# Understanding Haploinsufficiency of A20

An episode of [ACR on Air](https://invisiblenetwork.ai/podcast/1473160907), 14 Jul 2026, 44 min.

Audio: https://traffic.libsyn.com/secure/acronair/Ep_128.mp3?dest-id=1238600

What if some patients who never quite fit their diagnosis actually have an underlying genetic disorder? In this episode, we explore Haploinsufficiency of A20 (HA20), a condition first described less than a decade ago that is already reshaping our understanding of autoinflammation, autoimmunity, and immune dysregulation. How many patients in our clinics have a genetic diagnosis we've never thought to consider? Join us as we discuss this emerging disease and its clinical implications with Dr. Daniella M. Schwartz.

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