# No.1 Sleep Expert: Magnesium Isn’t Helping You Sleep! This Sleep Habit Increases Heart Disease 57%

An episode of [The Diary Of A CEO with Steven Bartlett](https://invisiblenetwork.ai/podcast/1291423644), 17 Nov 2025, 2 h 18 min.

Audio: https://pdst.fm/e/pscrb.fm/rss/p/mgln.ai/e/1390/claritaspod.com/measure/p.podderapp.com/2544644999/mgln.ai/e/1651/episode.flightcast.com/01KA16HD3NWCWR2143WFAXDWK5.mp3

No.1 Sleep Expert DR. MATTHEW WALKER reveals how to fix insomnia, reset your circadian rhythm, deepen REM sleep, and why magnesium and melatonin may be hurting your sleep. Dr Matthew Walker is a Professor of Neuroscience and Psychology at the University of California, Berkeley, and one of the world’s leading experts on sleep science, with over 20 years of research. He is host of The Matt Walker Podcast and bestselling author of ‘Why We Sleep: The New Science of Sleep and Dreams’. He explains: ◼️The shocking link between poor sleep timing and increased cancer risk ◼️How alcohol and caffeine silently sabotage deep sleep and mental performance ◼️Why screen time and light exposure before bed are secretly rewiring your brain ◼️How “sleep banking” before stress, travel, or work sprints can boost resilience ◼️Why parents, professionals, and athletes all need radically different sleep strategies Enjoyed the episode? Share it using this link and get points for every referral: https://doac-perks.com (00:00) Intro (02:33) Sleep Changes Your DNA (05:01) The Stigma Around Sleep and Laziness (08:43) What’s Stopping People From Sleeping? (10:58) The Shocking Link Between Weekend Sleep-Ins and Heart Disease (14:48) New Research: Sleep Banking for Low-Sleep Periods (16:25) Boost Cognitive Performance With This Sleep Hack (19:14) 3 Things That Will Improve Your Sleep Quality Tonight (20:42) It’s Not Blue Light That’s Keeping You Awake (22:01) Melatonin Doesn’t Make You Sleep — Here’s What It Does (24:28) The Right Amount of Melatonin (25:55) The 1% With Nocturnal Clocks Who Can’t Sleep Until 3 AM (27:26) Should You Be Concerned About Melatonin as a Sleep Aid? (30:33) The Trade-Offs in Sleep Medicine (35:05) The Key to a Digital Detox (35:46) The 4 Macros of Good Sleep: QQRT (37:02) The Minimum Amount of Sleep You Need to Stay Alive (42:49) How Sleep Regularity Predicts Life Expectancy (46:50) Try This 7-Day Sleep Enhancer Challenge (53:24) Is Your Room Dark Enough for Optimal Sleep? (1:01:03) Why Counting Sheep Doesn’t Work (1:02:58) A Better Alternative to Counting Sheep (1:04:36) Does Magnesium Really Help With Sleep? (1:11:47) Ads (1:13:33) How REM Sleep Works and How to Maximize It (1:20:30) Why REM Sleep Is So Important (1:22:07) Entering a ‘Psychotic’ State During Dreams (1:25:05) Healing Trauma Through Dreams (1:31:12) Nightmares as a Warning Sign of Mental Health Issues (1:36:09) REM Sleep Is Like Group Therapy for Memories (1:39:31) Ads (1:41:18) The Dystopian Future: Superhumans Who Sleep Only 6 Hours (1:45:17) Could Humans Be Engineered to Sleep Less? (1:50:20) Why Undersleeping Triggers Cravings (1:54:36) A New Drug That Could Help With Insomnia (2:03:50) What Did Success Bring You? (2:07:33) I Didn’t Believe in Finding “The One” (2:28:39) The Future of AI and Sleep Follow Dr Matthew: X - https://bit.ly/4oIRpAY Instagram - https://bit.ly/49OgFB4 Podcast - https://bit.ly/489MJhA You can purchase Dr Matthew’s book, ‘Why We Sleep’, here: https://amzn.to/3K04IxJ Independent Fact Check: https://stevenbartlett.com/wp-content/uploads/2025/11/DOAC-Matthew-Walker-2-Independent-Research-further-reading.pdf The Diary Of A CEO: ◼️Join DOAC circle here - https://doaccircle.com/ ◼️Buy The Diary Of A CEO book here - https://smarturl.it/DOACbook ◼️The 1% Diary is back - limited time only: https://bit.ly/3YFbJbt ◼️The Diary Of A CEO Conversation Cards (Second Edition): https://g2ul0.app.link/f31dsUttKKb ◼️Get email updates - https://bit.ly/diary-of-a-ceo-yt ◼️Follow Steven - https://g2ul0.app.link/gnGqL4IsKKb Sponsors: Linkedin Ads - https://www.linkedin.com/DIARY Pipedrive - http://pipedrive.com/CEO KetoneIQ - Visit https://ketone.com/STEVEN for 30% off your subscription order Last chance to join the waitlist for the limited edition Diary Of A CEO Conversation Cards here: https://bit.ly/cardswaitlist

## Transcript

[0:00] Here's the problem with magnesium supplementation when it comes to sleep.
[0:03] The first thing to note is that most forms of magnesium don't cross the blood brain barrier
[0:07] and sleep is produced by your brain, so how can something that doesn't get into your brain affect
[0:13] brain process? All you're doing is creating probably expensive urine.
[0:18] However, there is one form of magnesium that seems to have some evidence in favor of it,
[0:23] which we can speak about, but it doesn't stop there. There's so much new evidence that we have,
[0:27] including this myth of eight hours, my fear about giving a melatonin to kids,
[0:31] why you keep waking up in the middle of the night, and the invention of the first new class
[0:37] of sleeping medication that I actually favor, and most people are not aware of it.
[0:42] Matthew Walker is back, and the world-renowned sleep expert and neuroscience professor
[0:47] is sharing brand new research to combat the sleep loss epidemic and help you get the perfect night's
[0:53] sleep. It's a society. We have struggles with sleep at night due to many reasons,
[0:56] but no one teaches us this stuff, and it's things like, so you go to bed at 11, one night,
[1:02] one a.m., the next night, then 10, 30 p.m., the next night, and it's remarkable how many people do this.
[1:07] Look, studies have shown that you are statistically 49% more likely to prematurely die,
[1:12] versus those people who were most regular in terms of going to bed and waking up at the same time,
[1:17] and worse, they had a 57% cardio-metabolic disease risk increase.
[1:22] What the? Science really teaches us that there are four pillars of good sleep,
[1:26] and then there's this incredible new study looking at sleep banking, and this is remarkable for
[1:30] people who are facing a sprint at work or a medical doctor about to go on call for the next 40
[1:35] hours, new parents, and we can go through all of that. But if you were to push me to say the three
[1:39] most impactful things that you can start doing tonight to start sleeping better, it would be...
[1:47] Just give me 30 seconds of your time. Two things I wanted to say. The first thing is a huge thank you
[1:54] for listening and tuning into the show, week after week, means the world to all of us, and this
[1:58] really is a dream that we absolutely never had, and couldn't have imagined getting to this place.
[2:03] But secondly, it's a dream where we feel like we're only just getting started.
[2:07] And if you enjoy what we do here, please join the 24% of people that listen to this broadcast
[2:12] regularly and follow us on this app. Here's a promise I'm going to make to you. I'm going to do
[2:17] everything in my power to make this show as good as I can now and into the future. We're going to
[2:22] deliver the guests that you want me to speak to, and we're going to continue to keep doing all of the
[2:26] things you love about this show. Thank you. Dr. Matthew Walker. Here in front of me, I have
[2:37] these cards, which I'm going to reveal a bit later, but these kind of hold what you consider to
[2:41] be the four pillars of great sleep. But you also spend much of your professional career just studying
[2:48] the brain generally to understand human performance and how we can change our lifestyles and also
[2:53] introduce some of these new sort of treatments to improve how our brain performs. I want to talk
[2:58] about all of that as well. But to start, for anyone that is unfamiliar with you and has been hiding
[3:03] under a rock, how do you summarize who you are professionally, the sort of academic references
[3:10] you're drawing on and the experiences and research you've done so that the viewer listening at home
[3:16] understands the full world that you operate in study and have experienced.
[3:21] I am in your scientist by trade, but my specialty is sleep, the effects of sleep on the brain
[3:27] and the body. And I've probably spent about the past two decades trying to understand exactly
[3:33] why do we sleep? Because 50 years ago, the crash answer to the question, why do you sleep?
[3:40] Where's the following? You sleep to cure sleepiness, which is the fact your equivalent of saying,
[3:46] well, you eat to cure hunger. No, you don't eat to cure hunger. You eat to support all sorts of
[3:53] physiological and biological benefits. But now, and this is not due to my research, this is all of
[3:59] the incredible colleagues who sort of shoulders that I stand on. We've now had to upend the question.
[4:05] We now have to ask, is there any major physiological system in your body or is there any
[4:10] operation of your mind that isn't wonderfully enhanced by sleep when you get it or demonstrably
[4:15] impaired when you don't get enough? And the answer now seems to be, no, there is no such system,
[4:22] even down to the level of your DNA, your sleep and how you are sleeping or not sleeping,
[4:29] will change the very DNA nucleic alphabet that spells out your daily health narrative.
[4:37] And we can see it all the way up to society. Sleep can change the fabric of society,
[4:42] can change how we interact with other people, it can change our belief systems, it can change how
[4:48] lonely or sort of hypersocial we are. So to your question, I'm a sleep scientist by trade and
[4:55] I suppose my mission has been trying to reunite humanity with the sleep that it seems to be so
[5:00] bereft of. We had a fantastic conversation last time and my audience valued it tremendously,
[5:06] I know that because we often survey our audience and we get to see some of the back end stats.
[5:11] And this conversation about sleep is particularly personal to everybody listening because
[5:15] when we surveyed our audience head of this conversation today, about 75 or 80% of the
[5:20] diavisio audience struggle with sleep for a variety of different reasons. So we actually asked
[5:25] them a thousand of them their questions to ask you today. But also the other reason I really
[5:30] want to chat to you is the science of sleep. I mean, as is the way of science is always evolving.
[5:35] We're learning new things and even since we spoke last time, there is new sleep science which we're
[5:39] going to talk about today. And one of those particular things we're going to talk about is going
[5:42] to be demonstrated using this job because I always want to know what the updated sleep sciences
[5:49] so that I can be a better sleeper because I agree with everything you've said about how
[5:53] foundational sleep is in my life. And I didn't know this at the start of my career. I didn't
[6:00] know this even a couple of years ago, five years ago. I didn't know. I thought sleep was one of
[6:04] those things you could just take it or leave. Yeah. I mean, it's not your fault in so many ways
[6:10] because if you didn't know what I know, you would just think, well, when I sleep, my body is dormant
[6:16] and my mind for the most part is blank. So is it so catastrophic to lose an hour or two
[6:24] of sleep and you have to then think about from an evolutionary perspective, it is such an
[6:31] idiotic idea to sleep because when you're sleeping, you're not finding a mate, you're not reproducing,
[6:37] you're not caring for your young, you're not foraging for food, and worse of all, you're vulnerable
[6:41] to predation. So on any one of those grounds, and especially all of them as a collective, sleep
[6:46] should have been strongly selected against in the course of evolution. And my point is that,
[6:52] and it's often being said that if sleep doesn't serve an absolutely vital set of functions plural,
[6:57] then it's the biggest mistake the evolutionary processes ever made. And we now realize it didn't
[7:01] make a spectacular blunder. But really, I guess the point of it is, sleep is not a passive state.
[7:09] It's an incredibly active state, both in the terms of the brain and the body. And so you should not
[7:16] feel remiss or ashamed that you didn't value the importance of sleep because firstly,
[7:22] as a subjective sense, you just think, well, my mind was offline for a while.
[7:27] Second, we also know that we don't teach the importance of sleep in education. And doctors
[7:32] themselves, you know, there's a great study and they, what they found was that medical doctors
[7:36] across, I think it was about 11 different curricula around the world. They will only receive about
[7:41] 1.2 hours of education on sleep. But it's a third of their patients' lives. So there's a collection of
[7:52] almost perfect storms that have happened to keep society ignorant of the importance and the
[7:59] value of sleep. I think that's why we often so short-change it together with also something
[8:05] terrible, which is stigma, that people are so proud to say, well, I've been eating really healthy
[8:13] the past couple of months or, you know, I've been going to the gym three times a week consistently
[8:18] for the past year. No one is ever going out into society and saying, you know, I've been getting
[8:24] eight and a half hours of sleep consistently every night because if you did, people would say
[8:29] really. And there's a slight edge to the really, which is that if you have time to sleep,
[8:37] then you must not be busy. And if you're not busy, you must not be important.
[8:43] So can you do me a favour? And for the listener at home, can you tell me what the different
[8:49] groups of people that are listening to this conversation right now are seeking? From the extreme end
[8:55] being, sleep out in the air, I get no sleep, I'm an insomniac, to the other end where maybe they're
[9:01] looking for marginal performance gains. Like, what are the cohorts of people you see and the
[9:05] reasons why they're so interested in your work? They listen to your podcast, they read your books.
[9:08] What are the cohorts? Firstly, we have the collection of people who have insomnia,
[9:13] those people who have other sleep disorders like sleep apnea, which we can speak about.
[9:17] There's another disorder called restless leg syndrome. It's a terrible disorder where your legs start
[9:22] to feel as though they've got this sort of creepy, crawly feeling and you've constantly got to massage
[9:26] them and move them. It's a terrible disruptor of your sleep. All of these disorders are markedly
[9:31] undiagnosed, by the way. And then you've got another collection of individuals who they don't
[9:39] have any sleep disorders, but they are either doing things that will dismantle their sleep. So
[9:46] either they're taking on things into themselves, like alcohol, caffeine, THC, that aren't the
[9:53] sleep helpers, even though sometimes they think they are. And then you've got perhaps the internal
[9:59] things that will prevent you from sleeping well, things like stress and anxiety.
[10:04] And then you've also just got life itself that can get in the way. And then moving from the sleep
[10:11] disorders realm to the, I don't have a sleep disorder, but I'm probably not doing it right,
[10:16] quote unquote, when it comes to sleep. Then you've got the people who are obsessed about getting
[10:22] it right. And they are the bio optimizers, the bio hackers. And then you've also got, I work with
[10:30] a lot of high performance individuals who are really trying to just scratch out those last
[10:36] couple of percentages. Either it's in business or often we're working with professional athletes.
[10:42] These are the people for whom two or three percentage point changes can be tens of millions of
[10:49] dollars or they can be the difference between standing on a podium at the Olympics or not. And so
[10:55] this is a broad collection of wonderful characters. And since we last spoke, is there now a lot
[11:01] of new sleep science and understanding as it relates to sleep performance and these three
[11:06] categories of sleep deficient sleep disorders lifestyle factors and then the optimizers?
[11:11] Yeah, I think there's there's a broad collection of new evidence that we have. But maybe let me
[11:17] come on to the middle group. You know, I used to say that for people who were deficient in their
[11:23] sleep, that sleep wasn't like the bank that you can't accumulate a debt. Oh, here we go. Okay.
[11:32] So what we can see here is that the jaw used to be full full of sleep credit when you're sleeping well.
