# INTRO TO LOCAL ANESTHETICS - MECHANISM, STRUCTURE, USES & SIDE EFFECTS │ EP22

An episode of [Atomic Anesthesia](https://invisiblenetwork.ai/podcast/1753488560), 19 Jan 2025, 29 min.

Audio: https://podcasts.captivate.fm/media/cf5dd4cd-ef0d-492e-b92a-cc8e17b413ff/Intro-to-Local-Anesthetics-COMPLETED-MP3.mp3

In this episode, Professor Rhea Temmermand gives nurse anesthesia residents and aspiring CRNA students a introduction to the pharmacology of LOCAL ANESTHESIA. Discover the fundamental structure, classification, and mechanism of action of these essential drugs, including how they block voltage-gated sodium channels to prevent pain signal transmission. Learn about the critical concept of pKa and its impact on drug effectiveness, explore the pharmacokinetics of esters and amides, and understand key clinical considerations for various administration routes. Professor Temmermand also covers crucial safety aspects, including recognizing and managing local anesthetic systemic toxicity (LAST). Whether you're preparing for boards or enhancing your clinical practice, this episode provides invaluable insights into the pharmacology and practical application of local anesthetics in anesthesiology. 💜 LIVE WEBINAR: Save your seat on our monthly, free webinars. Replays are sent to your inbox and you get access to all of our previous webinars. \[WEBINAR SIGN UP\] 💜 FREE DOWNLOADS: Grab your copy of customized study plans & worksheets. \[SEE/NCE STUDY PLAN\] \[RN ICU DRUG CHART\] 💜 CONNECT: 📥 Email questions, comments or topic suggestions to Dr. Temmermand at hello@atomicanesthesia.com, follow us on social media, and sign up for our launch newsletter ⬇️ \[NEWSLETTER SIGN-UP\] \[INSTAGRAM\] \[TIKTOK\] \[YOUTUBE\]

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