# Essentials of Oxidation, Reduction and C-C Bond Formation. Application in Organic Synthesis

- Institution: IIT Bombay
- Department: Chemistry and Biochemistry
- Teacher: Prof. Yashwant D Vankar
- Level: Undergraduate
- Language: English
- Subjects: Chemistry
- Source: [NPTEL](https://nptel.ac.in/courses/104101127)
- Licence: [CC BY-NC-SA](https://nptel.ac.in/faq) (Non-commercial use only.)
- Syllabus: [at the source](https://nptel.ac.in/courses/104101127)
- Who can watch: Teens profiles and older (sources give no ratings; placed by Invisible Network from the source's own words)

## Lectures

1. [Lecture 1 : Introduction to organic synthesis-Importance of selectivity, stereochemistry and Mechanism](https://invisiblenetwork.ai/learn/nptel/104101127/843b709c7e55) (Video)
2. [Lecture 2 : Sulfur based oxidations of alcohols](https://invisiblenetwork.ai/learn/nptel/104101127/0af10edf41f6) (Video)
3. [Lecture 3 : Sulfur based oxidations and Pummerer rearrangement](https://invisiblenetwork.ai/learn/nptel/104101127/2f81cc4cd35c) (Video)
4. [Lecture 4 : Further aspects of sulfur and selenium based oxidations](https://invisiblenetwork.ai/learn/nptel/104101127/42572dadd5a0) (Video)
5. [Lecture 5 : Organoselenium chemistry and SeO2 based oxidations](https://invisiblenetwork.ai/learn/nptel/104101127/f2e5dee7d9b4) (Video)
6. [Lecture 6 : SeO2 based oxidation of ketones and Sulfoxide- Sulfenate rearrangement (Mislow-Evans rearrangement)](https://invisiblenetwork.ai/learn/nptel/104101127/a2b1b5e75d13) (Video)
7. [Lecture 7 : Mechanistic and stereochemical aspects of Mislow-Evans rearrangement and synthetic applications](https://invisiblenetwork.ai/learn/nptel/104101127/d47652c3c644) (Video)
8. [Lecture 8 : Further synthetic applications of Mislow-Evans rearrangement and Saegusa-Ito oxidation](https://invisiblenetwork.ai/learn/nptel/104101127/91f452bf4da3) (Video)
9. [Lecture 9 : 1,2-Ketone transpositions, Shapiro reaction and Dauben-Michno rearrangement (a case of 1,3-enone transposition)](https://invisiblenetwork.ai/learn/nptel/104101127/b292d7a73163) (Video)
10. [Lecture 10 : Dess-Martin periodinane oxidation](https://invisiblenetwork.ai/learn/nptel/104101127/f6ee78623476) (Video)
11. [Lecture 11 : Iodoxybenzoic acid (IBX) based oxidations](https://invisiblenetwork.ai/learn/nptel/104101127/7800ae16432a) (Video)
12. [Lecture 12 : Silver based oxidations: Prevost reaction and use of Fetizon's reagent](https://invisiblenetwork.ai/learn/nptel/104101127/d1ed78f6fe08) (Video)
13. [Lecture 13 : Further aspects of oxidations using Fetizon's reagent: Mechanism and Stereochemistry](https://invisiblenetwork.ai/learn/nptel/104101127/1d363b699697) (Video)
14. [Lecture 14 : Ruthenium tetroxide (and RuCl3/NaIO4) mediated oxidations](https://invisiblenetwork.ai/learn/nptel/104101127/17bc6104429f) (Video)
15. [Lecture 15 : Tetra-n-propylammonium perruthenate (TPAP) based oxidations, and Tamao-Fleming oxidation](https://invisiblenetwork.ai/learn/nptel/104101127/988f83552190) (Video)
16. [Lecture 16 : Further synthetic and mechanistic aspects of Tamao-Fleming oxidations](https://invisiblenetwork.ai/learn/nptel/104101127/e7a605185fc4) (Video)
17. [Lecture 17 : Oxidations with dimethyl dioxirane (DMDO)](https://invisiblenetwork.ai/learn/nptel/104101127/6f8dc9d9f416) (Video)
18. [Lecture 18 : Mechanistic aspects of DMDO based oxidations and oxaziridine mediated alpha-hydroxylations of ketones](https://invisiblenetwork.ai/learn/nptel/104101127/235973c3744d) (Video)
19. [Lecture 19 : Asymmetric alpha-hydroxylations using oxaziridine based reactions](https://invisiblenetwork.ai/learn/nptel/104101127/d0a5634c2f55) (Video)
20. [Lecture 20 : Barton and related reactions (oxidation at unfunctionalised carbons) and synthetic applications](https://invisiblenetwork.ai/learn/nptel/104101127/a62feb64c60f) (Video)