[11:38] And then during the week, I'm short sleeping. So maybe I'm only getting five hours a night. So
[11:44] I'm constantly going into debt. So I'm losing all of this wonderful sleep credit and my system is
[11:50] building up this collateral debt. And then we used to think that sleep was not like the bank that
[11:57] once you've gone into debt, unfortunately, the latest closed and even at the weekend, if you try
[12:05] to pay it back, you can't put back credit into the system. However, there was a study published
[12:13] from what's called the UK Biobank, which is this incredible data set. It's revolutionary. And they
[12:19] studied in this particular research paper over 90,000 individuals. And what they did was they
[12:26] essentially split them down into those individuals who were short sleeping during the week and then
[12:32] short sleeping at the weekend. And they compared them to those individuals who were short sleeping
[12:37] during the week. But then long sleeping at the weekend, they were doing catch up sleep.
[12:41] That's me. And that's so many individuals. It turns out, if you look at the data, it's remarkable
[12:46] how many people do this. There's catch up sleep behavior. But what was amazing is that in the people
[12:52] who were short sleeping during the week, but long sleeping at the weekend, they had a 20% reduced
[12:58] cardiovascular disease risk relative to the people who were short sleeping during the week,
[13:03] but also short sleeping at the weekend. Now, to be clear, both of those groups had a higher
[13:10] cardiovascular disease risk than people who were sleeping sufficiently during the week and
[13:15] sleeping sufficiently during the weekend. So I'm not saying that it's a completely free lunch.
[13:20] But for the first time, we realized that at least one system, major organ system in your body
[13:27] is like the bank, which is that if your heart at the weekend,
[13:32] you can just keep putting credit back. And your system doesn't suffer as much.
[13:43] For your heart. For your heart. Okay. But again, many of the other major physiological systems
[13:49] don't show that. So work by people like Kenneth Wright at the University of Boulder, Colorado,
[13:54] he shown that your immune system doesn't rebound after long sleep at the weekend,
[13:58] your regulation of blood sugar, your cognitive ability. So that's one way in which I've changed
[14:04] my mind regarding sleep in the bank. But there's a very different new set of data that has changed
[14:10] my mind completely about this idea of sleep and the bank. Now, what we've just discussed here is to
[14:17] say, I went into debt and then I was hoping to try and pay it off with credit at the weekend.
[14:24] So the jar represents the debt that you have, the sleep bread. And what I'm trying to do is force more
[14:30] coinage in at the weekend to see if I can offset the debt that I created and get back to net, net
[14:41] neutral by the end of the weekend. Now, it turns out you can't do that even if you sleep for as long
[14:47] as you want. But here's this new remarkable data. It came from Walter Reed Medical Army Institute
[14:54] a research called Thomas Balkan and what he was interested in was flipping the direction of the
[14:59] question. Not if I go into debt can I pay back with credit. But what if I know in future I'm going
[15:07] to face a debt and upcoming debt? Can I do sleep banking? Oh, so if I've got a big thing coming up
[15:14] where I'm traveling across the world and I know I'm going to be sleep deficient, can I sleep a lot
[15:19] before it to create a what would the financial financial analogy would be? Let's say that
[15:26] we're coming up to Christmas and you're going to spend lots on, you know, presents and all sorts
[15:33] of stuff. So I know that in October and November I'm going to tighten my financial belt. So that
[15:39] when I go into the sort of Christmas period and I'm spending a lot more money, my bank account
[15:45] isn't hit as hard. I don't go into as much of a sort of a debt situation because I built up credit.
[15:52] So you can create sleep savings. Correct. It's a sleep saving system. So essentially what
[15:59] you was able to do not just put the jar to full but he was actually packing in even more
[16:10] so that you almost got this wonderful overflow of sleep. How did he know? He didn't. It was the
[16:21] experimental hypothesis. And how did they prove it? So what they did is that they walk you up to a
[16:28] period when you're going to have two or three nights of either no sleep or market sleep reduction.
[16:35] And in the week beforehand with these army cadets instead of being limited to eight hours of
[16:41] time in bed, they were able to get 10 hours of time in bed and they could sleep all that they
[16:46] want. And so they went from probably an average of about seven seven and a half hours of sleep to
[16:52] about eight and a half, almost nine hours of sleep. So they were extending their sleep duration.
[17:00] And so that they had built up this buffer, it's almost like a sort of a sleep safety net
[17:06] that's in place so that when you go into the tumble of sleep deprivation,
[17:12] you're sort of almost bolstered and you're lifted higher and therefore your degree of
[17:18] impairment that you suffer under conditions of sleep deprivation is significantly less if you
[17:23] banked sleep beforehand versus those people who were just sleeping normally and then face the
[17:29] deprivation. They went down much further in terms of their cognitive and mental performance.
[17:34] So he gave them challenges and tasks to do correct in two different groups. One group had
[17:39] sleep saving saved up from sleeping well the previous week. One group didn't. That's right. And
[17:43] they performed remarkably different. So both of them were impaired relative to a sleep rested person.
[17:49] However, the people, it's sort of how how much of a drop in your cognitive performance do you
[17:56] suffer? And what he found was that people who had built up this credit, this savings account of
[18:02] sleep in the days in the week beforehand, they suffered about 40% less of an impairment relative
[18:10] to the people who had not created any savings plan. Now they weren't in debt. They were just net
[18:17] neutral. But boy did they drop quickly. Whereas those people who'd had some
[18:24] cash in the sleep credit system, they didn't fall anywhere near as far. But this is remarkable for
[18:29] people like you were saying who are facing let's say if I've got a sprint at work or I'm a medical
[18:35] doctor, I know I'm about to go on call for the next 40 hours. You're a military aviation. All of
[18:41] the new parents, all of these circumstances are places where now we know athletes is a great example
[18:47] when we work with athletes people like Michael Granner have demonstrated that athletes sleep
[18:52] terribly typically the night before a huge performance. No math, you know, of course the nerves.
[18:58] But what you can do is you can have them bank sleep in the days before when they're not as nervous.
[19:03] And therefore their performance doesn't suffer as much even though they know they're going to be
[19:08] deprived. Sleep is so important isn't it? And I think everybody now knows that because of people
[19:13] like yourself or really, you know, you were the real pioneer in pushing this subject into
[19:16] the world. I remember when you first went on Joe Rogan's show the amount of my friends that sent
[19:20] me that episode and then sent me your book was just staggering. It was like that was the catalyst
[19:24] moment I think in society for the mainstream to really start talking and caring about sleep. However
[19:30] there's still so many people struggling because of all the factors that you talked about when
[19:36] we're talking about group two who have those lifestyle factors, the stress, the psychological
[19:39] factors, the trauma, et cetera, et cetera. What can we give them? Those people, the people that
[19:46] really, really struggle. Maybe they haven't got a disorder. We'll come to the people with sort of
[19:49] sleep disorders later and we'll talk about optimizers. But what is the new information or advice
[19:55] that we can give them that will help them once and for all? Sleep eight hours a night and get
[20:02] their life back. If you were to push me to say what are the three most impactful things that you
[20:10] can start doing tonight to start sleeping better, it would be the following digital detox.
[20:18] Okay, let me write this down. Digital detox, okay. What does that mean? One hour before bed,
[20:23] try to limit activating social media, engagement, email and text messages that are going to trigger
[20:34] you. It's fine to listen to a podcast. You heard it here folks. It's also good to like and
[20:43] subscribe, would you say? I would say that like and subscribe and then just click here so that you
[20:49] get the latest notification. You get that bell. Just click on the bell icon so that you
[20:56] so it's not a problem of blue light. A quick aside, we've been taught this myth of the blue light
[21:03] effect from devices and it really is a myth because an incredible Australian researcher,
[21:08] a guy called Michael Gradesar has almost single-handedly changed what I think of us being the zeitgeist
[21:16] for a while after a very influential paper, which is a great paper and what they showed was that
[21:20] one hour of iPad reading before bed ended up empowering your melatonin, it disrupted sleep,
[21:27] it reduced the amount of dream sleep and even after they stopped reading the iPad,
[21:31] the blast radius impact on your dream sleep lasted a week. It's almost like the drug needed to get
[21:37] washed out the system that even when you'd stop using technology for an hour before bed,
[21:42] the impact of that technology, even though you'd stop using it, could still be seen in the
[21:47] echo of sleep disruption for a week later. There was a very influential study in a very prestigious
[21:53] channel. That was probably about 10 years ago, but then Michael Gradesar, this incredible Australian
[21:58] researcher, started to say, well, I can't replicate these findings. And what he was discovering is that
[22:04] it's not the blue light, that's the problem. Now the blue light will change aspects of your melatonin
[22:09] and melatonin is a hormone. It simply tells your brain and your body when it's night time,
[22:14] when it's time to fall asleep. It doesn't participate in the generation of sleep.
[22:18] Melatonin is like the starting official at the 100 meter race. It brings all of the races to the
[22:22] line and it begins the timing of the race, but it doesn't participate in the creation of the race
[22:28] itself. That's a different set of chemicals. It doesn't make you go to sleep. It doesn't make you,
[22:32] and if you look at what we call metronalysis, where we gather together all of the individual
[22:36] studies on a topic, and we put them in a big statistical bucket, what they found is that melatonin
[22:40] will only improve the speed with which you fall asleep by about 3.4 minutes, and it will only
[22:47] increase the efficiency of your sleep by about 2.2%. So not much more than placebo.
[22:55] So melatonin is, the placebo effect is the most reliable effect in all of pharmacology.
[23:02] So, you know, maybe no harm, no foul. I would say, and don't forget, I will come back to the
[23:07] three, but when it comes to melatonin, be careful. More isn't always better. And you run the risk of
[23:15] confusing your morning brain into a dense night time fog. And what I mean by that is
[23:24] 10 milligrams or 20 milligrams of melatonin is what we call a super physiological dose,
[23:29] which again is just a fancy medical term to say, it's a size of magnitude of melatonin
[23:34] that your body wouldn't have a naturally release. It's far greater. So melatonin is the signal
[23:40] of darkness, and normally by the morning hours, our natural release of melatonin has stopped,
[23:46] and you're down to zero levels again. So you wake up, and your body no longer has the signal
[23:52] of melatonin saying it's night, it's night, it's night. But if you've dosed yourself with 10
[23:57] milligrams or 20 milligrams of melatonin, you run the risk of saying, well, yes, I know it,
[24:03] quote unquote, knocks me out. But the problem is, in the first three or four hours of the waking
[24:08] morning, you're struggling because you're in this fog of a hormonal melatonin, a hormonal
[24:15] signal saying it's still pitch black. Now, it's not. It's bright light outside, but your body is
[24:20] fooled into thinking it's pitch black because you've dosed yourself too high, and no one
[24:25] do you're reaching for two or three cups of coffee in the morning. So what dose of melatonin
[24:29] should I be taking? Somewhere between probably about 0.1 to three milligrams. And do you advise
[24:37] melatonin for people? Yes, in two conditions. The first or circumstances I should say, the first
[24:43] is when you're going through jet lag, wonderfully helpful, but timing is critical. You need to
[24:50] create that sort of that artificial signal of night, because let's say that you and I here in
[24:55] Los Angeles, we're both going to fly back to London tomorrow. And London is eight hours ahead.
[25:02] So we fly overnight, we arrive in London, and then that first night, let's say we decide to go to
[25:07] bed or I decide to go to bed in the hotel at midnight. The problem is here in Los Angeles,
[25:14] and my body clock, it's still 4 p.m. because London's eight hours ahead. So my melatonin is not
[25:20] going to rise for probably another six or seven hours. So I need to artificially hijack my melatonin
[25:27] system and tell my brain, oh no, it's not 4 p.m. It's instead, it's midnight. And so they're
[25:34] under conditions of jet lag, very helpful. The second is if you have a circadian rhythm disorder,
[25:40] let's say that you're someone who has an advanced circadian phase, what that means is you're
[25:46] someone who really can't get sleepy until three or four in the morning, and you would prefer to
[25:51] be sleeping throughout most of the day. So you're almost nocturnal. Is that genetic disorder?
[25:56] Yes, it's a genetic disorder in part. How many people have that?
[26:00] Probably one to two percent of the population have a very severe and what we call an advanced
[26:05] circadian phase disorder. But their melatonin can also be helpful because once again,
[26:10] their melatonin part of that problem is that their melatonin is very delayed.
[26:14] So they don't get the signal of, oh, it's night until maybe four o'clock in the morning.
[26:20] You and I, we start to get our signal of melatonin, depending on our chronotype, by somewhere
[26:25] between about nine, 10 or 11 p.m. They may be delayed by five hours. So if we can give them melatonin,
[26:32] we can artificially try to fool their brain into thinking it's actually earlier in their biological
[26:37] rhythm. So they sleep earlier and they're more in sync with the rest of society.
[26:42] How does someone know if they're that type of person if they have that disorder? Is there,
[26:45] there's not a way to test, is there? Well, what we typically do is we will bring you into a laboratory
[26:50] and we will measure your innate level. So we will shut out sort of all windows or clock faces have gone
[26:56] and we just let you run your natural rhythm. And they have the same rise and fall in melatonin,
[27:03] just like you and I do, except where it's doing that rise and fall of melatonin on the 24-hour
[27:09] clock face is radically different. For you and I, it's, you know, nine, 10 p.m. 11 p.m. at night when
[27:16] we're starting that melatonin crescendo. For them, it's four o'clock in the morning. So we can
[27:20] measure it. It's not in their minds. It's not their choice. It's a biological eating.
[27:25] Are you concerned that melatonin is becoming more and more popular as a way to solve
[27:32] lifestyle issues that have, of course, sleep impairment? Because I'm seeing loads of, you know,
[27:38] I'm an investor. So I see lots of companies now pitching me different products that have melatonin
[27:43] in them as a sort of day-to-day sleeping supplement. I think I'm really torn. I've been on both sides
[27:50] of this argument and I'm cautious about it for two reasons. The first is in pediatric populations
[27:56] here in the United States. Pediatric? Yeah. So the people's use of melatonin in kids is increasing.
[28:04] So in pediatric populations, it's increasing exponentially. And in fact, if you go down the sort
[28:11] of the supermarket aisles here in America, often if you go into sort of the health sort of food
[28:17] section, there's this big purple section. That's the melatonin section. And a large proportion
[28:22] of that is they're dedicated to gummies for your children with melatonin. And there was a study
[28:30] that was published about three years ago that showed here in America over the past 10 years
[28:36] there has been a 503% increase in poisonous overdose admissions to hospitals of melatonin
[28:44] in the past 10 years, 503% increase. So firstly, we've got to be a bit careful. The second
[28:51] reason is that melatonin is a bioactive hormone and it's also involved in reproductive development
[28:58] and the studies done back in the 1970s, I think, where they were looking at juvenile male rats,
[29:03] which is to say male rats who were going through adolescence. And they were dosing them with
[29:08] high amounts of melatonin. And what they found is that that stunted the development of the testicles
[29:15] and it caused testicular atrophy. Now, these were very high doses. But we've got to be a little
[29:21] bit careful. We think we say, well, melatonin is a natural hormone. So anything natural is safe.
[29:27] Melatonin overall, in terms of its safety profile, is very safe. It's actually a very good antioxidant.
