines
- Progesterone and estrogen increase steadily and become the dominant hormones in later pregnancy
Figure 8.4.4: Stages of Childbirth
This image is a multi‑panel diagram illustrates the three stages of labor and delivery: dilation, birth, and afterbirth.
Stage 1: Dilation - Two side‑by‑side illustrations show the uterus and fetus. An arrow indicates progression from an undilated to a fully dilated cervix.
- On the left, the cervix is labeled “Undilated cervix.” The opening is small and closed at the top of the vagina. Labels identify Amniotic fluid within uterus, Cervix, and Vagina.
- On the right, the cervix is labeled “Fully dilated cervix (greater than 10 cm in diameter).” The opening is wide, allowing passage of the fetus.
Stage 2: Birth - Four sequential panels show the delivery of the baby. Arrows between panels show the sequence of movement through the birth canal.
- “Presentation of head” – The fetus is positioned head‑down, with the head entering the birth canal.
- “Rotation and delivery of anterior shoulder” – The head rotates as the front shoulder emerges.
- “Delivery of posterior shoulder” – The second shoulder passes through the birth canal.
- “Delivery of lower body and umbilical cord” – The rest of the body is delivered, followed by the umbilical cord.
Stage 3: Afterbirth delivery - Two images show the placenta after the baby is delivered:
- The diagram on the left shows the placenta detaching from the uterine wall and moving toward the cervix. A label reads: “Placenta detaches and exits through vagina.”
- The image on the right is a photograph of an expelled placenta placed in a medical tray, showing its tissue structure and attached umbilical cord.
Figure 8.5.1: Neonatal Circulatory System
This image compares fetal circulation before birth with the circulation pattern immediately after birth. The top panel focuses on changes within the heart, while the bottom panel shows changes in blood flow between the placenta, liver, and circulatory system.
Before birth, fetal blood bypasses the lungs because oxygen is obtained from the placenta. In the heart, blood can flow directly from the right atrium to the left atrium through the foramen ovale, and blood leaving the right ventricle can bypass the lungs through the ductus arteriosus, a vessel connecting the pulmonary trunk to the aorta. Colored arrows illustrate these fetal shunts and the movement of blood through the fetal cardiovascular system.
Immediately after birth, when the newborn begins breathing, these bypass pathways close. The ductus arteriosus constricts, directing blood from the right ventricle to the lungs through the pulmonary arteries for oxygenation. The foramen ovale closes, leaving a depression called the fossa ovalis, which separates oxygen-poor and oxygen-rich blood within the heart.
The lower panel illustrates changes in circulation associated with the placenta. Before birth, oxygenated blood enters the fetus through the umbilical vein and travels partly through the ductus venosus, which allows blood to bypass most of the liver and enter the inferior vena cava. After birth, placental circulation ends when the umbilical cord is no longer used. The ductus venosus closes and becomes the ligamentum venosum, the umbilical vessels are converted into ligaments, and the inferior vena cava carries only deoxygenated blood returning to the heart.
This figure demonstrates how the circulatory system transitions from fetal circulation, which relies on the placenta and several temporary vascular shunts, to newborn circulation, which depends on the lungs for oxygen exchange and uses the normal postnatal pathway of blood flow through the heart, lungs, and body.
Figure 8.6.1: Let-Down Reflex
This image illustrates the positive feedback loop that regulates lactation, showing how infant suckling stimulates both milk production and milk ejection.
At the top of the figure, an infant suckles at the breast. Sensory receptors in the areola detect suckling and send nerve impulses to the brain. These signals travel to the hypothalamus and posterior pituitary gland, which respond by releasing oxytocin into the bloodstream. An inset diagram shows oxytocin-producing neurosecretory cells in the hypothalamus connected to the posterior pituitary through the hypothalamo-hypophyseal tract, where oxytocin enters nearby capillaries and is carried throughout the body.
At the same time, sensory stimulation from suckling promotes milk production within the mammary glands. In the right panel, mammary alveoli are shown producing milk. The alveoli are lined with lactocytes, specialized cells that synthesize and secrete milk into the hollow interior of each alveolus. Arrows indicate milk accumulating within these structures.
As circulating oxytocin reaches the breast, it stimulates myoepithelial cells surrounding the alveoli to contract. This contraction squeezes milk from the alveoli into the lactiferous ducts. A diagram of breast tissue shows milk moving through branching ducts toward the nipple. Milk collects temporarily in the lactiferous sinus before leaving the breast through openings in the nipple, where it becomes available to the nursing infant.
