# One and Two Dimensional NMR Spectroscopy for Chemists

- Institution: IISc Bangalore
- Department: Chemistry and Biochemistry
- Teacher: Prof. N. Suryaprakash
- Level: Graduate
- Language: English
- Subjects: Chemistry
- Source: [NPTEL](https://nptel.ac.in/courses/104108124)
- Licence: [CC BY-NC-SA](https://nptel.ac.in/faq) (Non-commercial use only.)
- Syllabus: [at the source](https://nptel.ac.in/courses/104108124)
- Who can watch: Tweens profiles and older (sources give no ratings; placed by Invisible Network from the source's own words)

In this course, I will discuss fundamental concepts of NMR spectroscopy, experimental determination of NMR spectral parameters, their interpretation, selective and broadband homo and Heteronuclear spin decoupling, numerous examples of the analysis of NMR spectra of 1H, 13C and other heteronuclei will be given. The relaxation processes, their measurement and utility in understanding molecular dynamics, the polarization transfer mechanism, the spectral editing techniques, such as, APT, DEPT, INEPT will also be discussed. Two dimensional NMR and the commonly employed experiments, viz., COSY, TOCSY, HSQC, HMQC, HMBC, NOESY, etc will be discussed with number of examples. The practical aspects of one and two dimensional NMR data acquisition and processing will also be highlighted. The solid state NMR, magic angle spinning and cross polarization will also be discussed.

Intended audience: It is for chemistry students, pharmaceutical students, biology students