[29:33] But you've got to be careful because things like, for example, testosterone supplementation in
[29:38] males. What we know is that if you're injecting testosterone, after a while, after maybe 18 months or
[29:45] so, the testicles themselves will stop producing their own testosterone. And even if you stop the
[29:52] administration of the exogenous testosterone, the injection, the testes never return their
[29:58] function of producing testosterone. Now, we don't have any evidence yet that that's the case that
[30:04] if you keep taking melatonin at high dose, your body, the fear would be, shuts down its own natural
[30:09] production of melatonin. I've seen no evidence of that. In fact, I've seen evidence that
[30:13] contrary that even after about six months or even 12 months in certain small cities, when you stop
[30:19] melatonin, the production starts again naturally. It seems fine. Problem is, people haven't been
[30:25] taking melatonin for just 12 months. They've been taking it for years. We've got no idea what
[30:31] happens after years. That was my hesitation when the first time someone offered me melatonin is,
[30:36] from doing this podcast and speaking to smart people like yourself, I've come to learn this
[30:40] principle that if you start making something for your body in terms of a hormone, if you start
[30:46] consuming something externally, like testosterone, your body will say, fine, I don't need to do
[30:51] this. It will try and return to that level of balance where the quantities in your system are
[30:55] maintained, which means it kind of learns to shut down. I always think about the case of testosterone,
[31:00] because men know that if we start injecting testosterone, then we're going to have to pretty much do
[31:03] it forever. If we want those levels to be the same. That's the worry is that there are no free
[31:08] lunches in biology, and usually if you fight biology, you typically lose. There's always a trade-off.
[31:14] Some of my friends often talk to me about these miracle things, or this thing, or take
[31:19] my daffinol, and everything will be fine. I gave up on what's the trade-off, and I get most
[31:23] consigned when they say there isn't one, because then I go, we don't know it. Yeah, you've got to be
[31:29] careful because absence of evidence is not evidence of absence. Be very careful when you're doing
[31:37] that deal with your physiology. To come back to the three things, the first thing we were mentioning
[31:44] is digital detox, and don't worry about the blue light. Worry about light in general, I'll come
[31:50] on to that because that's the second, but Michael Grades are, as I was saying, what he found is that
[31:54] the blue light doesn't really disrupt your sleep. It's a combination of first, these devices that we
[32:00] use are attention capture devices, and they are designed to fleece you of your attention economy,
[32:07] and they do it ruthlessly well. They've spent tens of millions of dollars designing these products
[32:13] to do that. What happens is that these devices become hugely activating, and as a result, they
[32:20] essentially will be a mute button on your sleepiness, so you could be there, you get into bed at 11 pm,
[32:26] you think, I am so tired, I was falling asleep on the couch watching television, and then you get
[32:31] this bed, you start going on to social media, and then you start doom scrolling, and then you get
[32:35] into this what we call bed rotting, where you just sit there, and now you look at the clock,
[32:40] and it's no longer 11 pm, it's 1 am, and you've just done sleep procrastination. Now,
[32:45] it turns out that it's yes that, that these are attention grabbing devices that will mute your
[32:51] sleepiness, but you have to be of a certain personality type, he found, not all of us are vulnerable
[32:57] to this sleep disruption of devices. You have to be someone who is perhaps neurotic, someone who
[33:03] has high impulsivity, or someone who is perhaps high anxious. If you are of any of those kinds,
[33:10] you should be really careful about your use of technology in the bedroom. Now, for me to sit here
[33:16] and say, look, put your phone in the car, in the garage, and that way, that's what I would love,
[33:23] because what we've learned to do in this modern era is the first thing when you wake up,
[33:29] what is it that you do? No, no comment. It's just you and I.
[33:39] My groundway phone before my eyes are even open. And what happens is this sort of small
[33:44] tsunami of anxiety washes over you, because as soon as you unlock the phone, it's everyone else's
[33:49] agenda for your day, but your own. And it's a terrible way to wake up. Have you ever had the
[33:54] experience where you've got to wake up for an early morning flight, and it's a critical flight?
[33:59] You know that that night is not going to be a good night of sleep. It's going to be a shallow
[34:03] kind of sleep. It's what we call anticipatory anxiety. You are anticipating an anxious event
[34:10] in the morning. And studies have shown that when we create this anticipatory anxiety,
[34:16] the amount of deep sleep that you have drops significantly. You don't sleep as well.
[34:22] And therefore, if we just do this little sort of version, this L-I-T-E version of the
[34:28] morning flight, which is we know that when we go to bed and we put our phone down,
[34:32] we know that when we wake up every morning, we're just going to open it up to that
[34:36] hit of anxiety every morning. No wonder our sleep can start to get shallow.
[34:42] Now, I'm not going to sit here and say, well, don't take your phone into the bedroom,
[34:47] because the genie is out of the bottle. And no matter what I say, it's not going back in any time
[34:51] soon. And a friend of mine, Michael Granda, has got this beautiful framework where he says,
[34:56] you can take your phone into your bedroom. It's fine. But you can only use your phone
[35:04] standing up. What's his name? Michael Granda. Tell him to find his own business.
[35:11] And what happens is that you're there and you think after about seven or eight minutes,
[35:15] I'm just going to have a bit of a sit down here. And as soon as that phone goes away,
[35:20] so I would say that digital detox is the first friend that will really help your sleep.
[35:26] The second is regularity. And we'll come on to regularity when we speak about what really makes
[35:32] for good sleep. If you were to only do one thing, not three things, but just one thing, go to bed
[35:39] and wake up at the same time, no matter whether it's the weekday or the weekend, regularity
[35:44] is king. Okay, so that's the third pillar. That's correct. Regularity. Okay. And then I have
[35:53] the teeth for timing. Correct. Which we'll go through these quantity, which we've talked a little
[35:58] bit about ready and quality. Correct. So when I looked at the science, for me, I created this
[36:05] framework of the four macros of good sleep. You've heard of the three macros of food,
[36:09] macronutrients, fat protein carbohydrate. To me, there are four macros of good sleep. And it's
[36:15] QQRT, QQRT. And it stands for quantity, quality, regularity, and timing. And think of it
[36:34] less like pillars, but the four legs of a chair. And if any one of these becomes unstable,
[36:39] the chair will topple over. So I'll probably start with the one that people have had me bang on
[36:45] about, which is quantity, seven to nine hours. This myth of eight hours is nonsense. It's a wonderful
[36:51] range, seven to nine hours. And what we know is that using that sweet spot of seven to nine hours,
[36:58] when you get less than that, the shorter your sleep, the shorter your life.
[37:02] Fuck. Short sleep predicts or cause mortality. Now we say that there's the minimum of seven hours
[37:09] of sleep. And some people have argued, perhaps correctly, that, look, if you look at these mortality
[37:14] curves, there's not much of a percentage difference between sleeping six hours versus the seven that
[37:19] you're telling me is minimum. So six hours is just fine. So all of this nonsense and rhetoric
[37:25] is silly from you. And I think they've made a conflation because seven hours is the minimum
[37:35] amount of sleep that you need to survive. Because the way that we quantify what minimum is,
[37:41] is based on whether you die or you don't prematurely. The amount of sleep that you need to survive
[37:50] is different than the amount of sleep that you need to thrive. And people will conflate the
[37:56] former with the latter. So you've got to be careful when people are sort of touting on social
[38:00] media saying, well, no, but look, there's not much difference between my sort of survival rate
[38:04] on six hours versus seven hours. You may have just as much of a long life, but the quality of your
[38:10] life will be very different. So that's quantity seven to nine hours. And is that, does it change for
[38:16] parents, by the way, because I've met somebody parents that seem to be functioning better than me,
[38:21] and they've got four, they're having like four or five hours sleep. Did evolution not give parents
[38:24] any leeway or anything when they have kids that suddenly their brain changes and now they can
[38:29] survive with less sleep? The evidence doesn't suggest that once you go through parenthood, you get
[38:34] some magic sort of, you know, immunity shot that makes you, you know, resilient and not vulnerable
[38:42] to a lack of sleep. And in some ways, you could argue because we used to, you know, live as a collective
[38:48] tribe, and we would share duties. At that point, you know, Mother Nature doesn't really worry too much
[38:55] about you now, because you've already procreated and you've passed on your genetic code. So you are now
[39:03] the sort of, you know, the not particularly well, you know, cared for individual through evolution,
[39:10] it's your offspring that gets. So it sacrifices you in a way. I mean, that's what we see in the animal
[39:15] kingdom. Did you see that documentary about the octopus? Yeah, it's just, I mean, I thought it's
[39:21] beautiful documentary, but the TLDR for anyone that hasn't seen it is once the octopus, and I'm going
[39:25] to completely butcher this, so please ignore, once the octopus has given birth, it dies, basically,
[39:32] doesn't move out of that hole and it dies. Is that rough? Well, I don't know if it dies, but it's
[39:38] level of an active life. I searched, does the octopus die after reproduction? And it says yes,
[39:44] female octopuses die after their eggs hatch. After laying eggs, a female stops eating and devotes
[39:50] all of her energy to protecting and oxygenating them until they hatch. Once they do, she dies
[39:56] shortly after. A process called semi-low parity, meaning they reproduce only once. This death is
[40:04] triggered by hormone changes from the optic gland, similar to mammalian prochurchary glands,
[40:10] and males die shortly after mating as well, usually within a few months. That is wild.
[40:18] In some ways, it's tragic and it reminds me, I'm so glad that I'm not an octopus,
[40:23] but coming back to it. There doesn't seem to be some magic cloak of invincibility that you put on
[40:35] when you go through parenthood. Certainly, what we know is that the number of individuals who can
[40:41] survive on six hours of sleep or less and show no impairment in either their brain or their body
[40:47] rounded to a whole number and expressed as a percent of the population is zero.
[40:53] So quantity matters, but it turns out that we got it wrong in thinking that was the only thing,
[41:00] because then came quality, so QQRT. Quality is defined in sleep science as two things.
[41:08] The first is something that your sleep tracker will measure, which is the continuity of your
[41:13] sleep, meaning do you sleep in one or two nice longbouts throughout the night? That's good quality
[41:19] of sleep, nice, continuous bouts. Versus your sleep is very fragmented by all of these awakenings,
[41:25] that's very poor quality of sleep, and the way that you can measure it in your sleep tracker
[41:30] is just by looking at the app, and there'll be something called sleep efficiency.
[41:34] Sleep efficiency is defined as the following of the time that you're in bed, what percent of that
[41:39] time is spent asleep. And what we like to see is you north of 85% or above, so this is kind of like
[41:46] the user's guide to sleep trackers. What I want to see is 85% or more, if you're less than that,
[41:52] we need to have a conversation. That's number one good quality of sleep. The second, which is
[41:58] sort of what these trackers can't really do, but I can do in the sleep laboratory when you look
[42:02] like a spaghetti monster because I put electrodes all over your head, I can measure the quality of your
[42:07] big, deep, slow brain waves of deep non-rem sleep. And that is a second measure, the power of those
[42:14] big, slow brain waves, that's a second measure. And quality seems to be as predictive as quantity
[42:22] in making a difference, not just to your all cause mortality, but quality even more than quantity
[42:29] when it comes to mental health has been showing the bigger signal. So again, it's not that
[42:36] quantity doesn't matter. You do have to get sufficient amounts of sleep, but quality as much
[42:41] as quantity should be paid attention to. And I haven't said that enough. The next is where we came
[42:48] to in our sort of three things that I was saying. The first is digitally talks. Then the next thing I
[42:52] said is regularity. This is somewhere where I've also changed my mind on. I've doubled down on
[42:59] regularity. There was a study that also came out of that same data set that I described. It's called
[43:04] the UK BioBank Data. And now they didn't look at 90,000 individuals, but they looked at 60,000
[43:10] individuals. And they decided that they were going to compare and split them into quartiles. So
[43:16] the most regular, to the second most regular, to then sort of the third most regular. And then the
[43:24] final quartile was those who were the least regular. And what does regular mean in this context?
[43:28] Good question. Highly regular individuals plus or minus 15 minutes in terms of going to bed and
[43:35] waking up at the same time. In other words, a total wiggle room of 30 minutes.
[43:38] Oh, okay. So if I'm always going to bed at 9 p.m. and I do that five days in a row,
[43:41] I'm regular timing. So it's regularity in terms of when you're going to bed and waking up.
[43:48] So you're right. It's timing in a way. But I'll come on to why there is a separate T for timing
[43:53] just a second. But regularity here was, okay, plus or minus. So let's say you go to bed at 845 p.m.
[44:00] one night and then nine and then nine 10 p.m. and then you're back to 8 feet. That's beautiful tight
[44:06] timing. I like that. Whereas those people who were least regular, they were 90 to 120 minutes
[44:12] disparate. They were going to bed, let's say at 11, one night, then one a.m. the next night,
[44:18] then they were going to bed at 10 30 p.m. And then they were going to bed at 12 30. They were all
[44:23] over the map. So what they found was that those people who were most regular versus least regular,
[44:30] so they'd compared the extremes of these two, those people who were most regular had a 49%
[44:37] relative decrease in all cause mortality. So they were 49% less likely to prematurely die than
[44:44] those people who were least likely to die. They had a 39% cancer mortality risk reduction. Great.
[44:52] They had a 57% cardiometabolic disease risk reduction. So that was stunning that regularity
[45:01] was incredibly powerful as a predictive signal of your different forms of mortality.
[45:08] That wasn't the best part of the paper though. They had also measured quantity as well as
[45:13] regularity in these same individuals. So then they decided to say, well, I'm going to take
[45:18] our measure of quantity and regularity and we're going to put them both in the same statistical
[45:23] bucket and do a Coke Pepsi challenge to see which one wins out in terms of predicting all cause
[45:28] mortality. We all bet in the sleep field, at least I did, it was going to be quantity. I was wrong.
[45:35] Regularity beat out quantity in predicting all cause mortality and buy quite some margin.
[45:41] Now that doesn't mean that you can now go away and say, I'm going to start sleeping four hours,
[45:45] but incredibly consistent four hours. You need both quantity and quality, but goodness does
[45:51] regularity seem to carry a massive signal. So coming back to those three things, I would say
[45:57] digital detox, just go to bed and wake up at the same time. And the final thing is light.
[46:02] In this modern world, we are a dark deprived society. We get what I call junk light at night.
[46:10] So you've heard of junk DNA. Well, we get junk light at night. We don't need all of this light
[46:16] and it fools our brain into thinking it's still daytime outside. So no wonder as a society,
[46:22] we have some struggles with sleep at night. Now that's due to many reasons stress, too much caffeine,
[46:27] alcohol, THC, but excessive light is one of the easiest things that you can do. So for the next seven
[46:35] days, just do me this experiment. If you can, set an alarm one hour before your normal bed time.
[46:42] When that alarm goes off, turn off, and I do this myself, turn off almost all of the lights in your
[46:49] house. When you say all of the lights, do you mean the little red light on my smoke alarm? No,
[46:54] that's fine. But you know, so my wife and I one hour before bed, almost all the lights, we've got
[46:59] sort of this little set of this sort of light that goes around the television, the back of the
[47:04] television. So it kind of looks like the television's cool and illuminated. I will set that down to
[47:08] about 5% of brightness and all of the rest of the lights out. So you can kind of just still see some
[47:15] illumination. So I'm not sort of, you know, looking desperately on cool and in front of everyone,
[47:21] I'm tripping over things because it's complete black, you know, then start cooling the house
[47:25] or the room as best you can to around about 67, 68 degrees Fahrenheit or about 18 degrees Celsius.