The left side of the figure shows a large arrow forming a loop labeled as a positive feedback cycle. As milk is produced and released, the infant continues to suckle. Continued suckling generates additional sensory stimulation, which promotes further oxytocin release and ongoing milk production and ejection. The result is a self-reinforcing cycle in which suckling increases milk availability, and increased milk availability encourages continued suckling.
This figure demonstrates how lactation is regulated through a positive feedback mechanism: infant suckling stimulates neural and hormonal responses that increase milk production and milk letdown, which in turn encourages further suckling and sustains the cycle.
Figure 8.7.1: A Human Karyotype
This image shows a human karyotype, which is an organized display of chromosomes arranged in numbered pairs. The chromosomes are shown as small, rod‑shaped structures with banding patterns, grouped into pairs and labeled below each pair with numbers. Across the image, there are 22 numbered pairs of autosomes, labeled sequentially from 1 through 22. Each numbered group contains two chromosomes of similar size and shape, indicating homologous pairs.
- Chromosomes 1 through 3 appear largest and are shown at the top left.
- Chromosomes gradually decrease in size from left to right and top to bottom.
- Chromosomes 13 through 15 and 21 through 22 appear smaller and more compact.
At the bottom right, a final pair is labeled “X/Y”, representing the sex chromosomes. One chromosome is larger (X), and the other is smaller (Y), indicating a typical male karyotype. Each chromosome pair shows characteristic dark and light banding patterns, which reflect regions of differing DNA composition.
Figure 8.7.2: Random Segregation
This image illustrates inheritance of a trait controlled by one dominant allele and one recessive allele across two generations using Punnett squares.
In the first generation, a parent with two dominant alleles is crossed with a parent that has two recessive alleles. The Punnett square shows that every possible offspring receives one dominant allele from one parent and one recessive allele from the other parent. As a result, all offspring are heterozygous and express the dominant trait. The figure indicates that 100 percent of the second-generation offspring display the dominant phenotype.
In the second generation, two heterozygous individuals are crossed. Each parent can contribute either a dominant allele or a recessive allele. The Punnett square shows four possible offspring combinations. One offspring inherits two dominant alleles, two offspring inherit one dominant and one recessive allele, and one offspring inherits two recessive alleles. This produces a genotypic ratio of 1 homozygous dominant, 2 heterozygous, and 1 homozygous recessive.
Because both homozygous dominant and heterozygous individuals express the dominant trait, three of the four possible offspring display the dominant phenotype. Only the offspring with two recessive alleles expresses the recessive phenotype. The figure summarizes this outcome as 75 percent dominant phenotype and 25 percent recessive phenotype.
This figure demonstrates Mendel’s principle of inheritance for a single gene, showing that crossing two true-breeding parents produces a generation of heterozygous offspring and that crossing those heterozygous offspring results in a 3:1 dominant-to-recessive phenotype ratio and a 1:2:1 genotype ratio in the next generation.
Figure 8.7.3: Autosomal Dominant Inheritance
This image illustrates inheritance of neurofibromatosis using a Punnett square. The disorder is associated with a dominant allele, meaning that a person needs only one copy of the disease-associated allele to express the condition.
The cross shown involves a parent who carries one disease-associated dominant allele and one normal recessive allele and a second parent who carries two recessive alleles and does not have the condition. The parent with the dominant allele can pass either the disease-associated allele or the recessive allele to offspring, whereas the unaffected parent can pass only recessive alleles.
The Punnett square shows four possible offspring outcomes. Two of the four offspring inherit the disease-associated dominant allele from the heterozygous parent and a recessive allele from the unaffected parent. These offspring have neurofibromatosis because the dominant allele is expressed. The other two offspring inherit recessive alleles from both parents and therefore do not have the condition.
The figure summarizes the results as a 50 percent probability that offspring will inherit neurofibromatosis and a 50 percent probability that offspring will not inherit the disorder.
This figure demonstrates the inheritance pattern of an autosomal dominant disorder. When an affected heterozygous parent and an unaffected parent have children, each child has a one-in-two chance of inheriting the dominant disease-associated allele and expressing the condition, and a one-in-two chance of inheriting only recessive alleles and remaining unaffected.
Figure 8.7.4: Autosomal Recessive Inheritance of Cystic Fibrosis
illustrates autosomal recessive inheritance using cystic fibrosis as an example. Two carrier parents are shown at the top of the figure. Each parent carries one normal allele and one recessive disease-associated allele but does not have cystic fibrosis because the normal allele masks the effect of the recessive allele.
