# #523 Hotcakes: Left Atrial Appendage Closure vs AC for Afib, Apixaban vs Rivaroxaban for VTE, Intensive LDL Targeting, GLP1s and Substance Use Disorders, and more

An episode of [The Curbsiders Internal Medicine Podcast](https://invisiblenetwork.ai/podcast/1198732014), 27 Apr 2026, 1 h 02 min.

Audio: https://clrtpod.com/m/pscrb.fm/rss/p/dts.podtrac.com/redirect.mp3/audioboom.com/posts/8895816.mp3?modified=1781154530&sid=5034728&source=rss

Join us as we review recent practice-changing articles on left atrial appendage closure vs AC for AFib, apixaban vs rivaroxaban for VTE, intensive LDL targeting, GLP1s and substance use disorders, and more! Fill your brain hole with a delicious stack of hotcakes! Featuring Paul Williams (@PaulNWilliamz), Shani Herzig (@ShaniHerzig) Rahul Ganatra (@rbganatra), and Matt Watto (@doctorwatto). Claim CME for this episode at curbsiders.vcuhealth.org! Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CME Credits • Written and Hosted by: Rahul Ganatra MD, MPH; Shani Herzig, MD, MPH; Paul Williams, MD, FACP, Matthew Watto MD, FACP • Cover Art: Rahul Ganatra MD, MPH • Reviewer: Emi Okamoto, MD • Technical Production: Pod Paste • Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Show Segments • Intro, disclaimer • Left atrial appendage closure vs anticoagulation in AF • Apixaban vs rivaroxaban for VTE • Intensive LDL targeting in ASCVD • GLP1s and substance use disorders • FDA approves Orforglipron • E-cigarettes and cancer • Early AM blood draws and sleep quality • Outro Sponsor: FIGS Go to wearfigs.com to get 20% off during Nurses Week Sponsor: Panacea Financial If you're about to make the leap into residency and feeling the financial pressure of that transition, visit PanaceaFinancial.com/curbsiders today Sponsor: MasterClass Right now, as a listener of this show, you get at least 15% off any annual membership at MASTERCLASS.com/CURB.

Shows are listed from Apple Podcasts' charts and directory, and Podcast Index where it is used. Every show and episode belongs to its publisher and plays from the publisher's own feed; this site hosts none of them.