[47:31] We can speak about temperature, but just do this experiment for the next seven days, one hour before
[47:36] bed, the alarm goes off. You switch off all of the lights and ask the following question,
[47:42] do you feel sleepier? Is it so horrific? Does it make you feel more sleepy as a result? But don't stop
[47:50] there. What you've gone and done is the first positive experiment, which is you've gone from
[47:55] the no intervention lights are on to then the matte intervention, which is now the lights are off
[48:02] for an hour before bed. Don't just ask, is my sleep better when the lights were out for an hour
[48:07] before bed? Once that seven day period has finished, go back to doing what you were doing before,
[48:13] which is keep all of the lights on and ask yourself, did my sleep get better when I did the
[48:18] intervention and did my sleep go back to being worse when I stopped because I'm trying to teach you
[48:24] by directionality in the experiment. Does that make some sense? Yeah, so you get to basically do
[48:29] an AB test. Correct. You get to see both sides of the equation with that, it's more
[48:34] positive than just one direction alone, because who knows, it could just be a placebo effect.
[48:39] So regularity coming back to it is critical. So we've spoken about QQR, quantity quality,
[48:46] regularity. On the regularity. Regularity point. Why? What's going on in our brain that's making it
[48:54] from a whole mental perspective or other that's making it important for us to sleep at the same time?
[48:59] It's a bloody great question. People don't respond to rules, they respond to reasons not rules,
[49:05] so let me try and explain the reason behind the sort of the rule. When it comes to regularity,
[49:10] we have something called a circadian rhythm that we've spoken about, and there's a clock that sits
[49:16] inside of your brain deep in the middle of the brain. So we have, it just turns out, a brain here.
[49:24] Lovely. Okay, so we've got one of these hemispheres here, and then I'm just going to take out
[49:30] what we call the sub cortical sections. So these are the areas that are below the sub cortex. So
[49:36] here is the brain. So there's the front of the brain, the back of the brain, top of the brain,
[49:39] and here's the brain stem. And it turns out that right in the middle of the brain,
[49:44] right here, there's an area called the hypothalamus. Now here, this structure here, this is the thalamus,
[49:50] this is the sensory gate of your brain. So all of your five senses sound touch taste smell,
[49:55] they all flood into this gate called the thalamus. And then the thalamus will decide whether it sends
[50:02] those sensory signals up to your cortex. And when it sends the signals up to your cortex,
[50:07] you start processing them and you become consciously aware of the external world. Now as we're
[50:12] falling asleep, just as an aside, what's interesting is that this gate, the sensory gate, the thalamus,
[50:18] once we start to fall asleep, the gate will close shut. Now your eyes are technically still seeing,
[50:25] your ears are still hearing, your tongue is still tasting. But because the gate of the thalamus,
[50:31] the sensory gate closes shut, those signals that are coming into your brain are no longer sent
[50:37] up to your cortex. So you stop perceiving the outside world, which is just simply a different way
[50:42] of saying you've fallen asleep. Now the hypothalamus, you've heard of hypothermia, that means lower.
[50:53] So here's the thalamus. This area here is called the hypothalamus. And it's a tiny structure,
[50:59] but within that structure contains a nucleus. And that group of cells, the nucleus, has a fancy term
[51:06] and it's called the super chiasmatic nucleus. But the super chiasmatic nucleus is your master 24-hour
[51:12] clock. Every cell in your body has a clock inside of it. But this is the master clock. It's like
[51:21] Lord of the Rings, there's one ring to rule them all. Well, there's one clock to rule them all.
[51:26] And here in the super chiasmatic nucleus, you get the 24-hour rhythm of being awake and being
[51:33] asleep, being awake and being asleep. How does your brain keep quartz-like precision 24-hour
[51:40] clock time? How does it do that? The way it does that is that it uses signals such as light and
[51:48] dark from your eyes from your eye. And so when light comes through the retina, it tells the hypothalamus
[51:56] it's daytime. And therefore you should be awake. And its rhythm starts, it's awesome sort of
[52:01] upswing. And temperature can do this and feeding can do this also to different things. But for the
[52:06] most part, light is the principal governor that essentially acts like electrical, I should say,
[52:12] photon fingers that pops the wristwatch dial out and resets it precisely for 24 hours every single day.
[52:19] Because if you're left in the dark with no signals of light, your clock isn't precise. It
[52:25] drifts to about 24 hours and 15 minutes. So you start going forward a little bit every single day
[52:30] if you go into a cave and people have done this experiment. The thing that keeps it precise is light.
[52:35] So you need light to keep a beautiful 24-hour rhythm. But one of those things that's under the
[52:42] control of your 24-hour rhythm is your sleep, wake, cycle. What if I'm doing exercise? Exercise is a
[52:48] wonderful entrainer of your circadian rhythm as long as you're doing it at the right time.
[52:54] So if you're starting to exercise at three or four in the morning, that's not good because that's
[52:59] an activity signal that's going to confuse the brain into thinking it's the active period which is
[53:05] normally because we're a diurnal species the day. And it's the same thing coming back to my point
[53:10] of regularity using light as the best way to help with that regularity because light
[53:18] if it's artificial at night falls your brain into thinking that it's daytime still outside.
[53:24] I mean, is there any such thing as non-artificial light? I mean, I guess with the sun, but I mean,
[53:28] is there a type of light that I could use at night like candles or something? Or yes, below 30
[53:34] luxe is not going to necessarily do you a disservice. Probably below 50 luxe. Now luxe
[53:40] LUX is just a measure of light intensity and you can download on the app store a free luxe meter.
[53:46] And if you're an idiot nerd like me, you're going all over the house at night and you're sort of
[53:51] putting it in different looking and you're seeing if any kind of white spots here were, you know,
[53:55] the luxe is too high, but you need to drop that that luxe. By the way, it's a great way if people
[54:01] want to say look, my REM sleep is deficient. How can I get more REM sleep? There's a great study
[54:06] where they did something similar to what I'm telling you now. 90 minutes before bed,
[54:11] they turned down the lights to below 30 luxe and they pulled out all of the blue light.
[54:18] And just that trick of dropping the lights down, 90 minutes before bed, below 30 luxe,
[54:24] making it warm yellow light, increased their REM sleep by 18%. Wow. It's a huge margin. No need
[54:31] pharmacology. But to your question, why is regularity important? Well, I told you that
[54:38] light is one of the signals that can create regularity. It turns out that your behavior
[54:45] is another thing that will tell your brain. So meaning when you go to bed and wake up at the same
[54:51] time, it acts like an anchor. It anchors your circadian rhythm and it tells you
[54:59] almost like a scene in a movie. This scene is now complete. A new scene starts. This scene is
[55:05] complete and you've seen starts. So every time that you're going to bed at the same time and
[55:09] waking up at the same time, you are feeding the super chiasmatic nucleus, the master 24-hour
[55:14] clock in your brain. You're feeding it signals of regularity. And when it feeds on signals of
[55:21] regularity, it improves the quantity and the quality of your sleep. Your circadian rhythm likes
[55:30] consistency. It likes regular signals. When you feed it signals of light, of activity,
[55:36] of waking up, going to bed, you improve the quantity and the quality of your sleep.
[55:41] That's the reason behind the underlying rule. So having a TV in your bedroom is a terrible idea
[55:46] then, because if on that behavioral point, if I'm getting in bed, but then I'm staying up for
[55:51] three hours watching Netflix, my brain is going to be quite confused about like the behavioral
[55:56] pattern of what I'm doing in my life. It's not going to associate the bed with sleep. It's going
[56:00] to associate the bed with movies. That's one of the problems that we call conditioned
[56:05] arousal, which sounds a lot more salacious than it actually is. It's a term that we use in
[56:11] sleep medicine, which may explain insomnia. So with insomnia, let's say that the first time you
[56:18] go to this thing called a dentist and you get in the chair and it's kind of cool, you're reclined
[56:22] back and you know, you think this is fine. But then after about 14 or 15 visits,
[56:28] when you get into that chair, you are no longer looking forward to getting into that chair.
[56:33] Why? Because you've learned the association that being in that chair typically leads to a bad
[56:39] outcome. Now, the same thing is true with the bed. If you start associating the bed with anything
[56:47] other than sleep, and we give you a pass in terms of sex, but sleep and sex, anything other than
[56:53] that, you start to learn that this thing called my bed is this place where I'm awake, where I work,
[57:00] where I eat, where we have conversations, where I watch television. And so, you know, if I were to,
[57:06] and again, I'm stealing my grandmother's point, but if I were to say to you, bed sleep, bed sleep,
[57:11] bed sleep, bed sleep, bed sleep. Okay. If I were to say bed scroll, bed eat, bed work, bed sleep,
[57:20] bed TV, bed, you're confused. Because there's no predictive signal. You've never bound an association.
[57:29] Now, the way this works to your disadvantage in insomnia is the following. The insomnia event
[57:37] that begins the insomnia is typically not the thing that maintains the insomnia. So let's say that
[57:42] I had experienced a really difficult bereavement, and that triggered a form of insomnia,
[57:49] where I couldn't sleep because of the bereavement. Gradually, the bereavement is not the thing that's
[57:56] going to maintain my insomnia. It's because every time I have been going to bed over the past month,
[58:03] I have not been sleeping. I've been wide awake in my bed. So now, because your brain is such an
[58:09] incredibly associative device, it learns the association that my bed is the place where I'm always
[58:14] awake. And what do we then do? We need to break that association in insomnia. So what we do is we say
[58:21] the 20 minute rule, if you've been in bed for about 20 minutes, and it's just not happening for you,
[58:25] don't worry. Don't listen to idiots like me that doom and gloom and disease and sickness and
[58:30] one bad night is not going to be a problem. It's just not. So just say, look, tonight is not my night.
[58:35] I am not, however, going to lie in bed awake because very quickly, my brain starts to learn
[58:42] the association that my bed is the place where I'm wide awake. I need to break that association.
[58:46] So go to a different room in dim light, just read a book, listen to a podcast, whatever it is,
[58:52] and the rule of thumb is the following only return to bed when you are sleepy.
[58:57] And so there's no time limit. And that way you gradually re-learn the association that my bed
[59:02] is the place where I always get consistent sleep because otherwise it's the dentist's chair,
[59:07] you walk into your bedroom and you look at your bed and it's your nemesis and you convince yourself
[59:13] even before you get into bed, I'm not going to sleep because that's the place where I always don't
[59:18] sleep. And by the way, if you suffer from the 3M awakenings, my first question is how do you know
[59:23] it's 3AM? And that's your first problem. Looking at the clock does two things. It makes you more
[59:30] anxious. And second, because your brain is such an incredibly associative device, you start to then
[59:38] decide that 3AM is the time when I need to wake up. If you keep looking at the clock, you keep
[59:44] reinforcing that it's 3 or 4. And sleep at 3 o'clock in the morning is like trying to remember
[59:49] someone's name. The harder you try, the further you push sleep away. Sleep is something that happens
[59:55] to you. It's not something that you make happen. And so at that moment, the best advice if you don't
[1:00:02] want to get out of bed is do any one of the following, meditation, just do a guided meditation,
[1:00:09] you can download apps. Next, if that's not your thing, that's okay. Do box breathing. You can sort of
[1:00:15] inhale for five, hold for six, exhale for seven. There's all sorts of different numbers, but you
[1:00:21] can do breathing exercises. The third, if you don't like that, is a body scan. So close your eyes,
[1:00:26] start at the top of your head. Feel as, you know, do I have tension in my forehead? Do I need to
[1:00:30] relax it? What about my neck? Do I need to move through your body and gradually go down? How
[1:00:35] am I shoulder blades feeling? I just relax down into the bed and gradually down into the chest,
[1:00:40] into the move through and just relax. If none of those things feel fun, the next thing you can do
[1:00:47] is take yourself on a mental walk. There's a great study from my university, at the University of
[1:00:52] Berkeley, California. And we didn't do this study, Alison Harvey did it. By the way, counting sheep,
[1:00:58] bad idea, makes your sleep worse. It turns out, why is that? Because with every kind of little
[1:01:04] bleeding cotton wall ball with a strange look on its face that leaps over the fence that you're
[1:01:09] counting, you're reinforcing every minute of sleep that you're not getting, and it seems to make
[1:01:15] matters worse. But what she found was that there's an alternative. If you think about a walk that you
[1:01:21] know in great vivid detail, so for me, it's going to be walking the dog. So I go over to the shelf,
[1:01:26] I open the door, is it the red lead or the, I'm going to go with the blue lead today. So I clip the
[1:01:31] dog in with my right hand, I open the door with my left hand, I take a left down the stairs, I look
[1:01:34] at it's that level of, I want you 4K detail in terms of granularity. And what's common about
[1:01:42] every method I've just described, meditation, box breathing, sort of body scan, going on a mental
[1:01:49] walk, all of these things having common that you get your mind off itself. In that particular
[1:01:57] example where she asks you to vividly think about a journey that you know, what did she find in
[1:02:02] the study? What she found is that that increases the speed with which you fall back asleep significantly.
[1:02:10] Because as I said, it's so, you know, her work to me demonstrated that it is so like that name,
[1:02:17] because the moment I stop trying to remember someone's name, what happens?
[1:02:24] You remember it. I remember it. And so when you do these types of exercises where you're getting
[1:02:29] the mind off itself, the next thing that you typically remember is your alarm clock going off
[1:02:35] in the morning. Is this why people listen to very vivid sleep stories and why I listen to serial
[1:02:42] cure documentaries? Serial killer documentaries, true ground documentaries, I should say that's
[1:02:48] a bit more nice to palette. I don't know of them. My suspicion is that they may be doing your
[1:02:56] deep sleep a disservice. And stick up for me in the comments. If you listen to true crime to fall
[1:03:03] asleep, please write it below in the comments section. If you find it subjectively wonderfully
[1:03:09] pacifying and calming and there is not death, naming, blood and limbs being distributed at high
[1:03:18] velocity all over the scene, I would say it's great. But if it looks like a Quentin Tarantino movie
[1:03:23] or sounds like one, maybe harm and foul rather than just in my ears. But yes, so you know,
[1:03:31] we forget that to the best of my knowledge, the meditation company called Calm, now I have no
[1:03:37] affiliation with them. They were doing somewhat well. But what they realized is that they wanted
[1:03:42] people to sort of meditate in the morning. When they looked at their usage statistics, people
[1:03:46] were meditating in the morning. But then there was a huge swath of usage right before bed.
[1:03:51] People were self-medicating their state of insomnia. And then through a stroke of genius,
[1:03:55] they realized when we were young, we used to love falling asleep to our parents, reading those a
[1:04:01] story. Why is that any different when we become adults? So they created sleep stories. And they
[1:04:08] went from struggling as a company, I think, to becoming the first, well, one of the first
[1:04:13] billion dollar valuation health companies out there. They became a unicorn. And now they can,
[1:04:19] they've got people like Matthew McConaughey, they've got Harry Styles, and then occasionally they've
[1:04:24] got a, you know, an unfortunate British sleep scientist with a bad voice. But you can listen to
[1:04:30] these sleep stories. And they are wonderfully separate. Why? Because they get your mind off itself.
[1:04:36] We talked early on about melatonin. And there are other supplements which people talk a lot about.
[1:04:42] One of the ones that's become really popular is magnesium. I've heard Ashawaganda and I've
[1:04:47] heard magnesium a lot. Yeah. Is there any efficacy to these? Are these useful?
