# Pharmacological and Toxicological Screening Methods

- Institution: IIT (BHU) Varanasi
- Department: Chemical Engineering
- Teacher: Prof. Vinod Tiwari
- Level: Undergraduate
- Language: English
- Subjects: Chemistry, Engineering
- Source: [NPTEL](https://nptel.ac.in/courses/103106785)
- Licence: [CC BY-NC-SA](https://nptel.ac.in/faq) (Non-commercial use only.)
- Syllabus: [at the source](https://nptel.ac.in/courses/103106785)
- Who can watch: Teens profiles and older (sources give no ratings; placed by Invisible Network from the source's own words)

This 12-week course, Pharmacological and Toxicological Screening Methods, offers a comprehensive exploration of the methodologies and tools vital for assessing the therapeutic potential and safety profiles of new drugs, chemicals, and biological compounds. The program begins with foundational principles of Pharmacological assays, emphasizing toxicity types, dose-response relationships, and safety thresholds. As the course progresses, participants delve into advanced screening techniques, including in vitro assays (e.g., cell-based models, enzyme inhibition studies) and in vivo methods (e.g., animal models for efficacy and toxicity). Additionally, the curriculum incorporates OECD guidelines, ethical considerations in animal research, and alternatives to animal experimentation, providing a well-rounded understanding of preclinical evaluation techniques.

Intended audience: Pharmacy professionals, Pharmacologists, Biologists, Biotechnologists

Prerequisites: The participants should have basic knowledge of biology. A keen interest in the domains of biochemistry, physiology, and molecular biology is desirable.