21. [Lecture 21 : beta-Cleavage in Barton and related reactions and miscellaneous oxidations such as TEMPO based oxidations, Pinnick oxidation and pseudomonas putida mediated oxidations](https://invisiblenetwork.ai/learn/nptel/104101127/ee77b0ad8d0b) (Video)
22. [Lecture 22 : Reductions in organic chemistry: Metal hydride (NaBH4 & LiAlH4) mediated reduction](https://invisiblenetwork.ai/learn/nptel/104101127/f090db1eb5b0) (Video)
23. [Lecture 23 : Reductions using diisobutylaluminum hydride (DIBAL-H)](https://invisiblenetwork.ai/learn/nptel/104101127/7d6a372e349d) (Video)
24. [Lecture 24 : Further aspects of DIBAL-H based reductions and comparison with mixed chloride hydrides](https://invisiblenetwork.ai/learn/nptel/104101127/8fcfbda757bb) (Video)
25. [Lecture 25 : Reductions with Red-Al, and Luche Reductions](https://invisiblenetwork.ai/learn/nptel/104101127/3f5fdef1f384) (Video)
26. [Lecture 26 : Further aspects of Luche reduction, stereochemistry in reductions & reduction with LiBH4](https://invisiblenetwork.ai/learn/nptel/104101127/cca15d77a5fc) (Video)
27. [Lecture 27 : Reductions with Zn(BH4)2, LiBHEt3 (superhydride) & L & K-selectrides](https://invisiblenetwork.ai/learn/nptel/104101127/58c42f2a3f66) (Video)
28. [Lecture 28 : Reductions with LS/KS selectrides and NaCNBH3](https://invisiblenetwork.ai/learn/nptel/104101127/f3c07c57f238) (Video)
29. [Lecture 29 : Dissolving metal reductions (Na, K, Mg) & McMurry coupling using Ti(0)](https://invisiblenetwork.ai/learn/nptel/104101127/1615538d38e2) (Video)
30. [Lecture 30 : Stereochemistry and mechanistic aspects of McMurry coupling & metal mediated reductions of alpha, beta-unsaturated ketones](https://invisiblenetwork.ai/learn/nptel/104101127/e2236c1ef3a5) (Video)
31. [Lecture 31 : Silanes \[R3SiH, including polymethylhydrosiloxanes (PMHS)\] as reducing agents](https://invisiblenetwork.ai/learn/nptel/104101127/3d2708a28b30) (Video)
32. [Lecture 32 : Further aspects of silanes as reducing agents & Barton-McCombie deoxygenation](https://invisiblenetwork.ai/learn/nptel/104101127/12ef446d04fb) (Video)
33. [Lecture 33 : Tributyltinhydride (n-Bu3SnH) based radical based reductions & C-C bond formations](https://invisiblenetwork.ai/learn/nptel/104101127/3a8c01b2864d) (Video)
34. [Lecture 34 : Asymmetric synthesis: An introduction](https://invisiblenetwork.ai/learn/nptel/104101127/8103559de614) (Video)
35. [Lecture 35 : Sharpless asymmetric epoxidation: Mechanism, stereochemistry and kinetic resolution](https://invisiblenetwork.ai/learn/nptel/104101127/0b2ed7cdbc8a) (Video)
36. [Lecture 36 : Synthetic utility of chiral 2,3-epoxy alcohols obtained from Sharpless epoxidation](https://invisiblenetwork.ai/learn/nptel/104101127/5eab9ef91493) (Video)
37. [Lecture 37 : Katsuki-Jacobsen epoxidation: Mechanism and stereochemistry](https://invisiblenetwork.ai/learn/nptel/104101127/5eb6a0ee0dfc) (Video)
38. [Lecture 38 : Further aspects of Katsuki-Jacobsen epoxidation, & Introduction to Sharpless Asymmetric Dihydroxylation](https://invisiblenetwork.ai/learn/nptel/104101127/be358bfdcc6d) (Video)
39. [Lecture 39 : Mechanism, stereochemical aspects and synthetic applications of Sharpless Asymmetric Dihydroxylation](https://invisiblenetwork.ai/learn/nptel/104101127/f73486c0dccb) (Video)
40. [Lecture 40 : Asymmetric hydrogenations and reductions using rhodium and ruthenium derived chiral catalysts](https://invisiblenetwork.ai/learn/nptel/104101127/297eeb7782f8) (Video)
41. [Lecture 41 : Asymmetric reduction with oxazaborilidines](https://invisiblenetwork.ai/learn/nptel/104101127/d8d108fa7f62) (Video)