[1:04:51] The first thing I would say is that if you're suffering from sleep problems and you're looking to
[1:04:55] supplements, you're stepping over dollars to pick up pennies. Okay. What you need to do is think
[1:05:02] about the fundamentals, regularity, watch your caffeine intake, make sure you're not drinking too
[1:05:08] much alcohol, get regular, dimmed down half the lights, digital detox. Any one of those, but
[1:05:14] especially all of them combined, are going to get you log orders of better sleep than reaching for
[1:05:20] the latest supplement bottle of whatever it is. The second thing to say is think about it from
[1:05:27] a logical standpoint. If there were really some supplement that promises to be the Shangri-La
[1:05:33] of all resplendent sleep at night, the drug companies would have been all over it decades ago.
[1:05:40] To put it in context, it took George Lucas, I think, about 30 years to amass something
[1:05:44] like four billion in revenue from the Star Wars franchise. It took Ambien 22 months.
[1:05:51] That's how big a business sleep farmer is. Ambien is a sleep pill. Ambien is a sleep pill.
[1:05:57] Magnesium, if you dig into it, and I did a deep dive about three years ago because I kept hearing
[1:06:03] it too, this magnesium magnesium. The first thing to note is that most forms of magnesium, magnesium,
[1:06:08] oxyde or magnesium citrate, most of these forms of magnesium don't cross the blood brain barrier.
[1:06:17] And sleep is produced by your brain. So how can something that doesn't get into your brain affect
[1:06:25] a brain process number one? There is one form of magnesium that seems to have some evidence
[1:06:30] in favor of it. It's called magnesium L308. But if you look at the literature, where did this story
[1:06:36] come from? It turns out that about 30 years ago, they started looking at people who had disrupted
[1:06:41] sleep and they were to assess their blood work. And what they found is that some of those people
[1:06:46] were magnesium deficient. And when they supplemented them with magnesium and they became magnesium
[1:06:52] normative, the sleep got better. But that's very different than saying, look, you and I were
[1:06:59] currently magnesium normative. And then dosing myself with high volumes of magnesium, am I
[1:07:06] imagining that that's going to make my sleep better? The analogy would be, let's say I developed
[1:07:11] this incredible new oxygen saturation machine. And you say to me, well, but Matt, my blood oxygen
[1:07:17] saturation right now, looking at my device, tells me it's 98.6%. It doesn't matter how fancy
[1:07:24] or good my machine is, I'm not going to get you past 100%. You're already at ceiling level.
[1:07:30] And that's the problem with magnesium supplementation. If you're magnesium normative,
[1:07:35] all you're doing is creating probably expensive urine at that moment in time.
[1:07:40] Now, there may be an indirect benefit of magnesium in that it does seem to relax muscles.
[1:07:47] And when the body is in a state of relaxation, it sends a signal of relaxation back up a branch of
[1:07:53] nerves called the vagus nerve that goes up to the brain and signals to your brain. You're starting
[1:08:00] to relax down and you get a state of quiescence. And that's very helpful for sleep. So magnesium
[1:08:06] may still have an indirect benefit on sleep through its relaxation kind of policy that it instantiates
[1:08:12] in the body. But overall, magnesium is not really moving beneath if you look at the studies.
[1:08:19] Ashwagandha is different. Ashwagandha and another compound called phosphatidile
[1:08:26] serine, phosphatidile serine and Ashwagandha, both of these supplements seem to help do one of two
[1:08:34] things. They either ratchet down the fight or flight branch of your nervous system. And they
[1:08:40] can also reduce the amount of cortisol that the body is releasing. That's important because
[1:08:47] I see a lot of people coming to the sleep center where I'm at and they have what I call the
[1:08:51] tired but wired phenomenon. Where they come to me and they say, I am so tired. I am so, so tired.
[1:08:58] But I'm just so wired emotionally and from a nervous perspective that I can't fall asleep.
[1:09:03] And let's say that you've done, let's say, you know, an onstage event. And it's incredible. You've
[1:09:08] got that onstage buzz. You come off stage at 11 p.m. and normally you'll be fast asleep.
[1:09:14] But you know you are so wired. It doesn't matter. You are tired as tired as can be but you're so wired
[1:09:20] you can't fall asleep. That's the fight or flight branch being switched on. And you just can't
[1:09:25] fall asleep. You need to push it back off. Phosphatidile serine and Ashwagandha will both push you back
[1:09:30] over into the more quiescent what we call parasympathetic nervous system branch. That's good.
[1:09:37] However, they also will reduce cortisol and cortisol is a wake promoting hormone.
[1:09:43] Cortisol is fine. We get a bad rap. You need to have your cortisol start to spike a few hours
[1:09:49] before bed and it helps with the waking up process. It's wonderful. Every day we have a cortisol
[1:09:56] spike that starts happening before we wake up. It's one of the things that helps us wake up
[1:10:01] and then it builds us to this beautiful crescendo mid-morning where you should be awake and
[1:10:07] not needing caffeine. And it drops before bed. And then it starts to peak in the middle early
[1:10:14] afternoon and in fact usually peaks the late morning hours I should say. And then it will start
[1:10:18] it's awesome sort of downswing. And what you see is that right before you go to bed, cortisol should
[1:10:25] hit its lowest point what we call it's nidia. It's lowest trough. What's interesting by the way
[1:10:31] just as an aside is that in somnia we can classify it usually as at least one of two different types.
[1:10:38] There's actually multiple but let's just say there are of those multiple. There are two types.
[1:10:43] One is called sleep onset in somnia. I can't fall asleep. The other is sleep maintenance in somnia.
[1:10:48] I can't stay asleep. When they've looked at people's cortisol on a 30 minute by 30 minute
[1:10:55] basis on the 24 hour clock face we go through just what we described. Just before we wake up we get
[1:11:00] this rising cortisol. It peaks late morning and then it drops down and right before bed our cortisol
[1:11:07] is almost at its lowest point. Within somnia patients they show exactly the same thing. A beautiful rise
[1:11:14] in the late morning hours it starts to come down but then you see two anomalies.
[1:11:20] Right before bed it goes back up and then in the middle of the night even when it's starting to rise
[1:11:27] it will have this abnormal spike right in the middle of the night too. And what we believe is that
[1:11:32] that may in part explain sleep onset in somnia cortisol should be coming down and it should stay
[1:11:38] low right before we go to bed but then it jumps back up and in somnia patients I can't fall asleep.
[1:11:43] And then it continues to stay low throughout the first half of the night but then it also spikes
[1:11:49] in in somnia patients I can't stay asleep. I've had so many founders speak to me and say why
[1:11:55] didn't this particular ad that I ran on this platform work for me. Maybe the copy wasn't good the
[1:12:00] creative wasn't strong but usually the problem is they're not having the right conversation
[1:12:03] because that ad never reached the right person. And if you're in B2B marketing that is much of the
[1:12:08] game and this is where linkedin ad solves that problem for you. Their targeting is ridiculously
[1:12:14] specific you can target by job title, seniority, company size, industry and even someone's skill set
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[1:12:31] ads also drive the highest B2B return on ad spend across all ad networks in my experience.
[1:12:36] If you want to give them a try head over to linkedin.com slash diary and when you spend $250
[1:12:43] on your first linkedin ads campaign you'll get an extra $250 credit from me for the next one
[1:12:49] that's linkedin.com slash diary terms and conditions apply. We were talking about
[1:12:55] regularity timing and all these things in quality and quantity but one of the things I learned from
[1:13:00] your work is that that last hour is potentially the most important hour of me being in bed.
[1:13:07] And I say this in part because my girlfriend should have about six hours, six and a half hours
[1:13:12] sleep she sleeps very very well perfect sleeper but she'd always get up really really early and
[1:13:18] in part that was because of the guilt that I talked about but I had a conversation with her
[1:13:22] about the guilt and I said just stay in bed as long as you need to stay in bed like just have
[1:13:25] that extra eight hour and in part that's because I learned that the further we go in sleep the more
[1:13:32] REM we're getting yeah okay can you explain that to me with these four blocks why that last hour
[1:13:38] is particularly important and why we shouldn't be jumping out of bed or why we should be using
[1:13:42] certain sleep devices to wake us up when we're at the end of that last hour of REM.
[1:13:46] Absolutely so here we have the four blocks of sleep so when we first fall asleep we go into light
[1:13:54] non rapid eye movement sleep stage one this is the stage of sleep that if I wake you up out of it
[1:14:00] you say I wasn't sleeping now it's just that you're just in that transitional phase this beautiful
[1:14:07] liminal state between the windows of wakefulness and true sleep so this is your bridge between the
[1:14:14] waking world and the sleep world and it doesn't last for very long maybe just 10 or 15 minutes at
[1:14:19] tops then you get into the workhorse of sleep this is stage two non REM sleep 50 percent of your
[1:14:25] night is spent in stage two non REM sleep I don't like the word light non REM sleep I've often
[1:14:32] used it but it's not really it's we do a lot of cognitive processing in stage two non REM sleep it's
[1:14:37] good stuff it's not just the stage that you have to go through from sort of you know deep non REM
[1:14:44] sleep to go back to stage two in order for you to get to REM but I'll come to that so we have fallen
[1:14:50] asleep 10 minutes yeah now we're in stage two non REM sleep we'll stay there for about 15 or 20
[1:14:56] minutes then if it's in the first couple of hours of the night we go down into the very deeper stages
[1:15:02] of deep non REM sleep this is where the brain wave patterns slow down but the brain waves become
[1:15:09] incredibly big huge big powerful slow brain waves this is where you get an enormous amount of
[1:15:16] restoration recovery of many of your major physiological systems physical recovery physical
[1:15:23] recovery but mental tune yeah it's during deep sleep that you take newly minted memories that
[1:15:29] you've learned and you hit the save button on those memories so that you don't forget deep sleep
[1:15:34] essentially is going to future proof the information that you just learned today it transfers
[1:15:41] information from a short term storage vulnerable reservoir to a more permanent long term storage
[1:15:47] site it's during deep non REM sleep when we have this communication so think of those deep
[1:15:53] powerful slow brain waves like long wave radio station when you used to tune into a radio station
[1:15:58] the car you get huge ability for information transfer across long distances across huge paths
[1:16:05] in the brain it's amazing so we've gone from light non REM then we go down into deep non REM
[1:16:11] we'll stay there for about 15 or 20 minutes then we'll start to rise back up again we'll go back
[1:16:17] into stage two non REM sleep wait we've gone from one two three to two yes so we've gone think about
[1:16:23] it more almost like a roller coaster ride so we go from light non REM and then we go down
[1:16:31] into stage two non REM then we go down into deep sleep and then we're going to rise back up into
[1:16:37] light stage two non REM sleep we're going to stay there and after about 70 80 minutes you're going
[1:16:44] to pop up and you'll have a short REM sleep period oh okay like this and this is beautiful so this
[1:16:50] is what we call a hypnogram I'll put this on the screen for anyone lovely so what I'm describing
[1:16:56] here is this roller coaster ride so we fall in sleep light stage one non REM go down into stage two
[1:17:02] then you go down and you have a heavy period of deep non REM slow wave sleep stage three
[1:17:08] and then and that's what you see on your sleep tracker is deep sleep this is light sleep this is
[1:17:13] deep sleep stage two non REM sleep light sleep stage three non REM sleep deep sleep but then
[1:17:19] you'll start to climb back up and then you may pop up and you'll have a short REM sleep period
[1:17:24] here after about 70 or 80 minutes so you'll have about 10 minutes of REM sleep and then back down
[1:17:29] you go again you go down into non REM sleep and then up into REM down into non REM sleep and you'll
[1:17:36] go up into REM down into non REM sleep and up into REM so what's interesting however is that the
[1:17:42] ratio of non REM to REM changes now there's a myth out there and it's a bit of a problem
[1:17:50] we humans have a 90 minute average non REM to REM cycle so we go down into non REM sleep
[1:17:57] and then up into REM sleep every 90 minutes then we go back down into non REM sleep and then
[1:18:01] up into REM sleep so we go down into non REM sleep and then up into REM in this 90 minute cycle
[1:18:07] the problem is that it's on average 90 minutes it ranges from 70 minutes to 120 minutes from
[1:18:15] one individual to the next so you know these devices that you may have seen tried to sort of
[1:18:20] you know entrepreneurship they say I'm going to wake you up at the ideal moment in your 90 minute
[1:18:27] cycle so that this thing that sits on my bedside I tap it when I'm the lights go out and then it's
[1:18:32] going to go on it's 90 minute cycle it's going to figure out the perfect moment to wake you up
[1:18:36] it's nonsense because my sleep cycle may be 75 minutes yours may be 105 minutes it's got
[1:18:42] no idea because it's using a hard coded 90 minute cycle it's it's in some ways nonsense
[1:18:48] but we go down into non REM sleep and up into REM sleep every 90 minutes what changes however
[1:18:54] is the ratio of non REM to REM within those 90 minute cycles as you move across the night
[1:19:01] such that in the first half of the night the majority of those 90 minute cycles are comprised
[1:19:06] of lots of deep non REM sleep and very little REM sleep but as you push through to the second half
[1:19:12] of the night now that seesaw balance shifts over and you spend much more of your time in REM sleep
[1:19:19] in the second half of the night and particularly just as you said in the last two hours of the night
[1:19:24] why is this consequential well just as you said and you spoke about for your girlfriend let's say
[1:19:29] that you know I normally go to bed for argument's sake and I'm not saying this is the ideal time
[1:19:33] but I go to bed at midnight to make the math easy and I wake up at 8 but tomorrow I've got to catch
[1:19:38] my flight back home so I'm going to wake up two hours early so I'm going to wake up six rather than
[1:19:43] eight I've lost two hours of sleep so how much total sleep if I lost well I've lost 25% of my total
[1:19:49] sleep two hours of my eight hours 25% well yes and no I've lost 25% of my total sleep but I may
[1:19:58] have lost 50 60 70% of all of my REM sleep why because REM sleep comes in the second half and
[1:20:05] then particularly those last couple of hours of sleep so that's why it's not just academic that you
[1:20:09] understand the sleep cycle relationship but it's also pragmatic because it can impact the amount
[1:20:15] in fact the easiest way if people said how can I get more REM sleep I would say just sleep 15
[1:20:21] minutes later into the day than you normally would do and you will disproportionately bias yourself
[1:20:27] towards getting significantly more REM sleep and why does REM sleep matter?
