# #135 Guideline Directed Medical Therapy Part II: 5 Pearls Segment

An episode of [Core IM | Internal Medicine Podcast](https://invisiblenetwork.ai/podcast/1297791208), 20 Sep 2023, 37 min.

Audio: https://pscrb.fm/rss/p/audio2.redcircle.com/episodes/c14e662c-2714-44c5-bbf2-7c0c5bb0bbae/stream.mp3

With progressing CKD & HFrEF, what GDMT medications can you start, continue or stop? What does the data on hydralazine/isosorbide tell us and what does it NOT tell us? What are the pros and cons of starting GDMT inpatient versus outpatient? Do you still keep patients on GDMT once their EF recovers? Sponsors: Hellofresh | Pranay's Effective Living Formula Course Pranay's Free Masterclass (Sept 20 and 27th at 5pm PST) CME : http://bit.ly/CIMCME || Show Notes & Transcript Timestamps • 01:54 Pearl 1 – Recap of GDMT and CKD • 09:15 Pearl 2 – Hydralazine and Isosorbide Dinitrate • 20:59 Pearl 3 – Ivabradine • 25:47 Pearl 4 – Inpatient vs Outpatient Initiation of GDMT • 30:55 Pearl 5 – Ejection Fraction Recovery Tags: IMCore, CoreIM, hydralazine, heart failure reduced ejection fraction, HFmrEF, HFimpEF, chronic kidney disease, cardiology Find the best disability insurance for you: https://www.patternlife.com/disability-insurance?campid=497840 Our Sponsors: * Check out Eko: https://ekohealth.com * Check out FIGS and use my code FIGSRX for a great deal: https://wearfigs.com Advertising Inquiries: https://redcircle.com/brands Privacy & Opt-Out: https://redcircle.com/privacy

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