## Lectures

1. [Morals of Animal Testing & 3R Strategy](https://invisiblenetwork.ai/learn/nptel/103106785/eb16f190a7eb) (YouTube)
2. [Common Laboratory Animals & Maintenance Part - A](https://invisiblenetwork.ai/learn/nptel/103106785/4d1afdeca9e7) (YouTube)
3. [Common Laboratory Animals & Maintenance Part - B](https://invisiblenetwork.ai/learn/nptel/103106785/28da5602279d) (YouTube)
4. [CCSEA Guidelines for Experimentation on Animals Part - 1](https://invisiblenetwork.ai/learn/nptel/103106785/dd4a37bcbf03) (YouTube)
5. [CCSEA Gidelines for Experimentation on Animals - Part 2](https://invisiblenetwork.ai/learn/nptel/103106785/a03f25ba1e9d) (YouTube)
6. [Form B per rule 8a for Submission of Research protocols](https://invisiblenetwork.ai/learn/nptel/103106785/25a0abed263a) (YouTube)
7. [Anesthesia and Euthanasia of Experimental Animals](https://invisiblenetwork.ai/learn/nptel/103106785/61a888761715) (YouTube)
8. [Alternatives to Animals Usage in Research](https://invisiblenetwork.ai/learn/nptel/103106785/c7fa74af4d20) (YouTube)
9. [In vitro Models](https://invisiblenetwork.ai/learn/nptel/103106785/708dd58db736) (YouTube)
10. [Stem Cell Therapy, Skin Patch Test](https://invisiblenetwork.ai/learn/nptel/103106785/4d6a989a48f9) (YouTube)
11. [In silico Models, Microfluidic Chips & Recent Trends](https://invisiblenetwork.ai/learn/nptel/103106785/0bf2a3e70049) (YouTube)
12. [High Throughput Screening HTS Assays](https://invisiblenetwork.ai/learn/nptel/103106785/921cddd76eb8) (YouTube)
13. [Western Blotting](https://invisiblenetwork.ai/learn/nptel/103106785/e2357f410fc1) (YouTube)
14. [Assay and its Types - Part A](https://invisiblenetwork.ai/learn/nptel/103106785/ae428edeb838) (YouTube)
15. [Assay & its Types - Part B](https://invisiblenetwork.ai/learn/nptel/103106785/50ffaacf40f1) (YouTube)
16. [Introduction to Alzheimer's Disease](https://invisiblenetwork.ai/learn/nptel/103106785/cd73bab5857c) (YouTube)
17. [Symptoms & Pathophysiology of Alzheimer's Disease](https://invisiblenetwork.ai/learn/nptel/103106785/30aec07153e3) (YouTube)
18. [Screening Models of Alzheimer's Disease](https://invisiblenetwork.ai/learn/nptel/103106785/c55fd9fc7510) (YouTube)
19. [Introduction to Parkinson's Desease](https://invisiblenetwork.ai/learn/nptel/103106785/3e5aff028360) (YouTube)
20. [Models of Parkinson,s Disease](https://invisiblenetwork.ai/learn/nptel/103106785/e97fd37c43c3) (YouTube)
21. [Introduction to Depression](https://invisiblenetwork.ai/learn/nptel/103106785/0628052dc589) (YouTube)
22. [Diagnosis & Pharmacotherapeutics for the Treatment of Depression](https://invisiblenetwork.ai/learn/nptel/103106785/44074090b123) (YouTube)
23. [Models for the Screening of Anti depressant Drugs](https://invisiblenetwork.ai/learn/nptel/103106785/600b060bf26e) (YouTube)
24. [Behavioural Tests for the Assessment of Anti depressant Activity](https://invisiblenetwork.ai/learn/nptel/103106785/98dd9f7feff7) (YouTube)
25. [Introduction to Pain and Its Pathobiology](https://invisiblenetwork.ai/learn/nptel/103106785/b5da7b7821c6) (YouTube)
26. [Preclinical Models for Neuropathic Pain](https://invisiblenetwork.ai/learn/nptel/103106785/937e846f0f5c) (YouTube)
27. [Preclinical Models for Inflammatory Pain](https://invisiblenetwork.ai/learn/nptel/103106785/a6c14649ab8e) (YouTube)
28. [Behavioural Assays for Pain Measurement in Animals](https://invisiblenetwork.ai/learn/nptel/103106785/a843b70a5554) (YouTube)
29. [Behavioural Assays for Spontaneous Pain Assessment](https://invisiblenetwork.ai/learn/nptel/103106785/d0f226b187ce) (YouTube)
30. [Introduction to Diabetes](https://invisiblenetwork.ai/learn/nptel/103106785/eb84553dfa1a) (YouTube)
31. [Pathophysiology & Diagnosis of Diabetes](https://invisiblenetwork.ai/learn/nptel/103106785/fa80ae34f295) (YouTube)
32. [Current Pharmacotherapeutics Used for the Treatment of Diabetes Mellitus](https://invisiblenetwork.ai/learn/nptel/103106785/2e258d227c87) (YouTube)
33. [In Vitro Models of Diabetes Mellitus](https://invisiblenetwork.ai/learn/nptel/103106785/9f70f8c27862) (YouTube)
34. [In Vitro Models of Diabetes Mellitus](https://invisiblenetwork.ai/learn/nptel/103106785/003993e311d8) (YouTube)
35. [Pharmacological Screening & Its Types](https://invisiblenetwork.ai/learn/nptel/103106785/fe26fb97c4a6) (YouTube)
36. [Transgenic Animals Production & Maintenance](https://invisiblenetwork.ai/learn/nptel/103106785/8491066e1f71) (YouTube)
37. [Humanized Mouse Introduction](https://invisiblenetwork.ai/learn/nptel/103106785/57a68fbee602) (YouTube)
38. [Application of Transgenic Animals](https://invisiblenetwork.ai/learn/nptel/103106785/7718a8878e83) (YouTube)
39. [Applications of Humanized Mouse Model](https://invisiblenetwork.ai/learn/nptel/103106785/a31171200483) (YouTube)
40. [Introduction to Toxicology](https://invisiblenetwork.ai/learn/nptel/103106785/6aef02d2bb5f) (YouTube)
41. [Mechanisms of Toxicity & Toxicant Action](https://invisiblenetwork.ai/learn/nptel/103106785/a64dd1c421d5) (YouTube)
42. [Toxicity Testing Studies as per OECD Guidelines](https://invisiblenetwork.ai/learn/nptel/103106785/86650f0f5a4a) (YouTube)
43. [ICH Guidelines for Drug Toxicity Studies](https://invisiblenetwork.ai/learn/nptel/103106785/8a2b41f23b0d) (YouTube)
44. [Good Laboratry Practices for Safety Studies](https://invisiblenetwork.ai/learn/nptel/103106785/f7411b1fcd45) (YouTube)
45. [Acute & Sb Acute Toxicity Studies](https://invisiblenetwork.ai/learn/nptel/103106785/3827930d366e) (YouTube)
46. [Chronic Toxicity Studies](https://invisiblenetwork.ai/learn/nptel/103106785/9ad2b69d8d8b) (YouTube)
47. [Mutagenicity & Genotoxicity Studies](https://invisiblenetwork.ai/learn/nptel/103106785/e773b112d34a) (YouTube)
48. [Teratogenicity Studies](https://invisiblenetwork.ai/learn/nptel/103106785/d23d27626216) (YouTube)
49. [Reproductive Toxicology](https://invisiblenetwork.ai/learn/nptel/103106785/fd14ffd57edb) (YouTube)
50. [Neurobehavioral Toxicology](https://invisiblenetwork.ai/learn/nptel/103106785/9cedfe37dd49) (YouTube)
51. [Cardiovascular Toxicity](https://invisiblenetwork.ai/learn/nptel/103106785/af9c5b9c4213) (YouTube)
52. [Respiratory Toxicology](https://invisiblenetwork.ai/learn/nptel/103106785/af4a343f0acf) (YouTube)
53. [Dermal Toxicology](https://invisiblenetwork.ai/learn/nptel/103106785/cc8eff2e4d59) (YouTube)
54. [Toxicology of The Liver](https://invisiblenetwork.ai/learn/nptel/103106785/52d0f82cf53e) (YouTube)
55. [Introduction of Carcinogenesis](https://invisiblenetwork.ai/learn/nptel/103106785/e2acb70a049d) (YouTube)
56. [Categories of Carcinogenicity Studies](https://invisiblenetwork.ai/learn/nptel/103106785/02fe85a2a4e0) (YouTube)
57. [Autophagy & Apoptosis](https://invisiblenetwork.ai/learn/nptel/103106785/e81c1bf1c9a0) (YouTube)
58. [Apoptotic Pathways & Necroptosis](https://invisiblenetwork.ai/learn/nptel/103106785/7f396a96ee6b) (YouTube)
59. [Methods to Screen Carcinogens & Anti Cancer Agents](https://invisiblenetwork.ai/learn/nptel/103106785/a98f1280c556) (YouTube)