# Low-Grade Serous Ovarian Cancer — 5-Minute Journal Club: Microlearning Activity 1

An episode of [Research To Practice | Oncology Videos](https://invisiblenetwork.ai/podcast/699146770), 13 Sep 2026, 29 min.

Audio: https://traffic.libsyn.com/secure/researchtopractice/Grisham_7-14-26_V6TW_Issue_1_480.mp4?dest-id=1103750

Featuring perspectives from Dr Rachel N Grisham, including the following topics: • Mechanism, clinical evidence and practical use of avutometinib with defactinib for recurrent low-grade serous ovarian cancer (LGSOC) (0:00) • A Phase III trial of letrozole alone as front-line treatment for LGSOC (11:11) • Current and future role of avutometinib with defactinib for LGSOC (19:23) • A Phase II/III trial of trametinib for recurrent LGSOC: Biomarker analyses and clinical implications (21:37) CME information and select publications

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