# Prostate Cancer with PTEN Deficiency — An Interview with Dr Neeraj Agarwal (Companion Faculty Lecture)

An episode of [Research To Practice | Oncology Videos](https://invisiblenetwork.ai/podcast/699146770), 2 Oct 2026, 24 min.

Audio: https://traffic.libsyn.com/secure/researchtopractice/Agarwal_Neeraj_8-24-26_Presentation_V1FC_480.mp4?dest-id=1103750

Featuring a slide presentation and related discussion from Dr Neeraj Agarwal, including the following topics: • Therapeutic targets of systemic therapy in prostate cancer (0:00) • Prevalence of genomic alterations in prostate cancer including PTEN deficiency; prognostic and predictive value (3:52) • Optimal timing of and approach to PTEN assessment; pathophysiology surrounding PTEN loss (9:29) • Comparison of ipatasertib and capivasertib; key findings from Phase III IPATential150 and CAPItello-281 studies (14:26) • Safety and tolerability profile of capivasertib; strategies for management of adverse events (19:21) CME information and select publications

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