Lines connect the parents to four possible offspring outcomes. One offspring inherits a normal allele from each parent and is unaffected and does not carry the disease-associated allele. Two offspring inherit one normal allele and one recessive disease-associated allele. Like the parents, these offspring are carriers who do not show symptoms but can pass the allele to future generations. One offspring inherits two recessive disease-associated alleles and is affected with cystic fibrosis.
A Punnett square on the right summarizes these possible genetic combinations. The results show one offspring with two normal alleles, two carrier offspring with one normal and one recessive allele, and one affected offspring with two recessive alleles. This produces a genotypic ratio of 1 unaffected non-carrier : 2 carriers : 1 affected individual.
The figure also summarizes the phenotypic outcomes. Three of the four possible offspring do not express cystic fibrosis because they inherit at least one normal allele. One of the four offspring inherits two recessive disease-associated alleles and expresses cystic fibrosis. This corresponds to a 75 percent probability that cystic fibrosis is not expressed and a 25 percent probability that the disorder is expressed.
This figure demonstrates the inheritance pattern of an autosomal recessive disorder. When two carrier parents have children, each child has a 25 percent chance of being unaffected and not a carrier, a 50 percent chance of being an unaffected carrier, and a 25 percent chance of inheriting two recessive alleles and developing the disorder.
Figure 8.7.5: X-Linked Dominant Inheritance Patterns
This image illustrates two inheritance patterns for an X-linked dominant trait, comparing the outcomes when either the father or the mother carries the affected allele.
Panel (a): Affected father and unaffected mother
The first example shows a father who has an X-linked dominant trait and a mother who does not have the trait. Because fathers pass their X chromosome only to their daughters and their Y chromosome only to their sons, all daughters inherit the affected X chromosome and express the trait. None of the sons inherit the affected X chromosome because they receive the Y chromosome from the father. As a result, all daughters are affected and all sons are unaffected.
The figure summarizes these outcomes as 100 percent of females affected and 0 percent of males affected.
Panel (b): Unaffected father and affected mother
The second example shows a father without the trait and a mother who carries one affected X chromosome and one unaffected X chromosome. Each child has a 50 percent chance of inheriting the affected X chromosome from the mother. Sons who inherit the affected X chromosome express the trait because they have only one X chromosome. Daughters who inherit the affected X chromosome also express the trait because the allele is dominant. The remaining sons and daughters inherit the unaffected X chromosome and do not express the trait.
The figure summarizes these outcomes as 50 percent of males affected and 50 percent of females affected.
This figure demonstrates the characteristic inheritance pattern of X-linked dominant traits. An affected father passes the trait to all daughters and none of his sons, whereas an affected heterozygous mother can pass the trait to approximately half of both sons and daughters.
Figure 8.7.6: X-Linked Recessive Inheritance with a Carrier Mother
This image illustrates the inheritance pattern of an X-linked recessive trait when an unaffected father and a carrier mother have children.
The father does not carry the recessive disease-associated allele. The mother carries one normal X chromosome and one X chromosome with the recessive allele, making her a carrier who does not express the condition.
The figure shows four possible offspring outcomes. One son inherits the mother's normal X chromosome and is unaffected. A second son inherits the mother's X chromosome carrying the recessive allele and is affected because males have only one X chromosome and therefore cannot mask the recessive allele. One daughter inherits normal X chromosomes from both parents and is unaffected. Another daughter inherits the recessive allele from the mother and a normal X chromosome from the father, making her a carrier who does not express the condition.
The figure demonstrates that daughters are not affected because they inherit a normal X chromosome from the unaffected father. However, some daughters may become carriers if they inherit the recessive allele from the mother. Sons inherit their single X chromosome from the mother, so a son who receives the recessive allele expresses the trait.
The probability summary indicates that 50 percent of sons are affected and 50 percent of sons are unaffected, while 0 percent of daughters are affected, although 50 percent of daughters are carriers.
This figure demonstrates the characteristic inheritance pattern of an X-linked recessive trait when the mother is a carrier and the father is unaffected. Sons have a 50 percent chance of inheriting and expressing the trait, whereas daughters are not affected but may inherit the recessive allele and become carriers.
This page titled 8.11: Alternate Text Descriptions was last modified on Sat, 26 Sep 2026 20:13:26 GMT and is shared under a CC BY 4.0 license and was authored, remixed, and/or curated by Lakshmikanta Sengupta and Susmita Sengupta.
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