[1:20:32] REM sleep is a brain state firstly that is incredibly active in some in fact some parts of the brain
[1:20:38] particularly if I were to show you these deep emotional centers of the brain as I call this brain
[1:20:43] apart so we've got these sort of deep emotional centers in the brain that sit and in fact the sort
[1:20:51] of the more just underneath in here tucked in inside just next to your brain stem at the top of it
[1:20:57] and these emotional centers are called the amygdala and you have one on the left and one on the
[1:21:02] right side of your brain that part of the brain together with a memory structure that runs alongside
[1:21:07] it called the hippocampus those two parts of the brain form what we call the limbic system and
[1:21:12] you may have heard of the limbic system the emotional centers of the brain those can be up to 40%
[1:21:17] more active when you're in dream sleep than when you're awake dream sleep dream sleep is rapid
[1:21:22] eye movement sleep REM sleep so REM sleep is the state now it depends on how you define dreaming
[1:21:28] if you define dreaming as any mental activity reported upon awakening then you dream in all
[1:21:33] stages of sleep like non-rem sleep deep REM sleep so what would what would that sound like well
[1:21:37] if I woke you up and said Stephen just tell me what was going through your head and you said well
[1:21:41] I was just thinking about the next time you're going to come in and wake me up that's just a dream
[1:21:45] thought what the most people think of dreams as the dreams that we have from REM sleep from
[1:21:52] rapid eye movement sleep that's why we call it dream sleep dreams from rapid eye movement sleep
[1:21:57] are florid the narrative in fact last night when you fell asleep and you went into dream sleep you
[1:22:03] became incredibly psychotic excuse me now before you reject my diagnosis of your nighttime psychosis
[1:22:12] let me give you five good reasons when you went into dreams sleep last night you started to see
[1:22:17] things which were not there so you were hallucinating second you believed things that couldn't possibly
[1:22:22] be true so you were delusional third you became confused about time place in person so in psychiatry
[1:22:30] we call that being disorientated fourth you had wildly fluctuating emotions something that we
[1:22:37] call being emotionally labial you're all over the place and then how wonderful you and I because
[1:22:43] I include myself now as being psychotic you and I we both woke up this morning and we forgot
[1:22:48] most if not all of that dream experience so we're suffering from amnesia if you were to experience
[1:22:53] any one of those five symptoms whilst you're awake you'll be seeking some degree of psychological
[1:22:58] help but for reasons that we're only now understanding it seems to be a normal biological and
[1:23:03] psychological process so what are the reasons why do we dream we dream for at least two different
[1:23:09] reasons the first reason is emotional first aid REM sleep is what I've defined as overnight therapy
[1:23:18] and it's during dream sleep where your brain takes difficult painful emotional experiences
[1:23:24] and it acts like a nocturnal soothing balm and it just takes the sharp edges off those
[1:23:29] difficult painful experiences so that you come back the next day and you have a memory of
[1:23:35] an emotional event but it's no longer emotionally you don't have that same visceral regurgitation
[1:23:41] of that same emotional charge why is REM sleep able to do this overnight therapy this deep
[1:23:49] potentiation why is REM sleep able to sort of strip the bitter emotional rind from the informational
[1:23:55] orange as it were the reason is the following dream sleep REM sleep is the only time during the
[1:24:03] 24 hour period where the brain shuts off a stress related neurochemical called noradrenaline
[1:24:10] now you've heard of the cystic chemical downstairs in your body called adrenaline or upstairs in
[1:24:15] the brain we don't have adrenaline we have noradrenaline REM sleep is the only time where it's
[1:24:20] completely shut off and what we put forward is a theory called overnight therapy where your brain
[1:24:27] has as I told you these emotional centers and these memory centers the emotional centers the amygdala
[1:24:32] the memory centers the hippocampus you reactivate those structures when you go into dream sleep
[1:24:38] so your brain gets the chance to reactivate and replay and reprocess emotional experiences
[1:24:43] however it's doing it in a quote unquote safe neurochemical environment because that stress
[1:24:50] chemical of noradrenaline is completely shut off so it's the ideal neurochemical therapy
[1:24:57] for stripping the emotion from the memory and we put forward a theory that perhaps the quintessential
[1:25:02] disorder where this fails is PTSD because when you speak to those patients not only do we see
[1:25:09] that their REM sleep is disrupted when you speak to those patients they will say look I just can't
[1:25:15] quote unquote get over the event what they mean by that is the war veteran who is now going to the
[1:25:23] supermarket and they come outside and they're in the car park and the car back fires and they
[1:25:28] instantly have the flashback to the the sort of detonation on the military field and what's
[1:25:34] happening there is that the brain has not stripped the emotion from the memory so every time they
[1:25:40] relive the memory they regurgitate that same emotional reaction so no wonder we proposed that
[1:25:47] the brain then comes back the following night and says look I'm sorry sleep I've still got this
[1:25:53] trauma memory can you do your trick of stripping the emotion from the memory and it fails again
[1:25:58] so in the next night it comes back and says I'm sorry to bother you but I've still got this
[1:26:02] emotionally charged memory please do your trick of stripping the emotion from memory it fails
[1:26:07] again this sounds like the broken record of repetitive nightmares that we see in PTSD
[1:26:14] why could this be happening levels of noradrenaline in the brain in patients with PTSD are too high
[1:26:22] and I was at a conference some years ago where I was presenting this theory we just presented this
[1:26:26] theory it was a theory it was in search of data and it turns out at the same conference it was one
[1:26:31] of those incredible moments you get hairs on the back of your neck there was a psychiatrist from
[1:26:36] Puget Sound which is just outside of Seattle on the west coast of America and he had been
[1:26:41] treating his war veterans in the Veterans Administration with a blood pressure medication called
[1:26:47] Prasasin now it turns out that Prasasin it's a generic drug because it's the Veterans Administration
[1:26:53] so it's cheap and it crosses the blood brain barrier when Prasasin gets into the brain one of the
[1:26:59] things that it does is shut down levels of noradrenaline why was this interesting what he was
[1:27:05] perplexed by is that he was saying I'm giving this blood pressure medication to my war veterans
[1:27:10] with PTSD it's not helping too much with their blood pressure but they're all coming back saying
[1:27:15] all of those repetitive nightmares they're starting to go away and I'm sleeping better and I'm
[1:27:20] feeling better what he had done was inadvertently treated their high levels of noradrenaline
[1:27:28] which were preventing the brain from kind of stopping those levels of noradrenaline down and
[1:27:33] processing the emotion from the memory it was too high in those PTSD PTSD patients but by treating
[1:27:39] them with this drug he'd inadvertently brought the levels of noradrenaline down during REM sleep
[1:27:45] and then it ultimately became one of the only prescribed medications in the Veterans Administration
[1:27:51] for repetitive nightmares because why the brain had finally got down into a quote-unquote safe
[1:27:57] chemical state because noradrenaline was too high but he treated them with this drug so he had
[1:28:05] data that was in search of a theory I had a theory that was in search of clinical data and so I
[1:28:12] raced to him after he gave his presentation I said I think I know why you're finding what you're
[1:28:17] finding I flew him down to Berkeley we spent all day together we went out for a dinner together
[1:28:21] and I just had ultimately he went on to do clinical trials in it it's not a cure all for everyone by
[1:28:26] the way it doesn't work for everyone but and I would say that there is now a better treatment for
[1:28:32] nightmares if you're suffering from nightmares and it's called image rehearsal therapy or IRT
[1:28:40] and it works through an incredible mechanism of memory that we actually had discovered about
[1:28:45] gosh 20 years ago now called memory reconsolidation so when you learn information it would be
[1:28:53] oh let's take a word document wouldn't it be just daft if you opened up a word document you started
[1:28:58] typing in you know all of this information you hit save and then you come back tomorrow and you
[1:29:03] double click on the document and word of shit you out you can't edit the document that's a really
[1:29:08] bad information storage system it's a bad idea your human memories are just like this you form
[1:29:16] new memories then you sleep and you save them but when you come back and you reactivate that memory
[1:29:22] when you recall a memory you bring it back into this opened up states like double clicking on the
[1:29:29] memory and the memory becomes fragile and malleable once again so you can update and edit that memory
[1:29:35] and then the next night you re-save it it's called re-consolidation so the first night
[1:29:39] I save it that's consolidation then I reactivated I modified and then the next night I re-consolidated
[1:29:47] so coming back to nightmares it turns out that you can do this with trauma patients who have nightmares
[1:29:53] caused by trauma for example let's say that you got into a horrific road accident and you went
[1:29:59] through your breaks failed you went through the red light you got t-bound it was just traumatic
[1:30:04] all traumatic and what you do with the therapist because you're having these repetitive nightmares
[1:30:10] of reliving that same car crash every night you work with them and you tell them the dream
[1:30:17] you recall the dream actively out loud but then working with a therapist what you do is you modify
[1:30:23] the outcome so instead of me saying the breaks failed now in the new scenario with your therapist
[1:30:28] you say well you look down and there's a manual handbrake in the car so you realize that you
[1:30:33] can actually just gradually start applying the handbrake and you bring the car to a safe halt
[1:30:38] and you go to the side of the road and there's no accident and what you're doing is you're re-opening
[1:30:43] back up that trauma memory and you're rewriting the narrative and then you sleep and you update
[1:30:51] that memory and by recalling and rewriting the memory each and every waking day you end up
[1:30:58] dissipating the severity of your trauma nightmare every single night and it's called image rehearsal
[1:31:05] therapy for nightmares it's incredibly powerful it's probably more powerful on the presence
[1:31:10] in drug that I spoke about and I'm guessing people don't sleep and also have nightmares for a variety
[1:31:16] of reasons relating to trauma generally it's a good question perhaps which is in some ways
[1:31:21] what's the difference between a bad dream and a nightmare because all of us will have bad dreams
[1:31:28] bad dreams are usually things that happen infrequently maybe you have them once every month
[1:31:34] every couple of months yeah the definition of nightmare disorder is that you have to have these
[1:31:39] dreams frequently maybe at least twice a week they have to wake you up out of your sleep
[1:31:46] and you have vivid recall plus it has to cause you some kind of daytime distress where you're not
[1:31:53] feeling good about the day it's causing you mental anguish and furthermore if it starts to lead
[1:32:00] to hopelessness or a sense that your life is not worth living you absolutely need to go and see
[1:32:08] someone and here's what we've discovered about nightmares short sleep duration not getting
[1:32:15] enough sleep sleeping less than six hours predicts by about 100 to 150% higher percentage chance
[1:32:23] of you having suicidal thoughts attempting suicide or tragically suicide completion that's
[1:32:30] bad sleep it turns out that nightmares so if short sleep has 150% higher likelihood of suicide
[1:32:40] ality having nightmares has an 800% higher likelihood of suicidal tendencies associated with it
[1:32:50] now we don't think that nightmares are causing suicidal tendencies that's not what we believe
[1:32:57] we believe however nightmares much more than disrupted sleep nightmares seem to be the canary
[1:33:03] in the coal mine nightmares are this distress beacon that leaks from our electrical static of
[1:33:10] sleep at night and it is incredibly sensitive to your suicidal tendencies your suicidal attempts
[1:33:18] and as I said suicide completion as well nightmares are a biomarker if you are having
[1:33:24] distressing nightmares that are waking you up you need to go and speak to someone about it
[1:33:30] it's absolutely paramount because there are good effective ways that you can dissipate those
[1:33:34] nightmares I'm trying to understand whether it's a malfunction or it's a signal I guess it might
[1:33:40] be both it's a very good question which is is it adaptive or is it mal adaptive is it a good thing
[1:33:49] to have a nightmare or is it a bad thing to have a nightmare we don't quite have the answer to that
[1:33:54] but let me come back to I told you there were two functions of dream sleep and we're still in the
[1:33:59] first one which is emotional first aid and it turns out that your thinking is incredibly astute
[1:34:06] we believe that at least normative dreams not nightmares nightmares may be the system failing
[1:34:12] just as I spoke about in PTSD with repetitive nightmares and in fact repetitive nightmares are
[1:34:17] so consistent in PTSD that you can't receive a diagnosis of PTSD without having repetitive nightmares
[1:34:23] that's how sort of diagnostic they are but dreaming normative dreaming even if the bad dreams
[1:34:30] is beneficial how could I make that claim there was a study done by a late sleep scientist a
[1:34:35] woman called Rosalind Cartwright and she was studying people who had gone through a difficult period
[1:34:41] let's say bereavement or very bitter divorce and they had become depressed because of that experience
[1:34:47] and around the time of the experience she was seeing them as a therapist and she was having
[1:34:52] them do dream recall so she was having them create dream diaries every single night
[1:34:58] and then she tracked these patients for a year and it turned out that roughly half of them by 12
[1:35:04] months later had remitted from their depression they got better they'd got past their depression
[1:35:09] the other half was still depressed so then she took that data and she went back with those two
[1:35:16] groups and she said is there anything different about their dreams and it turned out that there was
[1:35:22] both of those groups of people whether they could free of their depression or they stayed in their
[1:35:27] depression both of them were dreaming at the time both of them were having REM sleep both of them
[1:35:31] were dreaming what was the difference then those individuals that went on to gain remission
[1:35:38] to their depression and get better those people were dreaming of the events itself at the time
[1:35:45] that they were happening whereas those other people who didn't go on to gain clinical remission
[1:35:49] they were dreaming they just weren't dreaming of the experience is itself in other words
[1:35:55] it's not just sufficient to have REM sleep it's not just sufficient to have REM sleep and be dreaming
[1:36:02] you need to be dreaming of the difficult painful experience that you're going through
[1:36:06] to gain that clinical resolution damn so if I something going on in my life I need to think about it
[1:36:11] before I go to bed yes and no what you have to realize is that it's taken us
[1:36:20] depending on who you believe 3.4 million years of evolution to develop this thing called
[1:36:25] hominid sleep and dreaming and REM sleep I think that that evolutionary millions of years
[1:36:33] probably understands what the correct blueprint playlist of dream experience is and should be for
[1:36:41] me at night and therefore I don't need to worry about it I shouldn't try to force anything
[1:36:46] that's the first function of dream sleep is that it's emotional first aid and we've got good
[1:36:52] data for that but there's a second completely independent benefit of dreaming dreaming is a form
[1:36:59] of informational alchemy dreaming is creativity now I told you that during deep non-rem sleep we take
[1:37:08] new memories that we've learned and we fixate them like amber sort of setting a fossil in and we do
[1:37:14] that during deep sleep that saves the individual pieces of the new stuff then comes along REM sleep
[1:37:20] which happens after deep sleep and the second phase of memory processing happens that's where REM sleep
[1:37:27] starts to fuse all of the things that you've recently been learning with this entire back catalog of
[1:37:32] information and so you wake up with a revised mind wide web of associations that is capable of
[1:37:40] defining solutions to previously impenetrable problems so you know it's almost it has like group
[1:37:47] therapy for memories that REM sleep gathers in all of the information that you've learned during
[1:37:51] your day and everyone gets a name badge but unlike the waking logical connections that you make
[1:37:56] already REM sleep is like a Google search gone wrong that you insert let's say diary of a CEO
[1:38:04] and it takes you to page 20 this is dream sleep and it's about some field hockey game in Utah
[1:38:10] and you think hang on a second but how on earth is that well there was someone who had you know they
[1:38:17] had found a diary that had been lost you know a long time ago and the guy who had found it was a
[1:38:21] famous CEO and the town of this sort of you know Utah as he was watching so it's a distant non-arvious
[1:38:27] connection but it turns out that that's what dreaming is all about it's almost as though we go to
[1:38:33] sleep with the pieces of the jigsaw but by way of dreaming we wake up with the puzzle complete
[1:38:40] and when you start to fuse things that should should not normally go together but when they do
[1:38:46] every now and again cause a marked advance in evolutionary fitness that is the biological basis
[1:38:52] of creativity it's the reason that no one has ever told you look Stephen you should stay awake on
