# Anaesthetic-Tricaine-Acts-Preferentially-on-Neural-Voltage-Gated-Sodium-Channels-and-Fails-to-Block-pone.0103751.s001

Movement of wild type (wt), fixe mutants (chrndsb13/sb13) or fixe sibling (chrndsb13/+ or chrnd+/+) fish in response to EES. Fish were treated with the water control or tricaine at standard or fivefold dose, as indicated before each clip. A pulse train of 0.1 s duration was applied every 5 seconds. Movie is sped up about 2.5-fold for ease of viewing. Note increased movement in response to the first pulse, possibly reflecting the need for channel activation for tricaine to bind to Nav channels. Heartbeat shows all fish are alive. In ‘fixe + 5X tricaine' clip, heartbeat shows fish are alive but fail to respond to stimulation.

- Kind: Short
- Year: 2014
- Runtime: 1 min
- By: Attili S, Hughes S
- Archive: [Wikimedia Commons](https://commons.wikimedia.org/wiki/File:Anaesthetic-Tricaine-Acts-Preferentially-on-Neural-Voltage-Gated-Sodium-Channels-and-Fails-to-Block-pone.0103751.s001.ogv)
- Licence or status: [CC BY 4.0](https://creativecommons.org/licenses/by/4.0) (as the archive states it)
- Credit: Attili S, Hughes S
- Who can watch: Teens profiles and older (the archive gives no rating; placed by Invisible Network from its collection and subjects)

[Watch now](https://invisiblenetwork.ai/watch/archive/commons/34613938?play=1)