# Systems Biology

- Institution: Massachusetts Institute of Technology
- Department: Physics; Biology
- Teacher: Prof. Jeff Gore
- Term: Fall 2014
- Level: Undergraduate
- Language: English
- Subjects: Physics, Biology, Computer science, Engineering
- Source: [MIT OpenCourseWare](https://ocw.mit.edu/courses/8-591j-systems-biology-fall-2014/)
- Licence: [CC BY-NC-SA 4.0](https://creativecommons.org/licenses/by-nc-sa/4.0/) (Non-commercial use only.)
- Syllabus: [at the source](https://ocw.mit.edu/courses/8-591j-systems-biology-fall-2014/pages/syllabus/)
- Readings: [at the source](https://ocw.mit.edu/courses/8-591j-systems-biology-fall-2014/pages/readings/)
- Who can watch: Teens profiles and older (sources give no ratings; placed by Invisible Network from the source's own words)

This course provides an introduction to cellular and population-level systems biology with an emphasis on synthetic biology, modeling of genetic networks, cell-cell interactions, and evolutionary dynamics. Cellular systems include genetic switches and oscillators, network motifs, genetic network evolution, and cellular decision-making. Population-level systems include models of pattern formation, cell-cell communication, and evolutionary systems biology.

## Lectures

1. [Introduction to the Class and Overview of Topics](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/7b0af23bb19f), 1 h 8 min (Video)
2. [Input Function, Michaelis-Menten kinetics, and Cooperativity](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/a65e27706122), 1 h 18 min (Video)
3. [Autoregulation, Feedback and Bistability](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/771044dc125e), 1 h 19 min (Video)
4. [Synthetic Biology and Stability Analysis in the Toggle Switch](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/ae1a3c15f311), 1 h 20 min (Video)
5. [Oscillatory Genetic Networks](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/a251f2ec5a0b), 1 h 22 min (Video)
6. [Graph Properties of Transcription Networks](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/778b4985b2de), 1 h 22 min (Video)
7. [Feed-forward Loop Network Motif](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/e43a1ff5b2bd), 1 h 22 min (Video)
8. [Introduction to Stochastic Gene Expression](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/aaefe56054eb), 1 h 21 min (Video)
9. [Causes and Consequences of Stochastic Gene Expression](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/2e024c3ea377), 1 h 21 min (Video)
10. [Stochastic Modeling](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/941468a9aeed), 1 h 22 min (Video)
11. [Life at Low Reynolds Number](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/4996b4690b78), 1 h 20 min (Video)
12. [Robustness and Bacterial Chemotaxis](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/6369d28ee99b), 1 h 19 min (Video)
13. [Robustness in Development and Pattern Formation](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/d0de2784512a), 1 h 22 min (Video)
14. [Microbial Evolution Experiments and Optimal Gene Circuit Design](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/fc9f68e60426), 1 h 20 min (Video)
15. [Evolution in Finite Populations](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/4e26dde12b6b), 1 h 21 min (Video)
16. [Clonal Interference and the Distribution of Beneficial Mutations](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/a63eb1c19710), 1 h 22 min (Video)
17. [Fitness Landscapes and Sequence Spaces](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/a9fa83b463d9), 1 h 19 min (Video)
18. [Evolutionary Games](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/dd10534ebbd7), 1 h 21 min (Video)
19. [Survival in Fluctuating Environments](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/a1855e4b12c4), 1 h 19 min (Video)
20. [Parasites, the Evolution of Virulence and Sex](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/cc0f914a49fb), 1 h 19 min (Video)
21. [Interspecies Interactions](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/38fde05e07ca), 1 h 22 min (Video)
22. [Ecosystem Stability, Critical Transitions, and Biodiversity](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/48e065a6b38b), 1 h 21 min (Video)
23. [Dynamics of Populations in Space](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/6c6ac891e65e), 1 h 21 min (Video)
24. [The Neutral Theory of Ecology](https://invisiblenetwork.ai/learn/mit/8-591j-systems-biology-fall-2014/00d7b9e1955a), 1 h 18 min (Video)