## Lectures

1. [NMR an historical perspective and NMR active nuclei](https://invisiblenetwork.ai/learn/nptel/104108124/5afcdb591cec) (YouTube)
2. [Spin Angular Momentum and Magnetic moment](https://invisiblenetwork.ai/learn/nptel/104108124/dde464eb2717) (YouTube)
3. [Interaction of Spins with the magnetic field](https://invisiblenetwork.ai/learn/nptel/104108124/3027b0ee55c5) (YouTube)
4. [Larmor Precession and Energy of interaction](https://invisiblenetwork.ai/learn/nptel/104108124/4cf265f7c1fe) (YouTube)
5. [NMR detection and sensitivity](https://invisiblenetwork.ai/learn/nptel/104108124/f0f79b28ba7c) (YouTube)
6. [Inducing Resonance and Bulk Magnetization](https://invisiblenetwork.ai/learn/nptel/104108124/f8ac4f0461c7) (YouTube)
7. [Signal detection and Rotating Frame Concept](https://invisiblenetwork.ai/learn/nptel/104108124/aa76a71caaba) (YouTube)
8. [Pulse phase and signal phase](https://invisiblenetwork.ai/learn/nptel/104108124/23cc01ec665e) (YouTube)
9. [FID and Fourier Transformation](https://invisiblenetwork.ai/learn/nptel/104108124/65b2a0d4adcd) (YouTube)
10. [Selection rules and transitions](https://invisiblenetwork.ai/learn/nptel/104108124/579f82785d43) (YouTube)
11. [External and Internal interactions in NMR](https://invisiblenetwork.ai/learn/nptel/104108124/6ed031dddc82) (YouTube)
12. [Chemical Shifts](https://invisiblenetwork.ai/learn/nptel/104108124/64d2e7068b3b) (YouTube)
13. [NMR Spectrum and chemical equivalence](https://invisiblenetwork.ai/learn/nptel/104108124/a5eec7f01d30) (YouTube)
14. [Conversion of frequency and ppm](https://invisiblenetwork.ai/learn/nptel/104108124/e16958b04aca) (YouTube)
15. [Field dependence and factors affecting chemical shift](https://invisiblenetwork.ai/learn/nptel/104108124/21a389459c01) (YouTube)
16. [Factors contributing to chemical shifts](https://invisiblenetwork.ai/learn/nptel/104108124/67cccd1cd969) (YouTube)
17. [Factors contributing to chemical shifts -2](https://invisiblenetwork.ai/learn/nptel/104108124/55632c001e08) (YouTube)
18. [Scalar Couplings](https://invisiblenetwork.ai/learn/nptel/104108124/f32898434a1c) (YouTube)
19. [Scalar Couplings -2](https://invisiblenetwork.ai/learn/nptel/104108124/c561a4227ce3) (YouTube)
20. [Energy levels of coupled spins](https://invisiblenetwork.ai/learn/nptel/104108124/8adc2a9d02f2) (YouTube)
21. [Spin system classification and multiplicity](https://invisiblenetwork.ai/learn/nptel/104108124/788e2b70ad43) (YouTube)
22. [Multiplicity pattern of coupled spins](https://invisiblenetwork.ai/learn/nptel/104108124/82676e110280) (YouTube)
23. [Active and passive coupling](https://invisiblenetwork.ai/learn/nptel/104108124/14db25763e1b) (YouTube)
24. [Coupling among equivalent spins](https://invisiblenetwork.ai/learn/nptel/104108124/4e507b7862a4) (YouTube)
25. [Coupling among equivalent spins – 2](https://invisiblenetwork.ai/learn/nptel/104108124/c910ed2f9f4d) (YouTube)
26. [Coupling among non-equivalent spins](https://invisiblenetwork.ai/learn/nptel/104108124/337d464aa22f) (YouTube)
27. [Geminal and Vicinal couplings](https://invisiblenetwork.ai/learn/nptel/104108124/cee93232449f) (YouTube)
28. [Spin system Nomenclature](https://invisiblenetwork.ai/learn/nptel/104108124/a76a2b9541fb) (YouTube)
29. [Isotope effect](https://invisiblenetwork.ai/learn/nptel/104108124/6ed55e7364ea) (YouTube)
30. [Analysis of Strongly coupled spin systems](https://invisiblenetwork.ai/learn/nptel/104108124/2f1113a72f00) (YouTube)
31. [Eigen values of A2 and AMX spin systems](https://invisiblenetwork.ai/learn/nptel/104108124/c75a3e871c04) (YouTube)
32. [Analysis of Three spin coupled systems](https://invisiblenetwork.ai/learn/nptel/104108124/e7d9d4b16498) (YouTube)
33. [Analysis of Proton NMR spectra](https://invisiblenetwork.ai/learn/nptel/104108124/b1245aa7fce8) (YouTube)
34. [Analysis of Proton NMR spectra – 2](https://invisiblenetwork.ai/learn/nptel/104108124/c917b9f9f5c9) (YouTube)
35. [Analysis of Proton NMR spectra – 3](https://invisiblenetwork.ai/learn/nptel/104108124/b9b9b5fb7621) (YouTube)
36. [Basics of 13C-NMR](https://invisiblenetwork.ai/learn/nptel/104108124/cd2e8a8ea108) (YouTube)
37. [Coupled and Decoupled 13C-Spectra](https://invisiblenetwork.ai/learn/nptel/104108124/5038d83b89bb) (YouTube)
38. [Broadband decoupling in 13C-NMR](https://invisiblenetwork.ai/learn/nptel/104108124/f794bb215b40) (YouTube)
39. [Analysis of 13C spectra and DEPT](https://invisiblenetwork.ai/learn/nptel/104108124/daee40601d43) (YouTube)
40. [Heteronuclear couplings and satellite analysis](https://invisiblenetwork.ai/learn/nptel/104108124/104cef758c1c) (YouTube)
41. [Heteronuclear couplings and satellite analysis -2](https://invisiblenetwork.ai/learn/nptel/104108124/24e24b036496) (YouTube)
42. [Coupling among magnetic equivalent nuclei and isotope effect](https://invisiblenetwork.ai/learn/nptel/104108124/acfa223917f5) (YouTube)
43. [Analysis of spectra of other nuclei](https://invisiblenetwork.ai/learn/nptel/104108124/0e4c5f314d23) (YouTube)
44. [Spin Echoes](https://invisiblenetwork.ai/learn/nptel/104108124/957f7dadc0e9) (YouTube)
45. [Polarization transfer techniques](https://invisiblenetwork.ai/learn/nptel/104108124/5f02d1afdb23) (YouTube)
46. [INEPT and DEPT](https://invisiblenetwork.ai/learn/nptel/104108124/412354abbf01) (YouTube)
47. [Decoupling and NOE](https://invisiblenetwork.ai/learn/nptel/104108124/2734ee248a07) (YouTube)
48. [NOE-2](https://invisiblenetwork.ai/learn/nptel/104108124/128114212af9) (YouTube)
49. [Introduction to 2D NMR](https://invisiblenetwork.ai/learn/nptel/104108124/845b265d2034) (YouTube)
50. [Two-dimensional NMR](https://invisiblenetwork.ai/learn/nptel/104108124/98b15753af51) (YouTube)
51. [Two dimensional NMR](https://invisiblenetwork.ai/learn/nptel/104108124/0ba3d46a95eb) (YouTube)
52. [Two dimensional COSY](https://invisiblenetwork.ai/learn/nptel/104108124/c5b58879161e) (YouTube)
53. [COSY and examples](https://invisiblenetwork.ai/learn/nptel/104108124/759e43ceb878) (YouTube)
54. [Variants of COSY and TOCSY spectra](https://invisiblenetwork.ai/learn/nptel/104108124/1b63991b7bf8) (YouTube)
55. [Heteronuclear correlation and inverse detection](https://invisiblenetwork.ai/learn/nptel/104108124/8c0781d34ab3) (YouTube)
56. [Coupled and decoupled HSQC and HMBC](https://invisiblenetwork.ai/learn/nptel/104108124/59ae4adefa59) (YouTube)
57. [NMR data acquisition](https://invisiblenetwork.ai/learn/nptel/104108124/26ee5cdecc4f) (YouTube)
58. [NMR data acquisition - 2](https://invisiblenetwork.ai/learn/nptel/104108124/b6130174fe28) (YouTube)
59. [Practical considerations of 1D NMR](https://invisiblenetwork.ai/learn/nptel/104108124/06082e5a603c) (YouTube)
60. [NMR Data processing](https://invisiblenetwork.ai/learn/nptel/104108124/d737522f68e1) (YouTube)
61. [NMR data processing](https://invisiblenetwork.ai/learn/nptel/104108124/c5b5ea98c114) (YouTube)
62. [NMR Instrumentation](https://invisiblenetwork.ai/learn/nptel/104108124/7a11c58ef2e3) (YouTube)
63. [NMR Instrumentation – 2](https://invisiblenetwork.ai/learn/nptel/104108124/d8b27e66a378) (YouTube)
64. [Relaxation processes](https://invisiblenetwork.ai/learn/nptel/104108124/c93d36cc6240) (YouTube)
65. [Relaxation processes - 2](https://invisiblenetwork.ai/learn/nptel/104108124/25bb0458fc5f) (YouTube)