# TWiV 1289: Building a better hepatitis B trap

An episode of [This Week in Virology](https://invisiblenetwork.ai/podcast/300973784), 18 Jan 2026, 1 h 42 min.

Audio: https://traffic.libsyn.com/secure/twiv/TWiV1289.mp3?dest-id=25528

TWiV explains how the dengue virus protein NS1 alters Aedes aegypti midgut permeability and favors virus dissemination, and achieving a complete hepatitis B virus cure in chronic hepatitis B virus-infected humanized mice by using a capsid assembly modulator. Hosts: Vincent Racaniello, Alan Dove, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode • Support science education at MicrobeTV • ASV 2026 • Positions in Rosenfeld Lab (email) • Dengue virus NS1 alters mosquito midgut permeability (mBio) • HBV cure with a capsid assembly modulator (Cell Host Microbe) • Letters read on TWiV 1289 • Timestamps by Jolene Ramsey. Thanks! Weekly Picks Angela – How hibernating bears maintain muscle mass Alan – The flood of Chinese grad students in the 2000s was a boon to US students. Vincent – Feynman Lectures on Physics Listener Picks David – Stewart Cheifet, Host of TV’s ‘Computer Chronicles,’ Dies at 87 Charles – Last Year, and the Year to Come Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

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