[1:38:58] a problem they don't they tell you to sleep on a problem and in every language that I've been
[1:39:04] quite about to date from you know from French to Swahili that term sleeping on a problem or
[1:39:12] something like it exists my point being is the benefit the creative benefit of sleep transcends
[1:39:19] cultural boundaries it's a common experience of homo sapiens there is an invisible tax on sales
[1:39:25] people that no one really talks about enough the mental load of remembering everything like meeting
[1:39:30] notes timelines and everything in between until we started using our sponsors product called pipe
[1:39:35] drive one of the best CRM tools for small and medium-sized business owners the idea here was that
[1:39:40] it might alleviate some of the unnecessary cognitive overload that my team was carrying so that they
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[1:39:56] that automates the tedious repetitive and time consuming parts of the sales process and now our
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[1:40:35] they just take the first step and then the next and then they keep going they stay obsessed and
[1:40:39] they stay consistent and stand store a platform I co own and one of our sponsors is the best first
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[1:41:12] day trial at Stephen Bartlett dot Stan dot store what is the most important thing we haven't talked
[1:41:20] about as it relates to the personas of those people that are probably listening right now and for
[1:41:24] the reasons why they might have clicked you know that they're probably looking again we have the
[1:41:28] optimizers we have those that have bad sleep habits and then we have those that have real sleep
[1:41:32] disorders what is the most important thing we haven't talked about that we should have talked about
[1:41:35] for them it may be the dystopian future let's talk about the dystopian future what is a podcast if
[1:41:43] it does not contain at least in this day and age a dystopian future what is the dystopian future
[1:41:49] probably the most spectacular discovery that has happened since you and I last spoke
[1:41:54] is the discovery of what we call the genetic short sleepers these are individuals who by way
[1:42:01] of a genetic mutation can survive on as little as 6.25 hours of sleep in other words 6 hours and
[1:42:08] 15 minutes of sleep and they show zero impairment in the brain or their body they can do just fine
[1:42:17] on six hours of sleep I know where this is going and we have four genes that we've identified
[1:42:23] now the first two genes the first one identified was called the deck two gene DEC two gene the
[1:42:29] second was called the ADRB1 gene which I granted I know it sounds like the next radio hit
[1:42:34] album but it's not the next radio hit album and these genes allow these individuals to get away
[1:42:43] with an amount of sleep that normally would cause predictive disease and sickness just as we've
[1:42:48] spoken about so at this point probably some people listening are thinking I think I'm one of those
[1:42:56] people just to put it in context your the probability that you will be struck by lightning in your
[1:43:03] lifetime is 0.0064 highly unlikely the chances of you having the ADRB1 gene is 0.004 and the
[1:43:17] DBR1 gene is the short sleeper gene is one of the short sleeper genes so in other words you are
[1:43:22] statistically more likely to be struck by lightning in your lifetime then you are to have that
[1:43:27] short sleeping gene so the probability is is low by the way why is this the case why do they
[1:43:35] get away with this and we've discovered now by using sort of genetic manipulations we understand
[1:43:40] why first thing is that they have a much stronger wake drive during the day so you and I and all the
[1:43:46] rest of our mere mortals will have these kind of like oscillations in our consciousness throughout the
[1:43:51] day where we'll have dips where we feel a bit sleepy and we're dragging and then we'll kind of get
[1:43:56] they don't have that they have it's like a light switch like a dimmer switch you and I we make sort
[1:44:02] of go up to like 80% brightness when we're awake and then sometimes we'll flicker and then we'll go
[1:44:07] down and we'll have pretty solid sleep maybe sort of you know down to 20% but the lights are not
[1:44:13] quite off you know sleep is it's good but not amazing these people have an all-enough
[1:44:20] thing phenomena they are all a hundred percent bright light throughout the day and then and they
[1:44:26] can maintain 17 18 hours of wakefulness no problem and then when they sleep they sleep hard
[1:44:33] they have much more efficient sleep remember we spoke about sleep efficiency and I want to 85
[1:44:39] almost all of their time at night spent in solid stable sound sleep and the depth of their sleep
[1:44:45] they have is greater so they're awake more throughout the day they build up a stronger wakefulness
[1:44:50] drive which is called a denocene which means that when they sleep they sleep harder throughout
[1:44:55] the night which means that they can then be awake for more powerful since during the day second
[1:45:01] they don't suffer from jet lag what the what do you mean they don't suffer from jet lag
[1:45:06] because of their strength of wakefulness drive when they are circadian misaligned it's as though
[1:45:11] they haven't traveled between time zones they can just stay awake they have a strong drive for
[1:45:16] wakefulness who are these people they are these genetic short sleepers and do they pass these
[1:45:22] genes onto their children yes they do and so their children have the same they're heritable
[1:45:27] can I have well firstly let's take a step back before I get to the dystopian this tells us something
[1:45:34] above and beyond biological fascination it says there is a profound statement in evolution
[1:45:41] mother nature has figured out a way genetically to zip file sleep zip phone you can compress eight
[1:45:49] down into six you know on your computer you can get a collection of files you group them all together
[1:45:54] and then you say compress these files and you compress them and you zip them into a single file
[1:45:59] and it's dense it's packed and it takes up less amount of volume do they have the same life
[1:46:06] expectancy they seem to from everything we can tell so somewhere along the way through genetics
[1:46:14] evolution is figured out how to go from eight and compress it down to six where's the dystopia
[1:46:20] well we've all heard of CRISPR which is this genetic editing manipulation tool that
[1:46:25] a lab next door to mine at UC Berkeley discovered Jennifer Downer she won a Nobel Prize for it
[1:46:30] is there some future and I hope not is there some future where we started genetically engineer
[1:46:37] people from a need of seven to nine hours down to a need of six imagine the reduction in health
[1:46:44] curve burden cost because right now the burden of insufficient sleep is vast
[1:46:50] insufficient sleep will cost most nations about two percent of their GDP here in America it's
[1:46:56] $411 billion of cost caused by insufficient sleep in the United Kingdom it's about 40 billion
[1:47:02] dollars in Japan it's 50 billion dollars solve the sleep loss epidemic which I've been trying to
[1:47:09] do by saying you know sleep enough and you could you know cause massive financial disruption
[1:47:14] in the good way but here if you start to genetically engineer people could you reduce the burden
[1:47:22] that is caused by people currently who need seven to nine and take that burden away because they
[1:47:27] no longer need seven to nine why did you say I hope not well I hope not because I think here's
[1:47:34] the following that happens it's not that I'm against that idea I would love for the burden of
[1:47:39] disease and sickness to be reduced and people not to suffer from that and if I could find a way to
[1:47:43] do it genetically I would and you could think about people arguing well imagine the productivity
[1:47:48] benefits I made huge upside of that you know people are being more productive and they're probably
[1:47:54] spending more so from a capitalistic society it's the perfect it's the adman's dream because when
[1:47:59] you're asleep it's antithetical to a capitalistic society why because you're neither producing nor
[1:48:04] consuming that's very cynical and I don't buy into that but nevertheless so all of these things
[1:48:08] would be marked the better would they not be if we genetically engineered this way why do I fear
[1:48:13] it I know for a fact that as soon as six becomes the new eight everyone starts sleeping for
[1:48:22] and now I'm just in back into the same battle again because six is the minimum that you need and
[1:48:27] they say well if that's the minimum then I'll sleep for and when I find the next gene that allows
[1:48:31] you to get away with four hours of sleep then they say well that's great so then I can go down to
[1:48:35] two and it's a form of almost this sleep currency you know inflation that I'm always fighting a
[1:48:42] battle and at some point I'll always be on the wrong side of that battle crazy these people with
[1:48:49] this gene can thrive on four to six hours sleep without any negative effects that most of us
[1:48:56] would experience dress it's so you know what is going on there and what we're seeing is this
[1:49:03] this incredible density of sleep and this epic drive for wakefulness they are more efficient sleepers
[1:49:11] they can get done what you and I take eight hours to do they can do it in six and I guess you
[1:49:17] is there a way to easily test this like it's going to allow them yeah so if you've ever done you know
[1:49:21] I think you know all of those genetic testing kits out there where it and a lot of them will allow
[1:49:26] you to download your raw data what you need to do is download your raw raw data and then there's a
[1:49:31] company I think it's called Prometheus again I have no affiliation with them I don't know how
[1:49:35] valid they are but then you upload your raw genetic data into their model and then it will list and
[1:49:42] it will rip it apart so normally those genetic services they give you a nice PDF and it's kind of like
[1:49:47] maybe 15 pages of all of the main stuff and it's this Prometheus is kind of like the you know the
[1:49:53] old school kind of scientist nerdy they will just give you this kind of raw just kind of jenky
[1:50:00] you know 50 page report the interface is terrible but you can go in there and you can search to see
[1:50:07] you know what form of the deck two gene do I have or what form of the ADRB1 gene do I have
[1:50:14] and it will tell you are you a genetic short sleeper or are you not and you can find out
[1:50:19] I've been thinking a lot lately about about certain diet states as well and whether they have an
[1:50:24] impact on sleep we're talking about circadian rhythms there I was thinking about fasting a lot
[1:50:28] and also think me myself and jack over there are in ketosis right now I wonder if you when you
[1:50:34] think about brain performance and sleep and different sort of states do you think much about fasting
[1:50:39] or yeah ketosis or yeah it's a mixed bag if you look at it certainly what you eat will change
[1:50:48] how you sleep but perhaps more powerfully is how you sleep dramatically changes how you eat and how
[1:50:56] you dispose of those calories and what happens inside of your body when you are under slept
[1:51:02] but so I have lots of cravings when I've short slept yes you have and the reason why is first the
[1:51:09] two appetite hormones called leptin and ghrelin will go in opposite directions so they sound like
[1:51:16] hobbits I know and I've got some Lord of the Rings thing here but leptin is the signal that says to
[1:51:21] your brain you're full yeah you're you're satiated don't eat anymore ghrelin is the opposite
[1:51:27] it kind of makes your stomach tummy growl and it says you're hungry you're not full you need to eat
[1:51:32] more when you are under slept leptin which says you're full stop eating that hormone is impaired
[1:51:40] drops away so you lose the I'm full signal and worse still the ghrelin signal which says I'm hungry
[1:51:47] that increases and so now you have about a 30 to 40% increased hunger drive and the final part of this
[1:51:56] is that when you are under slept and taking on board calories the way that you dispose of that energy
[1:52:02] is different your body has a higher predilection when you are sleep deprived to disposing of calories
[1:52:10] as fat rather than storing it for example as glycogen in the muscles oh so when I'm under slept
[1:52:17] um that's why you know you're more likely to get belly fat correct and what's worse is that there
[1:52:23] was a great study where they looked at people who were dieting and either getting sufficient sleep
[1:52:28] or not getting sufficient sleep what was fascinating is that both of those groups whether you are
[1:52:33] well slept or not well slept you both lost weight in fact you lost about the same amount of weight
[1:52:39] so you think okay so that's fine the problem was if you looked at what you were losing there was
[1:52:44] an issue those people who were dieting but not getting sufficient sleep 70% of all the weight that
[1:52:52] they lost came from lean muscle mass and not fat in other words when you're not getting sufficient
[1:52:59] sleep you keep what you want to lose which is fat and you lose what you want to keep which is
[1:53:08] muscle oh gosh damn it's important isn't it the sleep stuff but coming back to ketosis by the
[1:53:13] way I would say when people go into a fasted state usually what we see is that the sleep gets shorter
[1:53:21] and I'll say I sleep almost more efficiently I'll sleep for maybe just four or five hours
[1:53:27] but I feel more alert and more awake now some of that has to do with the ketosis
[1:53:33] when you are calorically deprived the brain starts to realize that something is wrong because you
[1:53:40] are lacking calories you're going into starvation so it drives on a chemical called a rexin a rexin
[1:53:47] is awake promoting chemical and it forces your brain to release much more of this wakefulness
[1:53:53] chemical called a rexin so now when you're fasting it's easier to stay awake for longer and your
[1:54:00] brain will deliberately stop you from sleeping as much it's not because it wants you to sleep less
[1:54:08] it's because the only time during our evolutionary past that we experienced short sleep was when
[1:54:15] we were in a caloric deficit and the reason came comes back again to this idea that you have to
[1:54:19] stay awake longer because you're not finding food now your brain doesn't know you've deliberately
[1:54:25] decided to fast which is a good thing in lots of ways but that's one of the reasons that when
[1:54:30] people are fasting they'll say my sleep goes to packing a hand basket you know it's really really
[1:54:36] short so when I'm in ketosis now and I'm like in on my way in and my sleep will reduce to about
[1:54:41] five five six hours my whoop scores plummet yeah until I kind of come out the other end which might
[1:54:47] take a couple of weeks and then my sleep scores seem to stabilize again but that initial transition
[1:54:52] period it looks like it's having a physiological shock it is and the shock is this chemical
[1:54:57] rexin which is this wake promoting chemical which will force you to stay awake in a very solid
[1:55:01] fashion by the way case in point people with narcolepsy this sleep disorder where they inadvertently
[1:55:08] and uncontrollably fall asleep during the day they have the opposite I just telling
[1:55:13] or I was just telling you that when you are fasting your brain dumps out this chemical
[1:55:17] rexin to force you awake in your wide awake people with narcolepsy when we've studied their brains
[1:55:23] they have a deficiency of this brain chemical erexin so they can't stay awake in a stable fashion
[1:55:30] they have the opposite of your fasting problem your wide awake because you've got too much erexin
[1:55:35] they've got too little erexin and therefore they can't sustain stable wakefulness during the day
[1:55:41] so the constantly falling asleep this story of a rexin has led to the invention of the first
[1:55:49] new class of sleeping medication that I actually favor and most people are not aware of it
[1:55:53] it's a new class of we're on to essentially web 3.0 of sleep medication web 1.0 where the
[1:56:00] benzodiazepines things like Xanax and Valium not great for sleep the second wave the web 2.0
[1:56:07] those were things like Ambion Linester Sinata both of those drugs worked in a very similar way
[1:56:14] where they go up to your cortex and they tickle a receptor called the GABA receptor GABA and it's
[1:56:22] the major neuro inhibitory transmitter of the brain so when these drugs flood your brain they just
[1:56:28] hit the red light and they stop neural firing of the cortex essentially they sedate you
[1:56:34] and sedation is not sleep but when you take an Ambion you mistake sedation for sleep it's not quite
[1:56:42] the same it's not naturalistic sleep but after we've realized by way of the story of narcolepsy
[1:56:49] that narcolepsy patients they don't have this chemical erexin and they're falling asleep
[1:56:54] inappropriately during the day well think about what insomnia is at night insomnia is almost the
[1:57:01] opposite of narcolepsy which is that narcolepsy patients they're falling asleep during the day
[1:57:08] when they want to be awake insomnia patients are awake at night when they want to be asleep
[1:57:14] so what they realize is that what we can do if this chemical erexin this wakefulness volume
[1:57:20] button in the brain is a problem in insomnia patients what if we were to just develop a drug
[1:57:27] that doesn't sedate the cortex like Ambion instead it goes down into the brainstem where the
[1:57:32] center for erexin is and these new drugs and they're called the Dora's drugs D-O-R-A small S
[1:57:41] and to class of drugs there are three FDA approved and I'll try and spell them out for you
[1:57:46] they're called Suverexant, Lomberexant and Dariderexant exactly why my synapses are filled with
[1:57:54] things like those things but there you go the three FDA approved drugs and what they do is they
[1:58:00] act like a clever set of chemical fingers they go down into the brainstem where this sort of erexin
[1:58:05] is being released and they just dial down the volume on a wakefulness and then they take a step back
[1:58:11] and they allow the antithesis of wakefulness to come in its place which is this thing called
[1:58:16] naturalistic sleep now if you look at that there's clinical data they absolutely make you sleep for
[1:58:26] not necessarily a longer period of time but you're awake a lot less so you've got nice sleep
