# Conférence - Arnold Kriegstein: Developing a Cell-Based Therapy for Medically-Intractable Epilepsy

An episode of [Paléoanthropologie du genre Homo - Jean-Jacques Hublin](https://invisiblenetwork.ai/podcast/1075753991), 14 Oct 2026, 35 min.

Audio: https://podcastfichiers.college-de-france.fr/hublin-conf-20261014-kriegstein.m4a

Jean-Jacques Hublin Chaire Paléoanthropologie Collège de France Année 2026-2027 Insights into the Development, Evolution, and Diseases of the Human Neocortex Conférence - Arnold Kriegstein: Developing a Cell-Based Therapy for Medically-Intractable Epilepsy Arnold Kriegstein Professeur de neurologie, université de Californie, San Francisco Résumé We have constructed a single-cell multiomic atlas of the human neocortex across development, revealing molecular and cellular dynamics in cell composition, spatial organization, intercellular signaling, gene regulation, and lineage potential. The atlas identifies novel progenitor lineages and offers a transcription-factor coded roadmap for deriving specific neural cell types from pluripotent stem cells. These developmental insights have enabled the generation of inhibitory interneurons from pluripotent stem cells that are now being tested in patients with medically resistant temporal lobe epilepsy. Encouraging clinical results have prompted plans for a pivotal trial that could ultimately establish a novel cell-based therapy for epilepsy.

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