42. [Lecture 42 : C-C bond formations: Introduction to enolate, enamine and enol silyl ether based chemistry](https://invisiblenetwork.ai/learn/nptel/104101127/0af498d1bc2c) (Video)
43. [Lecture 43 : C-C bond formations using enol silyl ether and imine based chemistry including SAMP and RAMP based asymmetric alkylations](https://invisiblenetwork.ai/learn/nptel/104101127/c661515caed4) (Video)
44. [Lecture 44 : Asymmetric C-C bond formations using Oppolzer's camphorsultams and introduction to directed Aldol reactions](https://invisiblenetwork.ai/learn/nptel/104101127/3fa0fbe3a045) (Video)
45. [Lecture 45 : Further aspects of Aldol chemistry including the use of boron and silicon enolates](https://invisiblenetwork.ai/learn/nptel/104101127/1dea67829fa0) (Video)
46. [Lecture 46 : C-C bond formations using Evans' oxazolidinone based chemistry](https://invisiblenetwork.ai/learn/nptel/104101127/a457e11c5e7f) (Video)
47. [Lecture 47 : Ireland-Claisen rearrangement: Emphasis of enolate geometry on the stereochemical outcome, and Claisen rearrangements](https://invisiblenetwork.ai/learn/nptel/104101127/7ec115de8c72) (Video)
48. [Lecture 48 : Aromatic Claisen rearrangement, Johnson-Claisen rearrangement and Eschenmoser-Claisen rearrangement and synthetic](https://invisiblenetwork.ai/learn/nptel/104101127/d8061d261071) (Video)
49. [Lecture 49 : Bellus-Claisen rearrangement, Aza-Claisen rearrangement, Thia-Claisen rearrangement, Chen-Mapp rearrangement and their synthetic applications](https://invisiblenetwork.ai/learn/nptel/104101127/ef871233892e) (Video)
50. [Lecture 50 : Zwitterionic-Claisen rearrangement, Overmann rearrangement, Bamford- Stevens and Shapiro reactions and synthetic applications](https://invisiblenetwork.ai/learn/nptel/104101127/5bba8da690b9) (Video)
51. [Lecture 51 : Introduction to allyl metal additions for C-C bond formation](https://invisiblenetwork.ai/learn/nptel/104101127/c6a7f525aa64) (Video)
52. [Lecture 52 : Allylindium chemistry: Mechanism, stereochemistry and synthetic applications](https://invisiblenetwork.ai/learn/nptel/104101127/30e53c4d89b1) (Video)
53. [Lecture 53 : Allyltin chemistry: Mechanism, stereochemistry and synthetic applications](https://invisiblenetwork.ai/learn/nptel/104101127/41b40b9a6487) (Video)
54. [Lecture 54 : Chemistry of allylsilanes: Mechanism, stereochemistry and synthetic applications (Part 1)](https://invisiblenetwork.ai/learn/nptel/104101127/cf033a75b77b) (Video)
55. [Lecture 55 : Further synthetic aspects of the chemistry of allylsilanes (Part 2)](https://invisiblenetwork.ai/learn/nptel/104101127/51a1d82d74d5) (Video)
56. [Lecture 56 : Further synthetic aspects of the chemistry of allylsilanes (Part 3)](https://invisiblenetwork.ai/learn/nptel/104101127/86a1555089bb) (Video)
57. [Lecture 57 : Chemistry of vinylsilanes: Mechanism, stereochemistry and synthetic applications](https://invisiblenetwork.ai/learn/nptel/104101127/e4d8997b2df6) (Video)
58. [Lecture 58 : Peterson olefination and further synthetic aspects of vinylsilane chemistry](https://invisiblenetwork.ai/learn/nptel/104101127/ab77c6ecd064) (Video)
59. [Lecture 59 : Simmons-Smith cyclopropanation: Mechanism, stereochemistry and synthetic applications](https://invisiblenetwork.ai/learn/nptel/104101127/8cc6548e362a) (Video)
60. [Lecture 60 : Course Summary and conclusion](https://invisiblenetwork.ai/learn/nptel/104101127/524c19b6071b) (Video)
61. [Live Session 15-02-2022](https://invisiblenetwork.ai/learn/nptel/104101127/843b709c7e55-2) (Video)
62. [Live Session 04-05-2022](https://invisiblenetwork.ai/learn/nptel/104101127/0af10edf41f6-2) (Video)
63. [Live Session 27-02-2024](https://invisiblenetwork.ai/learn/nptel/104101127/2f81cc4cd35c-2) (Video)
64. [Live Session 24-02-2025](https://invisiblenetwork.ai/learn/nptel/104101127/42572dadd5a0-2) (Video)