[1:58:30] efficiency more continuity but I as a scientist could be very skeptical and I could come along and
[1:58:36] say okay so this new drug it increases your total sleep time improves your sleep efficiency
[1:58:42] but I have four words yes and so what just because I've added sleep to your night how do I know
[1:58:51] that that's functional sleep how do I know that that's useful sleep couldn't it just be like
[1:58:55] junk DNA it could be just junk sleep well they did a study where they looked at what we call the
[1:59:01] glymphatic system in your brain there's a cleansing system in your brain that kicks into high gear
[1:59:06] during deep non-rem sleep and it flushes the brain of all of the metabolic toxins two of which are
[1:59:13] things called beta amyloid and tau protein which are the culprits of Alzheimer's and that's why we
[1:59:18] note that sleep is so important because at night it's a good night sleep clean it's a power cleanse
[1:59:23] that washes away the Alzheimer's toxins so they did a study heavens knows how they got these people
[1:59:29] to participate but they brought them in they were 50 years or older and in the morning and the night
[1:59:35] before they had a lumbar spinal puncture and they siphoned off cerebral spinal fluid so they could
[1:59:42] measure how much of the metabolic detritus was in the brain before sleep and in the brain after
[1:59:48] sleep including the metabolic waste product sort of including beta amyloid and tau protein
[1:59:56] and they either had one of these drugs the doras drugs or they had a placebo and
[2:00:02] fair enough when they took this new class of medication the web 3.0 the doradrug their sleep got
[2:00:08] better but what they also found is that not only did their sleep get better but they had cleansed
[2:00:15] the brain the next morning of more beta amyloid and tau protein than the placebo group in other words
[2:00:22] it wasn't just epiphenomenal junk sleep it was beneficial sleep it was adaptive useful sleep
[2:00:29] because that drug induced sleep had washed away more of the Alzheimer's proteins and it was the
[2:00:35] first demonstration and they've now replicated it in animal models that this is a sleeping pill
[2:00:42] that isn't this advantageous which we know to be the case for things like ambient in fact ambient
[2:00:48] there's a recent study that showed that it decreases the cleansing pulsing fluid by about 30 to 40
[2:00:54] percent at night but this is a new class of medications that does the opposite and this is new
[2:00:59] and this is new the doras drugs do are as small as the problem is that a lot of insurance companies
[2:01:05] here in the United States currently do not reimburse some do and I believe that it's some of these
[2:01:12] of the three doras drugs not all of them are available in Europe or in the UK and because they're
[2:01:18] just so expensive and if you pay out a pocket it can be up to four hundred dollars a month
[2:01:24] for these medications now some in summary of patients when I go to them and say at the end of a
[2:01:28] shockingly bad month of sleep if I went to them and said look if you gave me four hundred dollars now
[2:01:33] could I I could wave a magic wand and eradicate all of that bad sleep over the previous month
[2:01:38] would you like to give me four hundred dollars most of them would say absolutely take my money
[2:01:42] but still people are being priced out at this stage but the doras drugs please look into them if
[2:01:47] you're struggling with insomnia as well as CBTI. I didn't realize there was so much new science
[2:01:53] and research that had been discovered on how to sleep well what's going on in the brain and also
[2:01:58] some of the lifestyle factors that have made sleeping so hard for so many people and with that in mind
[2:02:04] I want to do something that I've never done before which is a world first for the dorasio is I'm
[2:02:09] going to put a link below because I think this is a particular episode where if you share this
[2:02:14] conversation with some of your friends who particularly struggle with sleep or asleep optimizers
[2:02:18] or who have sleep disorders they'll get a ton of benefit from it so what I'm going to do is in the
[2:02:23] description of wherever you're listening to this podcast right now there is a link and if you click
[2:02:27] on that link and you'll see that you've got your own personalized link to share this episode and
[2:02:32] those of you that share this episode whether it's on your story on social media or in a WhatsApp
[2:02:36] group or wherever on email with your friends you will collect points for every person that listens
[2:02:42] and I will reward those and you'll see as you click on the link who have shared it the most
[2:02:47] I'm part I say this because so many of you come up to me in the street and they came up to me
[2:02:50] after I'll ask conversation and they said um that conversation you did with Matt Walker was so amazing
[2:02:55] I sent it to my aunt and she now she did this and she's changed this and blah blah blah and she's
[2:03:00] now sleeping well and then all the downstream impacts of that have been profound so I'm going to
[2:03:05] create this little system to encourage all of you to share it with someone that is struggling
[2:03:09] at the moment with sleep because I do believe I do believe that sleep is upstream from so many of
[2:03:14] the downstream symptoms that ruin our lives whether it's relationship issues whether it's libido
[2:03:19] issues or whether it's creativity issues I mean I was reading through your work and I saw your
[2:03:23] conversation with Rogan not so long ago where you talked about the fact that a sleep deprived
[2:03:29] person has their genes fundamentally working differently you talked about 700 genes working differently
[2:03:33] yeah 711 genes are distorted in their activity caused by a lack of sleep some genes that are
[2:03:39] overexpressed that are related to cardiovascular disease or stress or inflammation and other
[2:03:44] genes that are impaired which are associated with your immune system so you become immune deficient
[2:03:50] and it can be a downward compounding spiral if you're such a person that's really continually
[2:03:54] struggling with sleep and building up some of that sleep debt so that link is below check it out
[2:03:59] and we have a closing tradition on this podcast with Alaska sleeps a question for the next
[2:04:03] the question left few is what did success bring you that you never could have dreamed of
[2:04:12] it brought me two things one beneficial one lesser beneficial is that I have now the chance and
[2:04:23] gifted the chance to fly around the world and try to speak the word of sleep because the physiology
[2:04:33] of it is so silent and I used to lament why me because there are so many other much better sleep
[2:04:40] scientists in the world than me and a friend after I was saying like I don't understand why
[2:04:45] me in pasta syndrome and he just told me to shut up and accept that it's you and instead ask the
[2:04:54] question what are you going to do with it and I changed how I embrace that so I've been so fortunate
[2:04:59] that my life after publishing the book that you're holding change forever and almost all for the
[2:05:06] better and I'm so fortunate I've lived a life of such fortune by way of the sleep mission I would say
[2:05:15] though that there is also and I suspect you may experience some of this too when you raise
[2:05:24] your head above the public parapet don't be surprised if shots are fired and if you're someone who
[2:05:32] has even the vaguest hint of insecurity comments will do your lovely disservice and so I think
[2:05:45] there's a degree of kind of vulnerability and insecurity that you can develop by way of
[2:05:51] becoming someone who is in the eye of the public that had I not been in the eye of the public
[2:05:56] I probably wouldn't have been you know as self-conscious about whether it's you know
[2:06:01] your intellect or your voice or your you know disastrous you know boy band haircut whatever it is
[2:06:08] I would say that's the only slight downside overall I am the most fortunate human that I know
[2:06:15] I am so gifted by way of this thing called sleep it's a love affair that's lasted me almost 25
[2:06:20] years and I believe it's the most beguiling topic in all of science and it is treated me so well
[2:06:28] do you happy more than you could imagine at this moment in my life I am the happiest I've been
[2:06:39] why I have a a piece that I found in life for reasons that I can share or not share and go ahead
[2:06:48] and share the my life you know I found my person and and she is she appeared like lightning from
[2:06:58] a clear blue sky never saw her coming and it's interesting that I've never been able to be more
[2:07:12] myself even with myself than I have with her every day she makes me want to be a better person
[2:07:23] and I have found peace that I have never had before but you've never had before
[2:07:33] no did you have peace last time we spoke I wouldn't say I was without peace I didn't know this type of
[2:07:42] peace and I never believed in this notion of the one you know I was a scientist from a heart
[2:07:48] knows empirical kind of guy and I just did not imagine it would be such I didn't think there was
[2:07:56] such a one I would have told you if you told me that two years ago you'd give me your love story
[2:08:03] of certainty I would have thought you're misguided and that you know you just need to put down
[2:08:11] whatever substances you're using because you're delusional because there isn't such a thing
[2:08:15] she's a gift and I hope I never take her for granted I doubt it there's an incredibly sad story
[2:08:30] of a gentleman called Clive Wearing and Clive is a famous individual in the neuroscience world
[2:08:38] and Clive was the man who the movie Memento was based on which is a movie where a man has
[2:08:47] brain damage and he has profound amnesia and from that moment forward he can never
[2:08:50] make any new memories whatsoever he's dense the amnesic and he was a real life individual he
[2:08:58] contracted a virus that destroyed his memory centers and from that point forward he could no
[2:09:04] longer make any new memories and he lived in just two or three seconds of time and that spotlight
[2:09:10] of consciousness just moved forward in time he had no recollection of the past he had no anticipation
[2:09:15] of the future and the only thing the only person that he remembered and he would recognize this
[2:09:21] is wife so he could have spent this whole three hours speaking to you and then you would walk out
[2:09:26] the room for five minutes and you would walk back in and you'd say hi Clive nice to meet you and
[2:09:30] you'd say hi what's your name had no recollection the only person that he remembered was his wife
[2:09:36] but the problem was he never remembered how long it's been since he lasts or his wife
[2:09:43] and so every time that she would walk into the room after being out of it for five minutes
[2:09:48] he would jump out of his chair and he had this incredible elation and he would run and he would
[2:09:55] hug her and kiss her and I think sometimes we take our partners for granted and the only time
[2:10:02] we realize how precious they are is when they're gone and I often think about that that complacency
[2:10:10] can be one of the greatest negative forces in a relationship and I always think about Clive
[2:10:14] wearing even on the days where I'm having a bad day or I'm in a bad mood and I'm not myself or
[2:10:21] just don't want to be around someone I always try to remember his reaction and when my wife walks
[2:10:26] back in from work where I see her you know first thing I try to remember how his reaction was and
[2:10:34] how I truly feel at the time despite the blanket of negative stress trying to drown that feeling out
[2:10:42] it's a beautiful thing I think about that a lot as well in what way just the part of I'm way more
[2:10:51] cognizant now on a frequent basis almost on a weekly basis of how I'm going to feel when my time
[2:10:59] is up as it relates to my romantic relationship like I think even like mid-argument I will now think
[2:11:06] and then this actually happened like a couple of days ago wasn't really an argument we're just
[2:11:09] disagreeing about something I literally said amid a dispute that we were having I said we're
[2:11:14] going to regret this so much and what I meant was when that date when that phone call rings and
[2:11:19] someone gives me bad news that either I'm going or you're going I'm going to regret that this 30
[2:11:23] minutes was wasted doing this yeah I'm really going to regret it how much would you give to have
[2:11:28] that 30 weeks back and everything you know we're fucking arguing about I don't know some chocolate
[2:11:32] whatever it might be some trivial thing it's actually really helped me because in the midst of
[2:11:36] those storms thinking through to that moment when you get that phone call in like your ill or
[2:11:41] I'm ill and some we're not going to be around much longer it liberates you from the pettiness that
[2:11:48] a sense of immortality can create and that pettiness results in the complacency that you're describing
[2:11:54] that like I did I took you for granted yeah so it's a nice little mechanism now for me to go is
[2:12:00] this an important thing is this really important and I have to provide nuance there which is this
[2:12:05] doesn't mean don't address things correct yeah I was just about to say the conflict is critical you've
[2:12:10] got to fight well but let me mean versus you in the problem like me and you versus the problem
[2:12:15] versus me just going at you yes you have to be fighting for each other not fighting against each
[2:12:22] other yeah exactly and that you have to try to then in that context of clivewearing don't shy away
[2:12:29] from conflict if you need to have the conversation often it's like the gym if you do it well you
[2:12:36] even on the days when you kind of go into the gym you think I don't want to do this or I don't feel
[2:12:41] good you always come out feeling better than you did before and with conflict if you do it well
[2:12:48] you typically it may not be the hour after or even the day after but if you do it well you typically
[2:12:53] are better as a couple after than you were before the conflict as long as you do it well so I'm
[2:12:59] not saying don't have conflict what I'm saying is clivewearing story to me of how he loved his wife
[2:13:08] with an intent that I'd never experienced before until I met my much better half
[2:13:14] prevented me from resentment resentment is the barrier that will keep you from reparation
[2:13:22] and a future of I think equanimity because when you resent someone it means that you haven't
[2:13:28] processed you haven't moved forward and resentment usually comes by way of I think a poor choice
[2:13:34] of things such as did I win the argument did you win the argument it's not about point scoring
[2:13:40] at least and I've done that before I've been guilty of all of that behavior but now with this
[2:13:46] person that I cherish most you know I think of his lessons and it's not that we don't have conflict
[2:13:52] we do it's just that I value the person far beyond the conflict afterwards and I always want to reach
[2:14:00] out with an olive branch because it's not worth it just as you said when that call comes
[2:14:06] you know I I think of that sometimes when I have a bad day let's say someone you know I come back
[2:14:11] to my car and my car has been rear-ended when it's been parked or you know I was coming here
[2:14:18] to fly out and we were four hours on the tarmac waiting and there's a guy in front of me who's
[2:14:25] getting all agitated and giving the the ground staff all sorts of vitriol and I was thinking look
[2:14:32] when you're on your deathbed my good fellow are you going to look back at this day and think gosh
[2:14:39] you know I remember that one day when I was on that flight coming out to LA and it was four
[2:14:44] hours delayed no of course you're not so if you're not stressing about it when you're dying
[2:14:50] why are you stressing about it now it's just not worth it live thank you thank you so much I mean
[2:14:58] I can't thank you enough for the profound impact you've had on so many millions of people
[2:15:04] being the the chief torch bearer of the subjective sleep and creating a movement around sleep
[2:15:10] but also heightened awareness of ourselves and our struggles and that is something that you'll
[2:15:14] never understand like you'll never understand the full magnitude of the many millions of people
[2:15:18] you've positively impacted but I mean even though you'll never get to meet them all and you'll
[2:15:23] never get to hear all of our thank yous they are very very real people and they are they
[2:15:29] them themselves are these little ripples through the ocean where their children and then the
[2:15:33] generations to come get to sleep better and enjoy their lives and live a happier healthier life
[2:15:37] because of the work that you do so it's some incredibly important work Matthew and I hope
[2:15:42] you long continue it and along long continue being the conduit of this very important information
[2:15:46] to people like me and my audience can appreciate you more thank you so much for saying that I
[2:15:51] can't lay claim to any such affirmations but I would say that I stand on the shoulders of giants
[2:15:58] and that I am simply relaining all of the incredible work of all of my colleagues in the field and
[2:16:04] all of those who came before me I'm just the mouthpiece and not a particularly good one at that
[2:16:08] and for all of their work it's really the appreciation that I give to them so thank you for
[2:16:13] giving me the opportunity to say that make sure you keep one about to say to yourself I'm inviting
[2:16:22] 10,000 of you to come even deeper into the direvacio welcome to my inner circle this is a brand new
[2:16:29] private community that I'm launching to the world we have so many incredible things that happen
[2:16:33] that you are never shown we have the briefs that are on my pad when I'm recording the conversation
[2:16:38] we have clips we've never released we have behind the scenes conversations with the guests and also
[2:16:43] the episodes that we've never ever released and so much more in the circle you'll have direct access
[2:16:49] to me you can tell us what you want this show to be who you want us to interview and the types
[2:16:54] of conversations you would love us to have but remember for now we're only inviting the first 10,000
[2:17:00] people that joined before it closes so if you want to join our private close community head to
[2:17:04] the link in the description below or go to doccircle.com I will speak to you then
[2:17:19] you

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